Protein Alignment CG15099 and Dop1b

DIOPT Version :9

• Sequence 1: NP_001261081.1
• Gene: CG15099 / 37176
• FlyBaseID: FBgn0034400
• Length: 2683
• Species: Drosophila melanogaster
• Sequence 2: XP_011244445.1
• Gene: Dop1b / 70028
• MGIID: 1917278
• Length: 2333
• Species: Mus musculus
• Alignment Length: 2833
• Identity: 819/2833 - (28%)
• Similarity: 1264/2833 - (44%)
• Gaps: 758/2833 - (26%)

  Fly     9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73
            |||:|:.:.:||:|.:.|:|||||||.|||||||||:||||:||:.||.:|.::||||.|:||||
Mouse     4 EEQELLNDYRYRSYSSVIEKALRNFESSSEWADLISSLGKLNKALQSNLKYSLLPRRLIISKRLA 68

  Fly    74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137
            ||:||||||||||||||||.:||...|.:.||.: |:||.||||||.||||:|||.||.:||.||
Mouse    69 QCLHPALPSGVHLKALETYEIIFKIVGTKWLAKDLFLYSCGLFPLLAYAAMSVRPVLLGLYEKYF 133

  Fly   138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202
            :||...|.|:|..||.|:|||.:.|.:.:||..|||.::...|....||..||.||..:.:||||
Mouse   134 LPLQKLLLPSLQAFLVGLLPGLEEGSEIYERTDALLLRLSVVVGREVFYAALWGSVLTSPSIRLP 198

  Fly   203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSE 267
            |..:::.|.::....:||..::|.:.::.:.:||..|.|:.:|||||.||.:|..||.:|.|..|
Mouse   199 ASLFVVNHISRDSPGKEQKCMLGTDYQLTVRSLCASLLDANVLVQRNNLEIILFFFPFYTCLDPE 263

  Fly   268 D--------DLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEP 324
            :        |:|.:::....|:|||||||||||::|||||::..|:....:   :.||: .|::.
Mouse   264 ERAIPLLRRDVVHILSAATQTLLRRDMSLNRRLYAWLLGSDIKGNTIVPKS---EISNS-YEDQC 324

  Fly   325 EPYFVKHSRHILIKALITTLRLSLECAPMD------LKPYRIMLSLLDKAEIGSAVLDYVLHDII 383
            ..:|.|:|:.:|::||...|......|.::      |||:||::|||||.|||..|::.:..::|
Mouse   325 SYFFDKYSKDLLVEALAEILHQKFLDADLEERHHAYLKPFRILVSLLDKPEIGPQVVENLFLEVI 389

  Fly   384 RAM---------------YISSGN------------AEALKSANLLFATFDPAYIWSYMTNMFEK 421
            ||.               |..|||            :|.:|:.|||.::....::|.||...||
Mouse   390 RAFYSYCHDVLGSDLKLSYTQSGNPLISTIKENRHASEIVKTVNLLVSSLSSDFLWDYMARRFE- 453

  Fly   422 ACQQANSMQEKSQAGETSGKYACDVGSGDPCVLEICVLTEFLLETVSLEMYTETTRVYLPKVFLA 486
            ||  ...:.:.:..||..        |..|.|.|:|.|..|||:.:.||:|:|....|||:|...
Mouse   454 AC--FRPVTQTTAIGEAI--------SPPPTVSELCTLLVFLLDVIPLELYSEVQTQYLPQVLGC 508

  Fly   487 ITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSSDEKITMNSASDA 551
            :.|.|:..::.:|..|:|.:||.|.|::|:||   ..|..|:  :|.|.|:||..|  ..::..|
Mouse   509 LLQPLAEEVEALSLPELTHALKTCFKVLSKVQ---MPPSYLD--LEPSSGNSSPVK--GRNSGIA 566

  Fly   552 GKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQSPNKKKAKSISRL 616
            .:|||...|                          |||                     .|...|
Mouse   567 METEAVVAG--------------------------DEE---------------------PSFPPL 584

  Fly   617 SELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQSNTSAEVSDGPS 681
            ...|..|..|.:..:.|..|..||                               .|||..|
Mouse   585 KSEDSGIGLSASSPELSEHLRVPR-------------------------------VSAERDD--- 615

  Fly   682 AEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQY---EIFFEVYLSRKLLHIESEPKECS 743
                         .::.|    .|.|..|..:::.|..:   .||   ..|..:...|::|:|..
Mouse   616 -------------IWKKD----GTMQATFLCIQELIANFASKNIF---AASLTVSGEENKPEEPP 660

  Fly   744 VKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQ-LQRLLN-RSLPL 806
            .|....:|.||.|               |.|:|..:.     :...||:.|| |..|.. |..|.
Mouse   661 GKGNKGQTQSTEH---------------PGRKSSWDP-----KPITVPQFKQMLSDLFTVRGSPF 705

  Fly   807 PASASE-LSSDSEAQEEKQQSLLIDGQTQRSVQQ-LAELQLS-PSLRGAVKLAATLLVEMSTFPN 868
            ...:|| |||...:...|       ..|:..|.| :.||..| ...|.|:..|..||::.:|||
Mouse   706 KTRSSESLSSVPSSPHRK-------AATEWGVDQVVVELVGSKEDCREALAAACHLLLDCATFP- 762

  Fly   869 CNKHVVLDKNEPE----------------LPNWLKVLCLVACFAQSDKELQVASITTLFDLISLL 917
                |.|.:.|.|                .|.|||.|..:.| ..||..||..:|.||.::|:..
Mouse   763 ----VYLSEEETEQLCETLFQTPGASDCSFPPWLKSLMTICC-CVSDCSLQNIAIATLLEVINHS 822

  Fly   918 RS---QIE-----HTTSPGVTF-----VVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTAGI 969
            :|   .||     :.||....|     :|.:|.:..|.:..:.:.|..:|.|:.:||:.|.....
Mouse   823 QSLALVIEDKMKRYKTSGNNPFFGKLQMVTVPPIAPGILKVIAEKTDFYQRVARVLWNQLNKETR 887

  Fly   970 D-PAQIAALLHQLHSCL--ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEAQ 1031
            : ......|.::|| ||  .:.:.|.:|.:                                  .
Mouse   888 EHHITCVELFYRLH-CLAPTANICEDIICH----------------------------------A 917

  Fly  1032 LLCPTESTERLRESQARSFKKFELLWHLGRDKQTA------RGFEKTLLKVLDTLALPHYMSERT 1090
            ||.|.:.|      :..:..:|.::|||.|:.|.:      |.|:::|..|||:||.........
Mouse   918 LLDPDKGT------RLEALFRFSVIWHLTREIQGSRVTSHNRSFDRSLFVVLDSLACTDGAISAA 976

  Fly  1091 FVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVYAISSEQ 1155
             ...||..:|..||:||:.:|:..:||...::|..|   |.|.:|:..|       |::...
Mouse   977 -AQGWLVRALSLGDVARILEPMLLLLLQPKTQRTSI---QCLKQENSAE-------DLHRWF--- 1027

  Fly  1156 GNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDKSTVATCSEATQDMNTIGL 1220
                         |:||                                 .||.||..:.
Mouse  1028 -------------NRKK---------------------------------PTCKEACGES----- 1041

  Fly  1221 IINPLENANDFDDETDLEEPRIEIPHKE-TPLEQKLASAMDESEQPSQEQPANQPDNSLQYDQDI 1284
              .|.|.|           |...:|..: |.::::...|..|.|.......::..:..|.|..|:
Mouse  1042 --EPQEGA-----------PEERLPRGQFTTVDREAIWAEVEKEPEKCPPRSDLSEEDLPYYVDL 1093

  Fly  1285 TDH--SDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGDCESVTDALTQHEKIKSRKT 1347
            .|.  |...|....:|..:||....||...|:.:..|.|::....: |:....:....:..|::.
Mouse  1094 PDRMTSGGGDSSEHTESADTSSGHTDSENTSTFSSPSHDLQDLSHE-ENCCAPIPIGGRAYSKRA 1157

  Fly  1348 YRLT--REKTPGENSLNSLEQKDHDSISELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSCI 1410
            ..|.  :.::|..|:..||.:.|        :|...|.|.|..|:
Mouse  1158 ALLAAFQPESPRSNARLSLVRAD--------SDKTQASESFSSDE-------------------- 1194

  Fly  1411 SKTSTDSNISGSHVEQPEQEEETEPGTESTINVEDKRRNLSLETSKLQPDMQKTLEKGKQNVEIL 1475
                                       |:.:.::      ::.||:|                 |
Mouse  1195 ---------------------------EADVELQ------AITTSRL-----------------L 1209

  Fly  1476 RQNNAAAAAAAAAAAEEQISVRSSMKSTVSLTDAAHLYHNHLLIYLAIYDTRQTLYALQTLRNII 1540
            :|..           |:|.:|.:..|              |:|:||..||:::.|||...|..::
Mouse  1210 KQQR-----------EKQETVEALFK--------------HILLYLQPYDSQRVLYAFSVLEAVL 1249

  Fly  1541 CCDKRTFLCLSITTSFSSAS------LKQLLVRHRKSISGKGFDGSVGNSEYAQGYRGC---MQL 1596
            ..:.:.|:.....|...::|      :..||.||::::.|:.|.|.:    ..|....|   :.:
Mouse  1250 KTNPKEFIEAVSRTGIDTSSTAHLNLISNLLARHQEALIGQSFYGKL----QTQAPNVCPHSLLI 1310

  Fly  1597 ELLVTLCLFYARGYFQKESLDAQRQSPTLQDIVNNRRIQLESIELLTLICSELIEIVKGMGRGLA 1661
            |||..|||.:.|.|:........|      ||:.||.:|::|:|:|..|.::|:.:.|.......
Mouse  1311 ELLTYLCLSFLRSYYPCYLKVCHR------DILGNRDVQVKSVEVLIRITAQLVSMAKSAEGKNT 1369

  Fly  1662 NYIADLLARAKLQKVMLHCLNSSVCS----YGLKGNTNSG------SYAEQVLSFNDPQDDQLHA 1716
            .:|..||.|.|:|:.:|..|::|:.:    |||......|      |..|:.| .|..||.....
Mouse  1370 EFIHSLLQRCKVQEFVLLSLSASMYTSQKRYGLATADRGGRLLAEDSLFEESL-INLGQDQIWSE 1433

  Fly  1717 DCFQLQLLRLLLAVIRLEHEVHQLRQ--DTPPAAGEDSAGNASPTRLAEGATANVKYLPNCLISQ 1779
            ...|::||:||.|:|.|||.:.|.::  :|.||...:.. .|...:.|.||...|:..|   ::.
Mouse  1434 HPLQIELLKLLQALIVLEHHLGQGQEEAETQPALSREWQ-RALNFQQAIGAMQYVQPHP---LTS 1494

  Fly  1780 QPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNIVISVVHQLCSNLDRISKM---- 1840
            |.:.::||:..||......:|..|..|||.||..|. .||...|...|.|:|.|||.:.|.
Mouse  1495 QGLLVSAVVRGLQPAYGYGMHPAWVSLVTHSLPYFG-KSLGWTVTPFVIQICKNLDDLVKQYESE 1558

  Fly  1841 -------GLPQQRHFPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSSTG 1898
                   ...::.:..|||.::.||.||.:.|:|||:...|
Mouse  1559 SVKFTISTTSKKENISPDYPLTLLEGLTTISHFCLLEQPTQ------------------------ 1599

  Fly  1899 QLLNSIVHSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIWD---SELGQLRPV-- 1958
                         .:.:.:...|.|  |:.|:||:|..||||::::|.||:   .|..|.|||
Mouse  1600 -------------HKKTAAVSDPIN--LRNAKNAILEELPRIVNTMALIWNVLRKEETQKRPVDL 1649

  Fly  1959 ------------------RQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQR 2005
                              ||::|:.|:|::.|.|...:||||..|.::             |.:|
Mouse  1650 LGATKGSSSVYFKTTKTIRQKILDLLNPLTGHLGVQLIAAVATVWNRK-------------QARR 1701

  Fly  2006 NSVLQACP----AQLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPPI------------------- 2047
            :|..:..|    :|.:||.||.::..:..||.:..:..||:.|..|
Mouse  1702 HSKTKMVPVANTSQHTLVDLVCALSTLQTDSVLQLVKEVVKRPAQIKGDEGHSAHGSSRSMYGDC 1766

  Fly  2048 --HRPPA--QLS--IEVSALELFYFYMKSAPA------------PQLADAWSSLLALIRDG--LN 2092
              |..|.  |.|  :::..|:..|.:::...|            |.|.:|:.|||.::::.  ||
Mouse  1767 SCHSRPGRDQKSPLVDIPVLQFCYAFIQRGGATKVEQEAGRLSIPDLQEAFPSLLGVLKEAAQLN 1831

  Fly  2093 LTPPAQFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSLSSVAGSCLEQTTWLRRNLAV 2157
            |.||..|.||.:||:||.|.|.:  :.||:.::|.::|.|:::::.::|||.||||:||.|||.|
Mouse  1832 LAPPGYFLLLSMLNDFVTRTPNL--ESKKDQKDLQEITQRILEAVGTIAGSSLEQTSWLSRNLEV 1894

  Fly  2158 K-------EDTD-------GLAKDNS-VGGGGLQQYSLQAQSVLAAILSNLLDVAYGSQEKDKVV 2207
            |       |::|       |.|:.:: |.......||:||.|:||.:|::|||:.|.|.||:|.|
Mouse  1895 KAQPQVSLEESDAEDDVHTGAAEASTMVSASAPSVYSVQALSLLAEVLASLLDMVYRSDEKEKAV 1959

  Fly  2208 NIVTPLLYNITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDMLDLLLDNAFFQMHLSC 2272
            .:::.|||.:.|||:||:|.|.|.|.|.:.||:|||||.||::||:|::|:|.||.|||||..||
Mouse  1960 PLISRLLYYVFPYLRNHSAYNAPSFRAGAQLLSSLSGYAYTKRAWKKEVLELFLDPAFFQMDTSC 2024

  Fly  2273 LPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAMLLKRLAFVIYCSEFDQ 2337
            : .|:.::|.|:|::.|.|::||.    .|:.||.:|:|    :||:||||||.||.::..|.||
Mouse  2025 V-HWKSVIDHLLTHEKTMFKDLMN----MQSSSLKLFSS----FEQKAMLLKRQAFAVFSGELDQ 2080

  Fly  2338 HNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMSPDHVTSLWPIIIAEMVQVFLQMEQ 2402
            ::.|:|.|||:|.::|| |.....|...:||.|||||||:||.|:||||||:::|::|.|:|:|:
Mouse  2081 YHLYLPLIQERLTDNLR-VGQTSIVAGQMFLFFRVLLLRISPQHLTSLWPIMVSELIQTFIQLEE 2144

  Fly  2403 ELKSESEERN----QQLRLPSGIDVSWSAASGASNGYNSQTPMQHWRSVQLEACKLLELGCVLPA 2463
            :||.|.|.||    .:::.|        .|.|  ||...:.......::.|.|||.|:.....|.
Mouse  2145 DLKEEDESRNSHKSNRIKAP--------VADG--NGSAGRVLSPSDLTMYLSACKFLDTALAFPP 2199

  Fly  2464 TKLPHFQMYRWAFVGTEFDV------------HEEEVCLPNGSLENLATLPSALYVPHVRRVARL 2516
            .|:|.||:|||||| .|.|.            |:|  |.                 ||..|:..|
Mouse  2200 DKMPLFQIYRWAFV-PEVDTEHPAFLSELEENHQE--CR-----------------PHTVRILEL 2244

  Fly  2517 MDMKY-----------TSQSPILQRPSNRHLMLHFQQLQSLQELYAFFTTLGIS----------- 2559
            :..:|           ..:.|:|::.|          :..:::|..|||||..:
Mouse  2245 LRSRYGEIGSSDEITRKKEFPLLRQHS----------VSCIRQLIPFFTTLNCAFKTQSQLPADV 2299

  Fly  2560 -------CPQPRNFADTENDVANCLKEIEEVLANDFLE 2590
                   ||.      |||  ...|:::||.:..||||
Mouse  2300 PGTAAPECPV------TEN--PRVLRQLEECVEQDFLE 2329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15099	NP_001261081.1	Dopey_N	18..304	CDD:282036	152/294 (52%)
		Dopey_N	<2200..2477	CDD:296427	125/280 (45%)
Dop1b	XP_011244445.1	Dopey_N	13..304	CDD:367826	151/290 (52%)
		Dopey_N	<1987..2135	CDD:383713	77/157 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850399
Domainoid	1	1.000	754	1.000	Domainoid score	I89
eggNOG	1	0.900	-	-		E1_COG5221
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1079	1.000	Inparanoid score	I247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46621
OrthoDB	1	1.010	-	-		D29961at2759
OrthoFinder	1	1.000	-	-		FOG0003065
OrthoInspector	1	1.000	-	-		otm43517
orthoMCL	1	0.900	-	-		OOG6_102162
Panther	1	1.100	-	-	LDO	PTHR14042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R332
SonicParanoid	1	1.000	-	-		X2429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800