Protein Alignment CG15099 and dop1a

DIOPT Version :9

• Sequence 1: NP_001261081.1
• Gene: CG15099 / 37176
• FlyBaseID: FBgn0034400
• Length: 2683
• Species: Drosophila melanogaster
• Sequence 2: NP_001362204.1
• Gene: dop1a / 549454
• XenbaseID: XB-GENE-1006503
• Length: 2451
• Species: Xenopus tropicalis
• Alignment Length: 2846
• Identity: 878/2846 - (30%)
• Similarity: 1356/2846 - (47%)
• Gaps: 667/2846 - (23%)

  Fly     9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73
            ||.:|::::|||.|:..:||||:||||||||||||||||||:|.:.:|.:|||:||::.|.||||
 Frog     4 EEVELLSDSKYRNYVAAVDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPRKITIGKRLA 68

  Fly    74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137
            ||:|||||.|||.||||||.:||...||:|||.: |:||:||||||..|||:|:|.||::||.|:
 Frog    69 QCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLTNAAMSVKPVLLSLYEMYY 133

  Fly   138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202
            :|||..|:|.|.|.|.|:|||.:.|.::::|.:.||::|.:||....||..||.|:..:.|:|||
 Frog   134 LPLGKTLKPGLQGLLTGILPGLEEGSEYYDRTNTLLEKVASAVEQSAFYGALWGSLLTSPAVRLP 198

  Fly   203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSE 267
            .|||:|.|.|::|.|::|:||:|.:.|:|:.|:...:.||.:||||:||:.:|..||.|....:.
 Frog   199 GITYVLSHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATR 263

  Fly   268 DDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHS 332
            .|::::::..|..:|||||||||||::||||.:  .|.......|...||.  ||....||...|
 Frog   264 PDMIRILSAALRVVLRRDMSLNRRLYAWLLGFD--NNGTAVGPRSSRQSNP--EEHATHYFNTFS 324

  Fly   333 RHILIKALITTLR---LSLECAPM-DLKPYRIMLSLLDKAEIGSAVLDYVLHDIIRAMY------ 387
            :.:|::|::..|:   :|.|.||: ||||:||::|||||.|:|.|:|:.||.::.|.:|
 Frog   325 KELLVQAMVGILQGKEMSRESAPVQDLKPFRILISLLDKPELGPAILEDVLIEVFRTLYTQCKAE 389

  Fly   388 ---------------ISS------GNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQE 431
                           :||      ..||.:|:|||||.:|:|.|:|.|:...||:.|::....:.
 Frog   390 LDLQAQTPFSKDPVQLSSKLRENKRTAELIKTANLLFNSFEPYYMWDYIARWFEECCRRTLHSRI 454

  Fly   432 KSQAGETSGKYACDVGSGDPCVLEICVLTEFLLETVSL----------EMYTETTRVYLPKVFLA 486
            ::..|::|        ..:..::..|:|.:|||:.|||          |.|.|....:||::.|.
 Frog   455 QTPGGDSS--------KPELPLINFCLLVDFLLDIVSLPTRSMRVICQEAYIEIQTEHLPQLLLR 511

  Fly   487 ITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSS-----DEK---- 542
            :...|:.|:..:...|:..||:||.||:|:|||.:.|| .::..:...||.:|     ||:
 Frog   512 MISALTSHLQALDLKELEDSLRLCSKILSKVQPPLLSP-GVDGSVHFPGGQNSYCKEKDERKLSP 575

  Fly   543 ITMNSASDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQSPNK 607
            :|..:..|.  .|.|.  |......|:|...:|.:.....||..|.|  .:.|:...:|
 Frog   576 VTSENTGDV--FEDGE--NPPSSRSSESGFTEFVQYQADRADDIDNE--GQGAAGLPLG------ 628

  Fly   608 KKAKSISRLSELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQSNT 672
                                   .:||:.:|..:|
 Frog   629 -----------------------STSSEAETVSTI------------------------------ 640

  Fly   673 SAEVSDGPSAEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSRKLLHIES 737
                    .:||....|...:||.......:.||:   :.::.|:..::.|
 Frog   641 --------GSEETLILPLCFSPQRIAARSIKPTQK---TAMQGCLEYFQQF-------------- 680

  Fly   738 EPKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQRLLNR 802
                                                    :.|||.|.   |:|:|.....::|.
 Frog   681 ----------------------------------------LTRLFTLY---IIPKSPVTMEVINV 702

  Fly   803 SLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSP-SLRGAVKLAATLLVEMSTF 866
            .....|.|......:..||..::.     :|.|        .||| ..|.|...|..|.:|.|:|
 Frog   703 GDFAGAYADSTKWQTPMQENPKEK-----KTNR--------PLSPKEYRPAFIAACQLFLECSSF 754

  Fly   867 P--------NCNKHVVL---DKNEPELPNWLKVLCLVACFAQSDKELQVASITTLFDLISLLRSQ 920
            |        ....|..:   |..:.:.|.||:.| :.||....|..:|..:|:.:.||:.|.:|.
 Frog   755 PVYIAEGSQASEIHASMANTDCEQVQPPLWLQTL-MNACNMAQDFSIQSVAISLVMDLVGLTQSV 818

  Fly   921 I----EHTTS----------PGVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTAGIDP 971
            .    |:::|          .|...||:.|.|..|::.|:.:.|..|:.|:..||:.||......
 Frog   819 AVVAGENSSSLEPSQPLSPNQGRVSVVIRPPLTEGNLRYIAEKTDFFKHVALTLWEQLGDQTPKH 883

  Fly   972 AQIAA-LLHQLHSCL-ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEAQLLC 1034
            .|.:. |.:||||.: .|.:.|.||     ||.|
 Frog   884 HQRSVELFYQLHSLVPSSSICEDVI-----SQQL------------------------------- 912

  Fly  1035 PTESTERLR-ESQARSFKKFELLWHLGRD------KQTARGFEKTLLKVLDTL-ALPHYMSERTF 1091
             |...:::| |:..|    |.:||||.||      ....|.|:::|..:||:| :|....|  :.
 Frog   913 -THKDKKIRMEAHGR----FAVLWHLTRDLHINKTSSYGRTFDRSLFIMLDSLNSLDGCTS--SV 970

  Fly  1092 VTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVYAISSEQG 1156
            ...||...|.|.|:||:.:||..:||...::||.:..:|                     :....
 Frog   971 AQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQ---------------------AERHW 1014

  Fly  1157 NVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDKSTVATCSEATQDMNTIGLI 1221
            :....::|.:         ||...:||      ..::.:|........||:...||.||.|..|.
 Frog  1015 SKSLRYLEDN---------RNNCLRIF------TSSDALSTSRESTGQVASKRGATNDMETFSLT 1064

  Fly  1222 INPLEN---------------ANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPA 1271
            :|||.:               ..|||           :|.::|.:.|...|...:|..
 Frog  1065 VNPLSDRLSLLSTSSETIPMGVCDFD-----------LPDQQTEILQSSDSGCSQSSV------- 1111

  Fly  1272 NQPDNSLQYDQDITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGDC--ESVTD 1334
                            .:|.:::.|:|    ||..:|:....:...:::.|::.:.|.  :.:||
 Frog  1112 ----------------GESVNYDVDAE----SISAQDNCQTLAEEPIAEIVQQVILDLIYKVLTD 1156

  Fly  1335 ALTQHEKIKSRKTYRLTREKTPGENSLNSL---EQKDHDSISELQADALPADEYFREDKKLGKRK 1396
            .                     ||::.:|.   .|:|...|..:......|.:  .|.:.:....
 Frog  1157 L---------------------GEDAGSSYSQDNQQDTPHIINMPNSTASARD--NEGEVVQLND 1198

  Fly  1397 KVLTSGEKKRLSCIS-KTSTDS--NISGSHVEQPEQEEETEPGTESTINVED---KRRNLSLETS 1455
            .||.:.:..||..:| :...:|  |....::..|....:..| ||..:|:|.   ||.:.|::.:
 Frog  1199 DVLVANDPSRLLSVSAEVGIESLANAISRNISSPCIMGQQNP-TEFNLNLESQSRKRSHSSIQFN 1262

  Fly  1456 ----------------------KLQPDMQKTLEKGKQNVEILRQNNAAAAAAA-----AAAAEEQ 1493
                                  ||:...:|..:|.|...|.|:|.|...:...     .:..|.:
 Frog  1263 FIGKATEKDSSAKDVSKQGAKPKLKMSRRKDEDKKKTQNEKLKQANVFFSDGLDLENWYSCGEGE 1327

  Fly  1494 IS----------VRSSMKSTVSLTDAAHLYHNHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFL 1548
            ||          ||.|....:      |..:.|:|:||.:||:.:|||||..::.|:......|:
 Frog  1328 ISEIESDVGSPGVRKSPHFNI------HPLYQHVLLYLQLYDSSRTLYALTAIKAILKTSPTVFV 1386

  Fly  1549 CLSITTSFSSA------SLKQLLVRHRKSISGKGFDGSVG-NSEYAQGYRGCMQLELLVTLCLFY 1606
            ....||:.|:|      .|:.||.|||.|:.||.|..::. :|.:  .:|..|.:|:|::|||::
 Frog  1387 KAISTTNVSNAYTPQLSLLQNLLARHRISVMGKDFYSNIPLDSNH--NFRSSMYIEILISLCLYF 1449

  Fly  1607 ARGYFQKESLDAQRQSPTLQDIVNNRRIQLESIELLTLICSELIEIVKGMGRGLANYIADLLARA 1671
            .|.::      ......|.||::.||.:|:.|||:|||:.:||.::::...:|.|::|:|:|::.
 Frog  1450 MRSHY------PTHVKVTQQDLMGNRNMQMMSIEILTLLFTELAKVIESSAKGFASFISDMLSKC 1508

  Fly  1672 KLQKVMLHCLNSSVCSYGLKGNT-----------NSGSYAEQVLSFNDPQDDQLHADCFQLQLLR 1725
            |:|||:||||.||:.| ..|.::           ..|...:.:::|::.:.|  :....|.|||:
 Frog  1509 KVQKVILHCLLSSIFS-AQKWHSERMAEKNIMAIEEGFSEDSLINFSEDEFD--NGSTLQSQLLK 1570

  Fly  1726 LLLAVIRLEHEVHQLRQDTPPAAGED----SAGNASPTRLAEGATANVKYLPNCLISQQPMFLAA 1786
            :|.::|.|||.|..:.:|.  .||.|    ...|.:|    :....:::||.:..|:.|.|||.|
 Frog  1571 VLQSLIILEHRVLTVPEDN--EAGFDFVITDLENINP----QQPMTSLQYLHSQPITCQGMFLCA 1629

  Fly  1787 VLGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNIVISVVHQLCSNLDRISKM-----GLPQQR 1846
            |:.||.|.....:|..|..|:||:|. :....|..:|:||..|||.|||.:.:.     |:...|
 Frog  1630 VIRALHQHYTCKMHPQWICLMTSTLP-YMGKVLQKVVVSVTLQLCRNLDNLIQQYKYETGITDSR 1693

  Fly  1847 ------HFPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSSTGQLLNSIV 1905
                  ..|||.:::.||.:|.:.||||||.:.|          |.|...|....
 Frog  1694 PLWMASFIPPDMILTVLEGITTIIHYCLLDPSAQ----------YHQLMVSVDQK---------- 1738

  Fly  1906 HSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIW------DS-------------- 1950
                               .|..||:.:||.|..|||||..:|      ||
 Frog  1739 -------------------HLLEARSGMLSILHLIMSSVTLLWSVLHQADSSEKNFTAASATVTT 1784

  Fly  1951 -ELGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVL-QACP 2013
             .||..:.:|||:||.|.|:|::||..|:||:|..|.:|  ..|.|.       .|..|: .|..
 Frog  1785 VNLGSTKNLRQQILELLGPISMNHGVYFMAAIAFVWNER--RQNKNS-------TRTKVIPSASD 1840

  Fly  2014 AQLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPPIHRPPAQLSIEVSALELFYFYMKSAPAPQLAD 2078
            .||.||.||.||.||..::.:.|:..|::.||.|.:....||:||..|:.||.|::..|...|.|
 Frog  1841 EQLLLVELVRSISVMRTETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYVQRIPVSNLVD 1905

  Fly  2079 AWSSLLALIRDG--LNLTPPAQFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSLSSVA 2141
            :|:|.|.|::|.  ||:..|.||.:|.:||||:.:.|.:  ::||:.|:|.|||.::||::.::|
 Frog  1906 SWASFLVLLKDSIQLNIPAPGQFLILGVLNEFIMKNPTL--ENKKDQRDLQDVTHKIVDAIGAIA 1968

  Fly  2142 GSCLEQTTWLRRNLAVKED----TDGLAKDNSVGGGGLQQ-----------YSLQAQSVLAAILS 2191
            ||.|||||||||||.||..    .||...::.|....|..           ||:.|.::||.:|:
 Frog  1969 GSSLEQTTWLRRNLEVKPSPRITVDGTNLESDVEDIMLSPVMEISNITPSVYSVHALTLLAEVLA 2033

  Fly  2192 NLLDVAYGSQEKDKVVNIVTPLLYNITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDM 2256
            :|||:.:.|.||::|:.::..:::.:.|||:||:|.|...:.||..||:|||||||||:.|:|:.
 Frog  2034 HLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNASSYRACVQLLSSLSGYQYTRRTWKKEA 2098

  Fly  2257 LDLLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAM 2321
            .||.:|..||||..||:..||.|||.|||:|.||||:|||||:::|:.||.:||:||.|.|||||
 Frog  2099 FDLFMDPNFFQMDGSCVSHWRSIMDHLMTHDKTTFRDLMTRVAVAQSSSLGLFTNRDAELEQRAM 2163

  Fly  2322 LLKRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMSPDHVTSLW 2386
            |||||||.|:.||.||:.|::|||||:|..|||| |..|::.:.|||.||||||||||.|:||||
 Frog  2164 LLKRLAFAIFSSEIDQYQKFLPDIQERLVESLRL-PQVPTLHSQVFLFFRVLLLRMSPQHLTSLW 2227

  Fly  2387 PIIIAEMVQVFLQMEQELKSESEERNQQLRLPS--GIDVSWSAASGASNGYNSQTPMQHWRSVQL 2449
            |.:|.|:|||||.|||||  .::|...::..||  |::.:::..:|.|..|||    |.|.::.|
 Frog  2228 PTMITELVQVFLLMEQEL--TADEDITRISGPSVAGLETTYTGGNGFSTSYNS----QRWLNLYL 2286

  Fly  2450 EACKLLELGCVLPATKLPHFQMYRWAFVGTEFD----------VHEEEVCLPNGSLENLATLPSA 2504
            .|||.|:|...||:..||.||||||||:....|          .|:.|
 Frog  2287 SACKFLDLALALPSENLPQFQMYRWAFIPEASDDAGLEVRRQGTHQRE----------------- 2334

  Fly  2505 LYVPHVRRVARLMDMKYTSQSP--------ILQRPSNRHLMLHFQQLQSLQELYAFFTTLG---- 2557
             :.|:|.|:|:|: .|...::|        :...|.|  |:|....::::::|..||..|.
 Frog  2335 -FKPYVVRLAKLL-RKRAKKNPEEDCSGRTLDWNPGN--LLLTIYSIRTIEQLLPFFNVLSQVFN 2395

  Fly  2558 ----------------ISCPQPRNFADTENDVANC--LKEIEEVLANDFLE 2590
                            .....|......||....|  .::|||:|..||||
 Frog  2396 SKITSRCVGESGSPILYQSSFPNKDIKMENQKLFCKIRQKIEEMLERDFLE 2446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15099	NP_001261081.1	Dopey_N	18..304	CDD:282036	152/286 (53%)
		Dopey_N	<2200..2477	CDD:296427	150/278 (54%)
dop1a	NP_001362204.1	Dopey_N	13..297	CDD:367826	152/285 (53%)
		Dopey_N	<2078..2314	CDD:383713	137/242 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	824	1.000	Domainoid score	I67
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1150	1.000	Inparanoid score	I211
OMA	1	1.010	-	-		QHG46621
OrthoDB	1	1.010	-	-		D29961at2759
OrthoFinder	1	1.000	-	-		FOG0003065
OrthoInspector	1	1.000	-	-		oto104022
Panther	1	1.100	-	-	O	PTHR14042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R332
SonicParanoid	1	1.000	-	-		X2429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110