DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS and MARS1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens

Alignment Length:	917	Identity:	452/917 - (49%)
Similarity:	589/917 - (64%)	Gaps:	65/917 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLNDAKYKDLLV-------LPTLELDNGLRLFSP 58
            |.::.:||.|..|.:|..|..|:...:|.:..:..   :|.:|       :|.|:||:|..|||.
Human     1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGP---EDCVVPFLTRPKVPVLQLDSGNYLFST 62

  Fly    59 AAIAKYLFVGKGQQRD----EWLEWSATLLAPALA---HHMAVGHKADANALPVLNALVKKLDDK 116
            :||.:|.|:..|.::|    :||||.||.|.|||:   :::.|..|...:.|..:...:..:|..
Human    63 SAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHS 127

  Fly   117 L--KATPYLAGDKPSAADIAIWSLLAPDGTLKG----AQNVDNLRDWYGRVKALPEVQEVLAEQP 175
            |  :..|:|||:..|.|||.:|..|.|  .|:.    .:.:..|..|:         |.:..::|
Human   128 LSRQNCPFLAGETESLADIVLWGALYP--LLQDPAYLPEELSALHSWF---------QTLSTQEP 181

  Fly   176 LKDLSFNALQQSNRYGGLHHVPL--KRLSLADASKLLVDTTPTVAD--TVTNEEISAAKAAF--- 233
            .:..:...|:|.   |.|...|.  |:...:.|....|...|...:  |::.|||:.|..|:
Human   182 CQRAAETVLKQQ---GVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKG 243

  Fly   234 TYTAPKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLI 298
            ..:.|....::..|||..|||||||||||||||||||||||||||||||::|||||...:|||.:
Human   244 LESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYL 308

  Fly   299 CGTDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDV 363
            |||||||||||.|||.|.|||:||||||..:|..|||||.|.||.||||||.:||.|.|:.|:.:
Human   309 CGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQL 373

  Fly   364 LKAGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCK 428
            ||.|:::.::||||.|:.|.||||||||||.||.  ||||:||||||||||||:||.||.:|:||
Human   374 LKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPF--CGYEEARGDQCDKCGKLINAVELKKPQCK 436

  Fly   429 VCNSAPVLRSSDQLFIDLPKAEPQLKEWVDKSEGG--WTHNAKVITRAWLKEGLKPRCITRDLKW 491
            ||.|.||::||..||:||||.|.:|:||:.::..|  ||.||:.|||:||::|||||||||||||
Human   437 VCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKW 501

  Fly   492 GIPVPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVW 556
            |.|||.||||.|||||||||..||:|:|..||.::::||:..:  .|:|:||||||||||||:|:
Human   502 GTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPE--QVDLYQFMAKDNVPFHSLVF 564

  Fly   557 PSVLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQ 621
            |...|.....:|||||::|||||||||||||||||:||||:.||:||||||:|||||...|||||
Human   565 PCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQ 629

  Fly   622 DSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELVLLALINRELRGYIN 686
            ||:|||.||..:||||||||||||:|||.:|..|.|...||.::.|.|:..|||.:..||:.|..
Human   630 DSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQ 694

  Fly   687 SMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPY 751
            .:||.::||.:|.:|.||||||.|:|..:||..:||::..:.||.|:.||.||||.||:.:|.||
Human   695 LLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPY 759

  Fly   752 MPTTARTLFGQLNAKQTPLNAEKPLVT---LLLPAGHQIGKPAPLFAKLEQSFIDELKGKYGGAQ 813
            |||.:.|:..||   |.|..|...|:|   ..||||||||..:|||.|||...|:.|:.::||.|
Human   760 MPTVSATIQAQL---QLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQ 821

  Fly   814 ATNDAAHSQISAADLEKAVQAQA---------DKVRELKASTKDKAIWQPEVTKLLDLKKQLEEA 869
            |......:.:......|..|.||         :.||||||...||.....||.|||||||||..|
Human   822 AKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVA 886

  Fly   870 KKKTATA 876
            :.|...|
Human   887 EGKPPEA 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698	55/193 (28%)
		GST_N_family	1..65	CDD:238319	21/70 (30%)
		GST_C_family	63..164	CDD:295467	33/113 (29%)
		PRK12268	254..812	CDD:237029	346/562 (62%)
		MetRS_core	255..625	CDD:173907	252/371 (68%)
		Anticodon_Ia_Met	634..763	CDD:153411	64/128 (50%)
		MetRS_RNA	828..868	CDD:238475	23/48 (48%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	13/43 (30%)
		GstA	<47..189	CDD:223698	45/152 (30%)
		GST_C_MetRS_N	77..179	CDD:198340	31/112 (28%)
		PRK12268	264..819	CDD:237029	345/561 (61%)
		MetRS_core	265..633	CDD:173907	252/371 (68%)
		'HIGH' region	273..283		9/9 (100%)
		'KMSKS' region	593..597		3/3 (100%)
		Anticodon_Ia_Met	642..771	CDD:153411	64/128 (50%)
		MetRS_RNA	845..889	CDD:238475	20/43 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159863
Domainoid	1	1.000	583	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90878
Inparanoid	1	1.050	815	1.000	Inparanoid score	I480
Isobase	1	0.950	-	0	Normalized mean entropy	S822
OMA	1	1.010	-	-		QHG62211
OrthoDB	1	1.010	-	-		D279987at33208
OrthoFinder	1	1.000	-	-		FOG0004295
OrthoInspector	1	1.000	-	-		oto91771
orthoMCL	1	0.900	-	-		OOG6_101454
Panther	1	1.100	-	-	LDO	PTHR45765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720