Protein Alignment MetRS and Mars1

DIOPT Version :10

• Sequence 1: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Sequence 2: XP_006241513.1
• Gene: Mars1 / 299851
• RGDID: 1305321
• Length: 910
• Species: Rattus norvegicus
• Alignment Length: 961
• Identity: 450/961 - (46%)
• Similarity: 594/961 - (61%)
• Gaps: 96/961 - (9%)

  Fly     1 MIIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLNDAKYKDLLV-------LPTLELDNGLRLFSP 58
            |.::.::|:|..|.:|..|..|:...::.:..:..   ::.:|       :|.|:||:|..|||.
  Rat     1 MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGP---EECVVPFLTRPKVPVLQLDSGNYLFSA 62

  Fly    59 AAIAKYLFVGKGQQRD----EWLEWSATLLAPALA---HHMAVGHKADANALPVLNALVKKLDDK 116
            :||.:|.|:..|.::|    :||||.||.|.|.|:   :.:.|..|...:.|..|..::..:|..
  Rat    63 SAICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHS 127

  Fly   117 L--KATPYLAGDKPSAADIAIWSLLAPDGTLKG----AQNVDNLRDWYGRVKALPEVQEVLAEQP 175
            |  :..|:||||..|.|||.:|..|.|  .|:.    .:.:..|:.|:..:......|.. ||..
  Rat   128 LSRQNCPFLAGDTESLADIVLWGALYP--LLQDPAYLPEELGALQSWFQTLSTQEPCQRA-AETV 189

  Fly   176 LKDLSFNALQQSNRYGGLHHVPLKRLSLADASKLLVDTTPTVADTVTNEEISAAKAAF---TYTA 237
            ||.....||:..     |...|..:....:...:..:.......|::.|:|.||.||:   ....
  Rat   190 LKQQGVLALRPY-----LQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENL 249

  Fly   238 PKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTD 302
            |....::..|||.||||||||||||||||||||||||||||||||::|||||...:|||.:||||
  Rat   250 PPLQPQQHPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTD 314

  Fly   303 EYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAG 367
            |||||||.||:.|.|||:||||||..:|..|||||.|.||.||||||..||.|.|:.|:.:|..|
  Rat   315 EYGTATETKAMEEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRG 379

  Fly   368 YIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNS 432
            :::.::||||.|::|.||||||||||.||.  ||||:||||||||||||:||.||.||:||||.|
  Rat   380 FVLQDTVEQLRCEQCARFLADRFVEGVCPF--CGYEEARGDQCDKCGKLINAIELKRPQCKVCRS 442

  Fly   433 APVLRSSDQLFIDLPKAEPQLKEWVDKSEGG--WTHNAKVITRAWLKEGLKPRCITRDLKWGIPV 495
            .||::||..||:||||.|.:|::|:.|:..|  ||.||:.|.|:||::||||||||||||||.||
  Rat   443 HPVVKSSKHLFLDLPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPV 507

  Fly   496 PHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVL 560
            |.||||.|||||||||..||:|:|..||.::::||:..:  .|:|:|||||||||||.:|:|...
  Rat   508 PLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPE--QVDLYQFMAKDNVPFHGLVFPCSA 570

  Fly   561 LAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSF 625
            |.....:|||.:::||||||||||||||||||||||:.||:||||||:|||||...|||||||:|
  Rat   571 LGAEDNYTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAF 635

  Fly   626 SWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELVLLALINRELRGYINSMEK 690
            ||.||..:||||||||||||:|||.:|..|.|...||.::.|.|:..|:|.::.||:.|...:||
  Rat   636 SWTDLLIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEK 700

  Fly   691 AKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTT 755
            .::||.:|.:|.||||||.|:|..:||..:||.:..:.||.|:.|:.||||.||:.:|.|||||.
  Rat   701 VRIRDALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTV 765

  Fly   756 ARTLFGQLNAKQTPLNAEKPLVT---LLLPAGHQIGKPAPLFAKLEQSFIDELKGKYGGAQATND 817
            :.|:..||   |.|..|.:.|.|   ..|||||:||..:|||.|||...|:.|:.::||.|
  Rat   766 SSTIQTQL---QLPEAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQ---- 823

  Fly   818 AAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLLDLKKQLEEAKKKTATAAAPAAT 882
                      ||::::.||      |.|.|                           .|...|.|
  Rat   824 ----------LEESLELQA------KGSPK---------------------------PAVVEAVT 845

  Fly   883 PAPSNGSQSVQDLEKAIQEQGDKVRKLKGSTKDKTVWQPEVNILLDLKKQL 933
            .|   |||.:|.|...:.:||:.||:||....||.....||..||||||||
  Rat   846 TA---GSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQL 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537	20/75 (27%)
		GST_C_family	63..164	CDD:470672	34/113 (30%)
		PLN02610	248..>850	CDD:215329	353/606 (58%)
		MetRS_RNA	895..938	CDD:238475	19/39 (49%)
		MetRS_RNA	966..1009	CDD:238475
Mars1	XP_006241513.1	GST_N_5	1..74	CDD:436537	20/75 (27%)
		GST_C_MetRS_N	77..179	CDD:198340	31/103 (30%)
		PLN02610	258..>839	CDD:215329	354/634 (56%)
		MetRS_RNA	855..899	CDD:238475	19/39 (49%)