DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS and Aimp1

DIOPT Version :9

Sequence 1:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	NP_446209.1	Gene:	Aimp1 / 114632	RGDID:	620466	Length:	315	Species:	Rattus norvegicus

Alignment Length:	271	Identity:	53/271 - (19%)
Similarity:	97/271 - (35%)	Gaps:	91/271 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   808 KYGGAQATNDAAHSQISAADLEKAVQ--AQADKVRE-LK---ASTKDKAIWQP---EVTKL---- 859
            ::.|..|||||.        |::..|  |:||::.| ||   |..|:|||.|.   |..||
  Rat     5 RFWGKMATNDAV--------LKRLEQKGAEADQIIEYLKQQVALLKEKAILQATLREEKKLQVEN 61

  Fly   860 LDLKKQLEEAKK-----------------------------KTATAAAPAATPAPSNGSQSVQDL 895
            ..|||::||.|:                             ::.|.:|...|...:.|....:.:
  Rat    62 AKLKKEIEELKQELIQAEIHNGVKQVPVPSSSSLETHCSVSESVTRSASVTTTTMTGGGGEEKKV 126

  Fly   896 EKAIQEQGDKVRKLKGSTKDKTVWQP--------EVNILLDLKKQLEAVQKAAKAAPAANAAPAA 952
            ::..:::|:|..|.:.|.......:|        .:..::..||..:|.....:......|||..
  Rat   127 KEKTEKKGEKKEKKQQSAAASADSKPVDVSRLDLRIGCIVTAKKHPDADSLYVEEVDVGEAAPRT 191

  Fly   953 SPAATADAAKVKALEDKI-----------------------AQQAEKVRTL----------KATG 984
            ..:...:...::.:::::                       |...|||..|          :.|.
  Rat   192 VVSGLVNHVPLEQMQNRMVVLLCNLKPAKMRGVLSQAMVMCASSPEKVEILAPPNGSVPGDRITF 256

  Fly   985 DAAVWKPEVDI 995
            ||...:|:.::
  Rat   257 DAFPGEPDKEL 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS	NP_611382.1	GstA	1..175	CDD:223698
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467
		PRK12268	254..812	CDD:237029	0/3 (0%)
		MetRS_core	255..625	CDD:173907
		Anticodon_Ia_Met	634..763	CDD:153411
		MetRS_RNA	828..868	CDD:238475	20/52 (38%)
		MetRS_RNA	895..938	CDD:238475	8/50 (16%)
		MetRS_RNA	966..1009	CDD:238475	9/63 (14%)
Aimp1	NP_446209.1	Cnn_1N	<31..79	CDD:285263	18/47 (38%)
Aimp1	NP_446209.1	tRNA_bind_EMAP-II_like	153..255	CDD:239198	11/101 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900