Protein Alignment CG15099 and DOP1B

DIOPT Version :9

• Sequence 1: NP_001261081.1
• Gene: CG15099 / 37176
• FlyBaseID: FBgn0034400
• Length: 2683
• Species: Drosophila melanogaster
• Sequence 2: NP_001307643.1
• Gene: DOP1B / 9980
• HGNCID: 1291
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 2813
• Identity: 804/2813 - (28%)
• Similarity: 1259/2813 - (44%)
• Gaps: 753/2813 - (26%)

  Fly     9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73
            |||:|:.:.:||:|.:.|:|||||||.|||||||||:||||:||:.||.:|.::||||.|:||||
Human     4 EEQELLNDYRYRSYSSVIEKALRNFESSSEWADLISSLGKLNKALQSNLRYSLLPRRLLISKRLA 68

  Fly    74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137
            ||:||||||||||||||||.:||...|.:.||.: |:||.||||||.:||::|||.||.:||.||
Human    69 QCLHPALPSGVHLKALETYEIIFKIVGTKWLAKDLFLYSCGLFPLLAHAAVSVRPVLLTLYEKYF 133

  Fly   138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202
            :||...|.|:|..|:.|:|||.:.|.:..:|..|||.::...|....|||.||.||..:.:||||
Human   134 LPLQKLLLPSLQAFIVGLLPGLEEGSEISDRTDALLLRLSLVVGKEVFYTALWGSVLASPSIRLP 198

  Fly   203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVL--- 264
            |..:::.|.|:....:||.|::|.|.::.:.:|...|.||.:|||||.||.:|..||.:|.|
Human   199 ASVFVVGHINRDAPGREQKYMLGTNHQLTVKSLRASLLDSNVLVQRNNLEIVLFFFPFYTCLDSN 263

  Fly   265 -----LSEDDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEP 324
                 |...|:|::::....|:|||||||||||::|||||::..|:...::   :.||: .|::.
Human   264 ERAIPLLRSDIVRILSAATQTLLRRDMSLNRRLYAWLLGSDIKGNTVVPES---EISNS-YEDQS 324

  Fly   325 EPYFVKHSRHILIKALITTLRLSLECAPMD------LKPYRIMLSLLDKAEIGSAVLDYVLHDII 383
            ..:|.|:|:.:|::.|...|......|.::      |||:|:::|||||.|||..|:..:..::|
Human   325 SYFFEKYSKDLLVEGLAEILHQKFIDADVEERHHAYLKPFRVLISLLDKPEIGPQVVGNLFLEVI 389

  Fly   384 RAM---------------YISSGN------------AEALKSANLLFATFDPAYIWSYMTNMFE- 420
            ||.               |..|||            :|.:|:.|||..:....::|.|||..||
Human   390 RAFYSYCRDALGSDLKLSYTQSGNSLISAIKENRNASEIVKTVNLLITSLSTDFLWDYMTRCFEE 454

  Fly   421 --KACQQANSMQEKSQAGETSGKYACDVGSGDPCVLEICVLTEFLLETVSLEMYTETTRVYLPKV 483
              :..:|..|::...              |..|.|.|:|.|..|||:.:.||:|:|....|||:|
Human   455 CFRPVKQRYSVRNSV--------------SPPPTVSELCALLVFLLDVIPLELYSEVQTQYLPQV 505

  Fly   484 FLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSSDEKITMNSA 548
            ...:.|.|:..|:.:|..|:|.:||.|.|::|:||   ..|..|:  .|.:.|:||..|
Human   506 LGCLVQPLAEDMEALSLPELTHALKTCFKVLSKVQ---MPPSYLD--TESTSGTSSPVK------ 559

  Fly   549 SDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEEL----IHRSASNQSVGRQSPNKKK 609
                    |..|..:.::|              :..|.||:.    :....|...:...||...:
Human   560 --------GENGKIILETK--------------AVIPGDEDASFPPLKSEDSGIGLSASSPELSE 602

  Fly   610 AKSISRLSELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQSNTSA 674
            ...:.|:| |::|    |..::..|...|...|::|.|..           ..|::..:|...|.
Human   603 HLRVPRVS-LERD----DVWKKGGSMQRTFLCIQELIANF-----------ASKNIFGVQLTASG 651

  Fly   675 EVSDGPSAEEPK-SAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSRKLLHIESE 738
            |.|   .:|||. ....|.|.....::.||....                              |
Human   652 EES---KSEEPAGKRDRDGTQSLAANDSSRKNSW------------------------------E 683

  Fly   739 PKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQRLLNRS 803
            ||..:|. |.::..|.:.|:                                           |.
Human   684 PKPITVP-QFKQMLSDLFTA-------------------------------------------RG 704

  Fly   804 LPLPASASELSSDSEAQEEKQ-------QSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLV 861
            .|....:||..|.|.:...::       :.::||....|..:           |.|...|..||:
Human   705 SPFKTKSSESPSSSPSSPARKNGGEWDVEKVVIDLGGSREER-----------REAFAAACHLLL 758

  Fly   862 EMSTFPNCNKHVVLDKNEPE----------------LPNWLKVLCLVACFAQSDKELQVASITTL 910
            :.:|||     |.|.:.|.|                .|:|||.|..:.| ..:|..||..:|:||
Human   759 DCATFP-----VYLSEEETEQLCATLFQLPGAGDSSFPSWLKSLMTICC-CVTDCYLQNVAISTL 817

  Fly   911 FDLISLLRS---QIE----------HTTSPGVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWD 962
            .::|:..:|   .||          |....|...:|.:|.:..|.:..:.:.|..:|.|:.:||:
Human   818 LEVINHSQSLALVIEDKMKRYKSSGHNPFFGKLQMVTVPPIAPGILKVIAEKTDFYQRVARVLWN 882

  Fly   963 YLGTAGID-PAQIAALLHQLHSCL--ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQM 1024
            .|.....: ......|.::|| ||  .:.:.|.:|.:
Human   883 QLNKETREHHVTCVELFYRLH-CLAPTANICEDIICH---------------------------- 918

  Fly  1025 ERLAEAQLLCPTESTERLRESQARSFKKFELLWHLGRDKQTA------RGFEKTLLKVLDTLALP 1083
                  .||.|.:.|      :..:..:|.::|||.|:.|.:      |.|:::|..|||:||..
Human   919 ------ALLDPDKGT------RLEALFRFSVIWHLTREIQGSRVTSHNRSFDRSLFVVLDSLACT 971

  Fly  1084 HYMSERTFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQ------LYRESETEVTP 1142
            . .:.......||..:|..||:||:.:|:..:||...::|..|..::|      |:|....:.|
Human   972 D-GAIGAAAQGWLVRALSLGDVARILEPVLLLLLQPKTQRTSIHCLKQENSADDLHRWFNRKKT- 1034

  Fly  1143 AFERDVYAISSEQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDKSTVAT 1207
            :| |:..|:...|          .||:::..|:..|
Human  1035 SF-REACAVPEPQ----------ESGSEEHLPLSQF----------------------------- 1059

  Fly  1208 CSEATQDMNTIGLIINPLENANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPAN 1272
                                       |.::...|....::.|.:..|...:.|.|.|..   ..
Human  1060 ---------------------------TTVDREAIWAEVEKEPEKYPLRGELSEEELPYY---VE 1094

  Fly  1273 QPDNSLQYDQDITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGD---C----- 1329
            .||.:.....|.::|::|:|         ||....||...||.:..|.|::....:   |
Human  1095 LPDRTAHGAPDSSEHTESAD---------TSSCHTDSENTSSFSSPSHDLQELSNEENCCAPIPM 1150

  Fly  1330 -------ESVTDALTQHEKIKSRKTYRLTR---EKTPGENSLNSLEQKDHDSISELQADALPADE 1384
                   .|...|..|.|..|:.....|.|   :||....|.:|.|:.|    .||||
Human  1151 GGRAYPKRSALLAAFQSESFKAGAKLSLVRVDSDKTQASESFSSDEEAD----LELQA------- 1204

  Fly  1385 YFREDKKLGKRKKVLTSGEKKRLSCISKTSTDSNISGSHVEQPEQEEETEPGTESTINVEDKRRN 1449
                                                                             
Human  1205 ----------------------------------------------------------------- 1204

  Fly  1450 LSLETSKLQPDMQKTLEKGKQNVEILRQNNAAAAAAAAAAAEEQISVRSSMKSTVSLTDAAHLYH 1514
              |.||:|                 |:|..           |.|.:|.:..|
Human  1205 --LTTSRL-----------------LKQQR-----------ERQEAVEALFK------------- 1226

  Fly  1515 NHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFLCLSITTSFSSAS------LKQLLVRHRKSIS 1573
             |:|:||..||:|:.|||...|..::..:.:.|:.....||..::|      :..||.||::::.
Human  1227 -HILLYLQPYDSRRVLYAFSVLEAVLKTNPKEFIEAVSRTSMDTSSTAHLNLISNLLARHQEALI 1290

  Fly  1574 GKGFDGSVGNSEYAQGYRGC---MQLELLVTLCLFYARGYFQKESLDAQRQSPTLQDIVNNRRIQ 1635
            |:.|.|.:    ..|....|   :.||||..|||.:.|.|:......:.|      ||:.||.:|
Human  1291 GQSFYGKL----QTQVPNVCPHSLLLELLTYLCLSFLRSYYPCYLKVSHR------DILGNRDVQ 1345

  Fly  1636 LESIELLTLICSELIEIVKGMGRGLANYIADLLARAKLQKVMLHCLNSSVCS----YGLKGNTNS 1696
            ::|:|:|..|..:|:.:.|........:|..||.|.|:|:.:|..|::|:.:    |||....:.
Human  1346 VKSVEVLIRIMMQLVSVAKSSEGKNVEFIHSLLQRCKVQEFVLLSLSASMYTSQKRYGLATAHHG 1410

  Fly  1697 GSYAEQVL---SFNDPQDDQLHAD-CFQLQLLRLLLAVIRLEHEV---HQLRQDTPPAAGE-DSA 1753
            .:..|..|   |..:...||:.:: ..|::||:||..:|.|||.:   |:..::.|..:.| ..|
Human  1411 RALPEDSLFEESLINLGQDQIWSEHPLQIELLKLLQVLIVLEHHLGRAHEEAENQPDLSREWQRA 1475

  Fly  1754 GNASPTRLAEGATANVKYLPNCLISQQPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGS 1818
            .|      .:.|.:.::|:....::.|.:.::||:..||......:|..|..|||.||..|. .|
Human  1476 LN------FQQAISALQYVQPHPLTSQGLLVSAVVRGLQPAYGYGMHPAWVSLVTHSLPYFG-KS 1533

  Fly  1819 LTNIVISVVHQLCSNLD-----------RISKMGLPQQRHFPPDYVVSQLEALTILCHYCLLDNT 1872
            |...|...|.|:|.|||           ::|.....::.:..|||.::.||.||.:.|:|||:..
Human  1534 LGWTVTPFVVQICKNLDDLVKQYESESVKLSVSTTSKRENISPDYPLTLLEGLTTISHFCLLEQA 1598

  Fly  1873 QQTALSHLFNQAYPQTSSSAQSSSTGQLLNSIVHSFLSASESSTSAPAPRNPQLQAARNAVLSHL 1937
            .|                                     ::.:.:|..|.|  |:.||||:|..|
Human  1599 NQ-------------------------------------NKKTMAAGDPAN--LRNARNAILEEL 1624

  Fly  1938 PRIMSSVAAIWD---SELGQLRPV--------------------RQQLLEFLSPVSLHHGSNFLA 1979
            ||.::::|.:|:   .|..|.|||                    ||::|:||:|::.|.|....|
Human  1625 PRTVNTMALLWNVLRKEETQKRPVDLLGATKGSSSVYFKTTKTIRQKILDFLNPLTAHLGVQLTA 1689

  Fly  1980 AVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACP----AQLSLVSLVSSIRVMPMDSFVMTLHHV 2040
            |||..|.::             :.||:|.::..|    :||:||.||.::..:..|:.:..:..|
Human  1690 AVAAVWSRK-------------KAQRHSKMKIIPTASASQLTLVDLVCALSTLQTDTLLHLVKEV 1741

  Fly  2041 VRSPPPI----HRPPAQLSIEVSALELFYFYMKSAPAPQLADAWSSLLALIRDG--LNLTPPAQF 2099
            |:.||.:    .:.|.   :::..|:..|.:::..|.|.|.:.:||||.::::.  |||.||..|
Human  1742 VKRPPQVKGGDEKSPL---VDIPVLQFCYAFLQRLPVPALQENFSSLLGVLKESVQLNLAPPGYF 1803

  Fly  2100 ALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSLSSVAGSCLEQTTWLRRNLAVK------ 2158
            .||.:||:||.|.|.:  ::||:.::|.::|.::::::.::|||.||||:||.|||.||
Human  1804 LLLSMLNDFVTRTPNL--ENKKDQKDLQEITQKILEAVGNIAGSSLEQTSWLSRNLEVKAQPQAS 1866

  Fly  2159 -------EDT-DGLAKDNSVGGGGLQQYSLQAQSVLAAILSNLLDVAYGSQEKDKVVNIVTPLLY 2215
                   ||. |..|....|.......||:||.|:||.:|::|||:.|.|.||:|.|.:::.|||
Human  1867 LEESDAEEDLYDAAAASAMVSSSAPSVYSVQALSLLAEVLASLLDMVYRSDEKEKAVPLISRLLY 1931

  Fly  2216 NITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIM 2280
            .:.|||:||:|.|.|.|.|.:.||:|||||.||::||||::|:|.||.|||||..||: .|:.|:
Human  1932 YVFPYLRNHSAYNAPSFRAGAQLLSSLSGYAYTKRAWRKEVLELFLDPAFFQMDTSCV-HWKSII 1995

  Fly  2281 DSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDI 2345
            |.|:|::.|.|::||.    .|:.||.:|:|    :||:||||||.||.::..|.||::.|:|.|
Human  1996 DHLLTHEKTMFKDLMN----MQSSSLKLFSS----FEQKAMLLKRQAFAVFSGELDQYHLYLPLI 2052

  Fly  2346 QEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMSPDHVTSLWPIIIAEMVQVFLQMEQELKSESEE 2410
            ||:|.::|| |.....|.|.:||.|||||||:||.|:||||||:::|::|.|.|:|::||.|.|
Human  2053 QERLTDNLR-VGQTSIVAAQMFLFFRVLLLRISPQHLTSLWPIMVSELIQTFTQLEEDLKDEDE- 2115

  Fly  2411 RNQQLRLPSGID---VSWSAASGASNGYNSQTPMQHWRSVQLEACKLLELGCVLPATKLPHFQMY 2472
               .||..:.::   ||...|:|.|.|...|:.:    .:.|.|||.|:.....|..|:|.||:|
Human  2116 ---SLRSTNKVNRTKVSVPDANGPSVGEIPQSEL----ILYLSACKFLDTALSFPPDKMPLFQIY 2173

  Fly  2473 RWAFV------GTEF--DVHE-EEVCLPNGSLENLATLPSALYVPHVRRVARLMDMKY------- 2521
            ||||:      |..|  ||.| .:.|                 .||..|:..|:.:|:
Human  2174 RWAFIPEVDTEGPAFLSDVEENHQEC-----------------KPHTVRILELLKLKFGEISSSD 2221

  Fly  2522 ----TSQSPILQRPSNRHLMLHFQQLQSLQELYAFFTTLGISCPQPRNF-ADTE---------ND 2572
                .|:.|:|::.|          :.|:::|..||.||..:....|.. ||:.         .|
Human  2222 EITMKSEFPLLRQHS----------VSSIRQLMPFFMTLNGAFKTQRQLPADSPGTPFLDFPVTD 2276

  Fly  2573 VANCLKEIEEVLANDFLE 2590
            ....||::||.:..||||
Human  2277 SPRILKQLEECIEYDFLE 2294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15099	NP_001261081.1	Dopey_N	18..304	CDD:282036	152/294 (52%)
		Dopey_N	<2200..2477	CDD:296427	130/279 (47%)
DOP1B	NP_001307643.1	Dopey_N	13..308	CDD:282036	152/294 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..598		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..686		12/68 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..727		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1097..1139		13/50 (26%)
		Dopey_N	<1951..2107	CDD:296427	84/165 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160030
Domainoid	1	1.000	721	1.000	Domainoid score	I111
eggNOG	1	0.900	-	-		E1_COG5221
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	971	1.000	Inparanoid score	I320
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46621
OrthoDB	1	1.010	-	-		D29961at2759
OrthoFinder	1	1.000	-	-		FOG0003065
OrthoInspector	1	1.000	-	-		otm41469
orthoMCL	1	0.900	-	-		OOG6_102162
Panther	1	1.100	-	-	LDO	PTHR14042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R332
SonicParanoid	1	1.000	-	-		X2429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800