DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS and Mars1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_006241513.1	Gene:	Mars1 / 299851	RGDID:	1305321	Length:	910	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	450/961 - (46%)
Similarity:	594/961 - (61%)	Gaps:	96/961 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLNDAKYKDLLV-------LPTLELDNGLRLFSP 58
            |.::.::|:|..|.:|..|..|:...::.:..:..   ::.:|       :|.|:||:|..|||.
  Rat     1 MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGP---EECVVPFLTRPKVPVLQLDSGNYLFSA 62

  Fly    59 AAIAKYLFVGKGQQRD----EWLEWSATLLAPALA---HHMAVGHKADANALPVLNALVKKLDDK 116
            :||.:|.|:..|.::|    :||||.||.|.|.|:   :.:.|..|...:.|..|..::..:|..
  Rat    63 SAICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHS 127

  Fly   117 L--KATPYLAGDKPSAADIAIWSLLAPDGTLKG----AQNVDNLRDWYGRVKALPEVQEVLAEQP 175
            |  :..|:||||..|.|||.:|..|.|  .|:.    .:.:..|:.|:..:......|.. ||..
  Rat   128 LSRQNCPFLAGDTESLADIVLWGALYP--LLQDPAYLPEELGALQSWFQTLSTQEPCQRA-AETV 189

  Fly   176 LKDLSFNALQQSNRYGGLHHVPLKRLSLADASKLLVDTTPTVADTVTNEEISAAKAAF---TYTA 237
            ||.....||:..     |...|..:....:...:..:.......|::.|:|.||.||:   ....
  Rat   190 LKQQGVLALRPY-----LQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENL 249

  Fly   238 PKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTD 302
            |....::..|||.||||||||||||||||||||||||||||||||::|||||...:|||.:||||
  Rat   250 PPLQPQQHPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTD 314

  Fly   303 EYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAG 367
            |||||||.||:.|.|||:||||||..:|..|||||.|.||.||||||..||.|.|:.|:.:|..|
  Rat   315 EYGTATETKAMEEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRG 379

  Fly   368 YIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNS 432
            :::.::||||.|::|.||||||||||.||.  ||||:||||||||||||:||.||.||:||||.|
  Rat   380 FVLQDTVEQLRCEQCARFLADRFVEGVCPF--CGYEEARGDQCDKCGKLINAIELKRPQCKVCRS 442

  Fly   433 APVLRSSDQLFIDLPKAEPQLKEWVDKSEGG--WTHNAKVITRAWLKEGLKPRCITRDLKWGIPV 495
            .||::||..||:||||.|.:|::|:.|:..|  ||.||:.|.|:||::||||||||||||||.||
  Rat   443 HPVVKSSKHLFLDLPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPV 507

  Fly   496 PHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVL 560
            |.||||.|||||||||..||:|:|..||.::::||:..:  .|:|:|||||||||||.:|:|...
  Rat   508 PLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPE--QVDLYQFMAKDNVPFHGLVFPCSA 570

  Fly   561 LAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSF 625
            |.....:|||.:::||||||||||||||||||||||:.||:||||||:|||||...|||||||:|
  Rat   571 LGAEDNYTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAF 635

  Fly   626 SWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELVLLALINRELRGYINSMEK 690
            ||.||..:||||||||||||:|||.:|..|.|...||.::.|.|:..|:|.::.||:.|...:||
  Rat   636 SWTDLLIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEK 700

  Fly   691 AKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTT 755
            .::||.:|.:|.||||||.|:|..:||..:||.:..:.||.|:.|:.||||.||:.:|.|||||.
  Rat   701 VRIRDALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTV 765

  Fly   756 ARTLFGQLNAKQTPLNAEKPLVT---LLLPAGHQIGKPAPLFAKLEQSFIDELKGKYGGAQATND 817
            :.|:..||   |.|..|.:.|.|   ..|||||:||..:|||.|||...|:.|:.::||.|
  Rat   766 SSTIQTQL---QLPEAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQ---- 823

  Fly   818 AAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLLDLKKQLEEAKKKTATAAAPAAT 882
                      ||::::.||      |.|.|                           .|...|.|
  Rat   824 ----------LEESLELQA------KGSPK---------------------------PAVVEAVT 845

  Fly   883 PAPSNGSQSVQDLEKAIQEQGDKVRKLKGSTKDKTVWQPEVNILLDLKKQL 933
            .|   |||.:|.|...:.:||:.||:||....||.....||..||||||||
  Rat   846 TA---GSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698	55/193 (28%)
		GST_N_family	1..65	CDD:238319	18/70 (26%)
		GST_C_family	63..164	CDD:295467	34/113 (30%)
		PRK12268	254..812	CDD:237029	339/562 (60%)
		MetRS_core	255..625	CDD:173907	248/371 (67%)
		Anticodon_Ia_Met	634..763	CDD:153411	62/128 (48%)
		MetRS_RNA	828..868	CDD:238475	7/39 (18%)
		MetRS_RNA	895..938	CDD:238475	19/39 (49%)
		MetRS_RNA	966..1009	CDD:238475
Mars1	XP_006241513.1	Thioredoxin_like	1..68	CDD:294274	18/69 (26%)
		GstA	<47..189	CDD:223698	47/144 (33%)
		GST_C_MetRS_N	77..179	CDD:198340	31/103 (30%)
		PRK12268	266..821	CDD:237029	338/561 (60%)
		MetRS_core	267..635	CDD:173907	248/371 (67%)
		Anticodon_Ia_Met	644..773	CDD:153411	62/128 (48%)
		MetRS_RNA	855..899	CDD:238475	19/39 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353926
Domainoid	1	1.000	571	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90878
Inparanoid	1	1.050	800	1.000	Inparanoid score	I475
OMA	1	1.010	-	-		QHG62211
OrthoDB	1	1.010	-	-		D279987at33208
OrthoFinder	1	1.000	-	-		FOG0004295
OrthoInspector	1	1.000	-	-		oto98838
orthoMCL	1	0.900	-	-		OOG6_101454
Panther	1	1.100	-	-	LDO	PTHR45765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3028
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770