DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS and LeuRS-m

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster

Alignment Length:	933	Identity:	187/933 - (20%)
Similarity:	294/933 - (31%)	Gaps:	349/933 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 EWLEWSATLLAPALAHHMAVGHKADANALPVLNALVKKLDDKLKAT--PYLAGDKPSAADIAIWS 137
            ::.:|:..|......|.:|..::|..|..||...::  .|:::.|.  .:.:|.|.....:..|.
  Fly   160 KYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVL--ADEQVDANGCSWRSGAKVEKKLLRQWF 222

  Fly   138 LLA-----------PDGTLKGAQNVDNL-RDWYGR--------VKALPEVQEVLAEQP--LKDLS 180
            :..           .|.||:..:::.|| |.|.|.        :.:...:..|....|  |||..
  Fly   223 IRTSAYAKQLLDGLEDPTLRDWRDIINLQRHWIGECDGYAFNLLTSASGLLRVWTTHPEHLKDPH 287

  Fly   181 FNALQQSNRYGGLHHVPLKRLSLADASKLLVDTTPTVADTVTNEEISAAKAAFTYTAPKEIKEER 245
            ...:.:||     ||  |.:|..||:                   :|||......|.|....:|.
  Fly   288 AFLVLRSN-----HH--LSKLKGADS-------------------LSAANPFAGTTMPVVFSDEV 326

  Fly   246 TVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTDEYGTA-TE 309
            |..||                              :|:|.......|.:..|   .|.||.| |.
  Fly   327 TFPPK------------------------------SDVYLAAPSFRGEDKDL---WDSYGLAFTS 358

  Fly   310 NKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKA-------G 367
            |....|:|:|.              .|                    :...|:||:|       |
  Fly   359 NGKDEESLSPA--------------NW--------------------EMLRKEVLQAATRLNVGG 389

  Fly   368 YIITESVEQLL---------------CQKC---------------------DRFLADRFVEGTCP 396
            |.::..::..|               ||||                     :.||.|      ||
  Fly   390 YRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEEQLPVSLPPKDSPKEAFLCD------CP 448

  Fly   397 HPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNSAPVLRSSDQLFIDLPKAE-----PQLKEW 456
            .  ||.:||| .:.|.....|:            :|...||     ::|...:|     ...|::
  Fly   449 K--CGEKDAR-RETDTMDTFVD------------SSWYYLR-----YLDAQNSERIFDTALTKKF 493

  Fly   457 --VDKSEGGWTH------NAKVITRAWLKEGLKPRC--ITRDLKWGIPVPHEGFEKKVFYVWFDA 511
              ||...||..|      .|:.|.......||.|..  .:|.|..|: |....|.
  Fly   494 MPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQGM-VMGRSFR---------- 547

  Fly   512 PFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVLLAINKGHTLVSHIMAT 576
                |..:.||..|          |:||:..  ||.|            .|:.| .|....:|..
  Fly   548 ----VKGSGRYVPE----------TEVEIVN--AKKN------------QAVLK-ETKEPVVMTW 583

  Fly   577 EYLNYEDGKFSKSRGIGV--------FGNDAQETGIPADV-------WRFYLASARPEG------ 620
            |       |.|||:..||        :|.|.....|.|||       |    :||...|
  Fly   584 E-------KMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNW----SSATFPGILNWQK 637

  Fly   621 ------QDSSFSWNDLAARNNSELLNNLGNFV-NRALVFCEKNFSSTVPGVITTQDELVLLALIN 678
                  ||...:..|..|   |:::.....|: ..|.:|..:||  .|.|..........|::..
  Fly   638 RLWLTLQDFQQAREDQTA---SDVVPTSEEFLAEDAKLFDARNF--YVKGATFNYRHAQQLSVAI 697

  Fly   679 RELRGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACL 743
            .:::|..||     ||...:|:|   |||..:               ::..|:.||
  Fly   698 SKMQGLTNS-----LRRTPKHVL---RHGKQF---------------ERALAAQII--------- 730

  Fly   744 LANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVTLLLPAGHQIGKPAPLFAK----LEQSFIDE 804
               :|.|..|..|..|:.:..|....||          ||..::.....:.|:    ::.::..:
  Fly   731 ---MLAPMAPHFASELWSKFVAIPGRLN----------PASQELQWSEDVLAQRWPDIDPAYNLD 782

  Fly   805 LKGKYGG-------AQAT--NDAAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLL 860
            |..|..|       .|.|  :...||  .|.|:....::....:.:.|..|.:..:: |.:..:|
  Fly   783 LSIKVNGFENCVIKVQRTHLDKVTHS--DALDIAFNTESVTSYLIDKKIRTTNFVLY-PGIEAIL 844

  Fly   861 DLKKQLEEAKKKTATAAAPAATP 883
            ::.....:.|:|..|.....|.|
  Fly   845 NIYVDKAKMKQKPPTTDDAEAQP 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698	22/121 (18%)
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467	21/110 (19%)
		PRK12268	254..812	CDD:237029	129/655 (20%)
		MetRS_core	255..625	CDD:173907	91/455 (20%)
		Anticodon_Ia_Met	634..763	CDD:153411	27/129 (21%)
		MetRS_RNA	828..868	CDD:238475	4/39 (10%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	182/912 (20%)
		LeuRS_core	63..624	CDD:173906	128/631 (20%)
		Anticodon_Ia_like	624..747	CDD:299868	35/166 (21%)
		Anticodon_Ia_like	<723..799	CDD:299868	17/97 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840