DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS and Mars1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_001165053.1	Gene:	Mars1 / 216443	MGIID:	1345633	Length:	910	Species:	Mus musculus

Alignment Length:	979	Identity:	453/979 - (46%)
Similarity:	601/979 - (61%)	Gaps:	132/979 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIIYTNDGNPLGLQLLMLAKFAKQPVQVQLVNLNDAKYKDLLV-------LPTLELDNGLRLFSP 58
            |.::.::|:|..|.:|..|..|:...::.:..:..   ::.:|       :|.|:||:|..|||.
Mouse     1 MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGP---EECVVPFLTRPKVPVLQLDSGNYLFSA 62

  Fly    59 AAIAKYLFVGKGQQRD----EWLEWSATLLAPALA---HHMAVGHKADANALPVLNALVKKLDDK 116
            :||.:|.|:..|.::|    :||||.||.|.|.|:   |.:.|..|...:.|..|..::..:|..
Mouse    63 SAICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALHCLVVQGKKGEDILGPLRRVLTHIDHS 127

  Fly   117 L--KATPYLAGDKPSAADIAIWSLLAPDGTLKG----AQNVDNLRDWYGRVKALPEVQEVLAEQP 175
            |  :..|:||||..|.|||.:|..|.|  .|:.    .:.:..|:.|:         |.:..::|
Mouse   128 LSRQNCPFLAGDTESLADIVLWGALYP--LLQDPAYLPEELGALQSWF---------QTLSTQEP 181

  Fly   176 LKDLSFNALQQSNRYGGLHHVPLKRLSLADASKLLVDTTP----------TVAD--------TVT 222
            .:..:...|:|.   |.|            |.:|.:...|          ||::        |::
Mouse   182 CQRAAETVLKQQ---GVL------------ALRLYLQKQPQPQPPPPEGRTVSNELEEEELATLS 231

  Fly   223 NEEISAAKAAF---TYTAPKEIKEERTVLPKPGERNVLITSALPYVNNVPHLGNIIGCVLSADIY 284
            .|:|..|.||:   ..:.|....::..|||.||||||||||||||||||||||||||||||||::
Mouse   232 EEDIVTAVAAWEKGLESLPPLKLQQHPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVF 296

  Fly   285 ARYSRSAGYNTLLICGTDEYGTATENKALAENLTPREICDKYFELHNAIYRWFGIGFDYFGRTTT 349
            |||.|...:|||.:|||||||||||.||:.|.||||||||||..:|..|||||||.||.||||||
Mouse   297 ARYCRLRQWNTLYLCGTDEYGTATETKAMEEGLTPREICDKYHAIHADIYRWFGISFDTFGRTTT 361

  Fly   350 QEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCDRFLADRFVEGTCPHPGCGYEDARGDQCDKCG 414
            .:||.|.|:.|:.:|..|:::.::||||.|::|.||||||||||.||.  ||||:|||||||:||
Mouse   362 PQQTKITQDIFQRLLTRGFVLRDTVEQLRCERCARFLADRFVEGVCPF--CGYEEARGDQCDRCG 424

  Fly   415 KLVNATELIRPRCKVCNSAPVLRSSDQLFIDLPKAEPQLKEWVDKSEGG--WTHNAKVITRAWLK 477
            ||:||.||.:|:||:|.|.||:|||..||:||||.|.:|::|:.|:..|  ||.||:.|.|:||:
Mouse   425 KLINAIELKKPQCKICRSCPVVRSSQHLFLDLPKLEKRLEDWLGKTVPGSDWTPNARFIIRSWLR 489

  Fly   478 EGLKPRCITRDLKWGIPVPHEGFEKKVFYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQ 542
            :||||||||||||||.|||.||||.|||||||||..||||:|..||.::::||:..:  .|:|:|
Mouse   490 DGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYVSITANYTDQWEKWWKNPE--QVDLYQ 552

  Fly   543 FMAKDNVPFHSVVWPSVLLAINKGHTLVSHIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPAD 607
            ||||||||||.:|:|..:|.....:|||.||:||||||||||||||||||||||:.|::||||||
Mouse   553 FMAKDNVPFHGLVFPCSVLGAEDNYTLVKHIIATEYLNYEDGKFSKSRGIGVFGDMAKDTGIPAD 617

  Fly   608 VWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELV 672
            :|||||...|||||||:|||.||..:||||||||||||:|||.:|..|.|...||.:..|.|:..
Mouse   618 IWRFYLLYIRPEGQDSAFSWTDLLIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMALTPDDRR 682

  Fly   673 LLALINRELRGYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLC 737
            |:|.::.||:.|...:||.::||.:|.:|.||||||.|:|..:||..:||.:..:.||.|:.|:.
Mouse   683 LVAHVSWELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGGEMDRQRAGTVTGMA 747

  Fly   738 VNIACLLANLLFPYMPTTARTLFGQLNAKQTPLNAEKPLVT---LLLPAGHQIGKPAPLFAKLEQ 799
            ||:|.||:.:|.|||||.:.|:..||   |.|..|.:.|.|   ..|||||:||..:|||.|||.
Mouse   748 VNMAALLSVMLQPYMPTVSSTIQTQL---QLPPAACRILATSFICTLPAGHRIGTVSPLFQKLEN 809

  Fly   800 SFIDELKGKYGGAQATNDAAHSQISAADLEKAVQAQADKVRELKASTKDKAIWQPEVTKLLDLKK 864
            ..|:.|:.::||.|              ||:::        ||||....|
Mouse   810 DQIENLRQRFGGGQ--------------LEESL--------ELKAKGSPK--------------- 837

  Fly   865 QLEEAKKKTATAAAPAATPAPSNGSQSVQDLEKAIQEQGDKVRKLKGSTKDKTVWQPEVNILLDL 929
                      .||..|.|.|   |||.:|.|...:.:||:.||:||....||.....||..||||
Mouse   838 ----------PAAVEAVTAA---GSQHIQTLTDEVTKQGNVVRELKAQKADKNQVAAEVAKLLDL 889

  Fly   930 KKQL 933
            ||||
Mouse   890 KKQL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698	54/193 (28%)
		GST_N_family	1..65	CDD:238319	18/70 (26%)
		GST_C_family	63..164	CDD:295467	35/113 (31%)
		PRK12268	254..812	CDD:237029	339/562 (60%)
		MetRS_core	255..625	CDD:173907	249/371 (67%)
		Anticodon_Ia_Met	634..763	CDD:153411	61/128 (48%)
		MetRS_RNA	828..868	CDD:238475	7/39 (18%)
		MetRS_RNA	895..938	CDD:238475	19/39 (49%)
		MetRS_RNA	966..1009	CDD:238475
Mars1	NP_001165053.1	Thioredoxin_like	1..68	CDD:294274	18/69 (26%)
		GstA	<47..189	CDD:223698	47/152 (31%)
		GST_C_MetRS_N	77..179	CDD:198340	33/112 (29%)
		PRK12268	266..821	CDD:237029	338/561 (60%)
		MetRS_core	267..635	CDD:173907	249/371 (67%)
		'HIGH' region	275..285		9/9 (100%)
		'KMSKS' region	595..599		3/3 (100%)
		Anticodon_Ia_Met	644..773	CDD:153411	61/128 (48%)
		MetRS_RNA	855..899	CDD:238475	19/39 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850232
Domainoid	1	1.000	578	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90878
Inparanoid	1	1.050	806	1.000	Inparanoid score	I490
Isobase	1	0.950	-	0	Normalized mean entropy	S822
OMA	1	1.010	-	-		QHG62211
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004295
OrthoInspector	1	1.000	-	-		oto95351
orthoMCL	1	0.900	-	-		OOG6_101454
Panther	1	1.100	-	-	LDO	PTHR45765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1449
SonicParanoid	1	1.000	-	-		X3028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740