DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18190 and MAPRE2

DIOPT Version :9

Sequence 1:	NP_611384.2	Gene:	CG18190 / 37179	FlyBaseID:	FBgn0034403	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	NP_055083.1	Gene:	MAPRE2 / 10982	HGNCID:	6891	Length:	327	Species:	Homo sapiens

Alignment Length:	290	Identity:	103/290 - (35%)
Similarity:	156/290 - (53%)	Gaps:	51/290 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKLTVALTSVNAENMSRHDMLQWVNNMVHGHFKKIEELCSGAAYCQMMEMIFPNCINLKRVKMTA 68
            :.:.|..||:..|.|||||::.|||::|..::.|:|:|||||||||.|:|:||.||:||:||..|
Human    44 MAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQA 108

  Fly    69 KLEHEYLHNLRLFQEAFNRLKLDKTVPIDRLIKGRFQDNFEFLQWFKKFFDSQAPGL-------- 125
            ||||||:||.:|.|.:|.|:.:||.:|:::|:|||||||.:|:||||||:|:...|.
Human   109 KLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEAR 173

  Fly   126 ------------ENIKSL------ANAPLAKPIKPRQFAKERS----PVNA-----------NDD 157
                        |.|.:|      ||:|.|...|....||..|    |.:|           :|.
Human   174 QGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPAAKPGSTPSRPSSAKRASSSGSASKSDK 238

  Fly   158 ALK----ELIDEMKNLSLKREDIMEASNQIYNKLRLVEDLVNDMINNNQLVELCKRIQAVLYKTI 218
            .|:    :|.:::.:|.|..|.:.:..:..:.|||.:|.|..:....|.  :|.:|:..:||.:.
Human   239 DLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQEND--DLVQRLMDILYASE 301

  Fly   219 DGEINEEPVEVNEDNGDEGAEHADPNDGLY 248
            :.|.:.|..|..|    :..|...|....|
Human   302 EHEGHTEEPEAEE----QAHEQQPPQQEEY 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18190	NP_611384.2	CH	19..>92	CDD:278723	42/72 (58%)
CG18190	NP_611384.2	EB1	184..216	CDD:281288	9/31 (29%)
MAPRE2	NP_055083.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		BIM1	59..313	CDD:227542	94/255 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..240		14/68 (21%)
		DCTN1-binding	187..327		34/145 (23%)
		APC-binding	259..302		11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..327		6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158819
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1661
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	1	1.000	-	-		FOG0000490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.760