Protein Alignment MetRS and IleRS-m

DIOPT Version :9

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: NP_648837.2
• Gene: IleRS-m / 39762
• FlyBaseID: FBgn0036569
• Length: 941
• Species: Drosophila melanogaster
• Alignment Length: 1151
• Identity: 209/1151 - (18%)
• Similarity: 352/1151 - (30%)
• Gaps: 418/1151 - (36%)

  Fly     2 IIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLNDAKYKDLLVLPTLELDNGLRLFSPAAIAKYLF 66
            |.|...||     .|...|.||:..:         ||.|.:.||..:..|.|.
  Fly     4 IFYFRVGN-----RLYSMKAAKKDAK---------KYTDTINLPKTKFPNRLT------------ 42

  Fly    67 VGKGQQRDEWLEWSATLLAPALAHHMAVGHKADANALPVLNALVKKLDDKLKATPYLAGDKPSAA 131
            ..|.::::..:          |.:.:||.:....          ::|.:|.|.| ::..|.|..|
  Fly    43 AAKREEQERLV----------LENKIAVSYAYQE----------QRLAEKGKPT-FVLHDGPPYA 86

  Fly   132 DIAIWSLLAPDGTLKGAQNVDNLRDWYGRVKALPEVQEVLAEQPLKDLSFNALQQSNRYG----- 191
                      :|.|.....|:.:                     |||::   |:|...:|
  Fly    87 ----------NGQLHMGHAVNKI---------------------LKDIT---LRQRVAHGQRVNY 117

  Fly   192 ----GLHHVPLKRLSLADASKLLVDTTPTVADTVTNEEISAAKAAFTYTAPKEIKEE-------- 244
                ..|.:|::           :..|.| |...:.:||.....||.:.|.|..|||
  Fly   118 IPGWDCHGLPIE-----------LKATST-APGQSAQEIRQKSRAFAWEAIKSQKEEFSSWGILA 170

  Fly   245 ---------------------------------RTVLP---KPGERNVLITSALPYVNNVPHLGN 273
                                             |.:.|   .|..|..|..:.|.|..|  |
  Fly   171 NWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDAN--H--- 230

  Fly   274 IIGCVLSADIYARYS-RSAGYNT------LLICGTDEYGTATENKALAENLTPREIC-------- 323
                 :|..:|.|:: ..:.::.      .|:..|..: |...|:|:..|.:...:.
  Fly   231 -----ISPSVYVRFALNPSSFDVKDKQIYALVWTTTPW-TLPSNQAICYNASLEYVIVRLSDRNQ 289

  Fly   324 DKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLK----------------------- 365
            |:.:.:.:|:...|        ...||.:.:|||....::|.
  Fly   290 DELYLMASALMADF--------EANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNLPFFDASHV 346

  Fly   366 -----AGYIITE----------SVEQLLCQKCDRFLADRFV--EGTCPHPGCGYEDARGDQ-CDK 412
                 .|.:.|.          |:.|.:..||       ||  |||.......:  .||.. .|:
  Fly   347 QDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKC-------FVNEEGTYTKEAPDF--LRGKSVLDQ 402

  Fly   413 CGKLV--NATELIRPRCKVCNSAP---------VLRSSDQLFIDLPKAEPQLKEWVDKSEGGWTH 466
            ...||  ...|.:....|:.:|.|         ::|:|:|.||:..|.:....:.:::.|.....
  Fly   403 GNSLVLDRIAEDVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPRA 467

  Fly   467 NAKVITRAWLKEGLKPR---CITRDLKWGIPVPHEGFEKKVFY-------VWFDAPFGYVSMTKR 521
            ||:...:|.|.: |:.|   ||:|...||:|:|       |.|       |...|...::....|
  Fly   468 NAEASKKALLTQ-LQKRPYWCISRQRAWGVPIP-------VLYSRESGKVVLNSALIEHLCNLLR 524

  Fly   522 YTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVLLAINKGHTLVSHIMATEYLN--YEDG 584
            .......||..:           .::.||.|        |.....|.....:..|:.|:  ::.|
  Fly   525 KEGSIDFWWVKS-----------VEELVPEH--------LLRELHHEAKDLVKGTDILDIWFDSG 570

  Fly   585 KFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSFSW------NDLAAR---------- 633
                |....|.|.|.             :|....||.|....|      ..:|||
  Fly   571 ----STWSAVLGKDK-------------IADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFV 618

  Fly   634 -------NNSELLNNLGNFVNRALVFCEKNFSS-----------TVPGVITTQDELVLLALIN-- 678
                   ...::..:|||.::...:  .|.:.:           |....||..|:|:..|..|
  Fly   619 HGFTVDEKGYKMSKSLGNVISPKQI--TKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAENLC 681

  Fly   679 ------RELRGYINSMEKAK--LRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDD-----QKTRA 730
                  |.|:|.|...:..:  :|...:..|      |.|:.||    |::...:     |....
  Fly   682 KIRGTMRYLKGVIGEKQSGEKLIRTSDKSYL------NRYLLSQ----LVEFESEVEKLYQAYEY 736

  Fly   731 STIIGLCVNIACLLANLLFPYMPTTARTLFGQ----LNAKQTPLNAEKPLVTLLLPAGHQIGKPA 791
            :.::....|......:.::.:: ...|...|.    |..:||..:..:.|...|.|.       .
  Fly   737 NRVVACVQNFIANQVSAVYVHL-IKDRLYCGDDHELLAIRQTLTHCYQQLCKSLWPI-------V 793

  Fly   792 PLFAKLEQSFIDELKGKYGGAQATNDAAHSQISAADLE-------KAVQAQADKVRELKASTKDK 849
            |...:...|:.|          .|..|.|.||...:.|       :.:.|..|..|.:.....|.
  Fly   794 PFLVEESWSYYD----------TTGGAFHEQIVQTNPEWQDTKATEVINAAFDVKRLINQQAGDV 848

  Fly   850 AIWQPEVT------KLLDLKKQLEEAKKKTATAAAPAATPAPSNGSQSVQDLEKAIQEQGDKVRK 908
            ..|...||      ..|||.::|.                :|...|.|..:|.:.:|.  ..|..
  Fly   849 NTWHLAVTIKGKERSQLDLLRELH----------------SPLGESVSNSELCEILQV--GSVTL 895

  Fly   909 LKGSTKDKTVWQPEVNILL-------DLKKQLEAVQKAAKAAPAAN 947
            |:....|..:...::.|.|       .|:.:.:..|:.:....|.|
  Fly   896 LQSHNSDLDIALSKLQISLCPRCRRYGLEDEQKTCQRCSDVMEAKN 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698	29/172 (17%)
		GST_N_family	1..65	CDD:238319	15/62 (24%)
		GST_C_family	63..164	CDD:295467	14/100 (14%)
		PRK12268	254..812	CDD:237029	126/689 (18%)
		MetRS_core	255..625	CDD:173907	86/448 (19%)
		Anticodon_Ia_Met	634..763	CDD:153411	26/158 (16%)
		MetRS_RNA	828..868	CDD:238475	12/52 (23%)
		MetRS_RNA	895..938	CDD:238475	8/49 (16%)
		MetRS_RNA	966..1009	CDD:238475
IleRS-m	NP_648837.2	ileS	26..938	CDD:235588	198/1110 (18%)
		nt_trans	75..>211	CDD:294020	29/182 (16%)
		nt_trans	<434..658	CDD:294020	51/269 (19%)
		Anticodon_Ia_Ile_BEm	668..842	CDD:153414	37/201 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840