Protein Alignment CG15099 and Dop1a

DIOPT Version :9

• Sequence 1: NP_001261081.1
• Gene: CG15099 / 37176
• FlyBaseID: FBgn0034400
• Length: 2683
• Species: Drosophila melanogaster
• Sequence 2: XP_006511298.1
• Gene: Dop1a / 320615
• MGIID: 1289294
• Length: 2480
• Species: Mus musculus
• Alignment Length: 2843
• Identity: 887/2843 - (31%)
• Similarity: 1388/2843 - (48%)
• Gaps: 632/2843 - (22%)

  Fly     9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73
            ||.:|::::|||.|:..|||||:||||||||||||||||||:|.:.:|.:|||:|::|.|.||||
Mouse     4 EELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKKLTIGKRLA 68

  Fly    74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137
            ||:|||||.|||.||||||.:||...||:|||.: |:||:||||||..|||:|:||||.:||.|:
Mouse    69 QCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMSVKPALLGLYEMYY 133

  Fly   138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202
            :|||..|:|.|.|.|.|:|||.:.|.:::||.:.||::|..||....||:.||.|:..:.|:|||
Mouse   134 LPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNTLLEKVAAAVEQSAFYSALWGSLLTSPAVRLP 198

  Fly   203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSE 267
            .|||:|.|.|::|.|::|:||:|.:.|:|:.|:...:.||.:||||:||:.:|..||.|....:.
Mouse   199 GITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATR 263

  Fly   268 DDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHS 332
            .|::::::..|:.:|||||||||||::||||.:  .|.......|...||.  ||....||...|
Mouse   264 PDMIRILSAALHVVLRRDMSLNRRLYAWLLGFD--NNGAIIGPRSTRHSNP--EEHATYYFTTFS 324

  Fly   333 RHILIKALITTLRLS---LECAPM-DLKPYRIMLSLLDKAEIGSAVLDYVLHDIIRAMY------ 387
            :.:|::|::..|:::   .|...| ||||:||::|||||.|:|..:|:.||.::.|.:|
Mouse   325 KELLVQAMVGILQVNGFGEESTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAE 389

  Fly   388 ---------------ISS------GNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQE 431
                           :||      ..||.:|:|||||.:|:|.|:|.|:...||:.|::  ::..
Mouse   390 LDLQMEPPFSKDHAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYIARWFEECCRR--TLHA 452

  Fly   432 KSQAGETSGKYACDVGSGDPCVLEI---CVLTEFLLETVSL----------EMYTETTRVYLPKV 483
            :.|.|...        |.|...|::   |:|.:|||:.|||          |.|.|....:||::
Mouse   453 RLQVGPGD--------SSDSSELQLTNFCLLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHLPQL 509

  Fly   484 FLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSS----DEKIT 544
            .|.:...|:.|:..:..:|:|.||:||.||:|:|||.:.|......:...||.:|:    ::|..
Mouse   510 LLRMISALTSHLQTLRLSELTDSLRLCSKILSKVQPPLLSAGNGGVVQFPSGQNSTVKEWEDKKQ 574

  Fly   545 MNSASDAGKTEAGAQGNSLEKSK-SDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQSPNKK 608
            ::|.|.....|....|.:...|: |:|...:|.:......|..|.||..:.|:...:|
Mouse   575 VSSVSMENPAEVFEDGENPPSSRSSESGFTEFIQYQADRPDDLDRELNGQGAATIPIG------- 632

  Fly   609 KAKSISRLSELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQSNTS 673
                                  .:||:.:|..::
Mouse   633 ----------------------STSSETETASTV------------------------------- 644

  Fly   674 AEVSDGPSAEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSRKLLHIESE 738
                   .:||....||....|.......:|.|:   :.::.|:...:.|....::..::|.:|.
Mouse   645 -------GSEETVIQPPSTFTQGAAGRSGKAVQK---TAMQCCLEYVQQFLSRLINLYIIHSDSF 699

  Fly   739 PKECSVKVQ-----LQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQR 798
            |:..:...|     :||.||...                 |:||.:             :|:
Mouse   700 PQALAADHQGDFSRIQRETSKWD-----------------RDSQGD-------------AKE--- 731

  Fly   799 LLNRSLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLVEM 863
               |::..|.::.|..|                                    |...|..|.:|.
Mouse   732 ---RNIHTPKTSKEYLS------------------------------------AFLAACQLFLEC 757

  Fly   864 STFP------NCNKHVVLDKNEPEL-----PNWLKVLCLVACFAQSDKELQVASITTLFDLISLL 917
            |:||      |.......:|.:.:.     |.||:.| :.||....|..:|.|:::.:.||:.|.
Mouse   758 SSFPVYIAEGNHTSESHSEKPDTDCEHAHPPQWLRTL-MSACSQARDFRVQSAAVSLVMDLVGLT 821

  Fly   918 RS------------QIEHTTSP--GVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTAG 968
            :|            :.....||  |...||:.|.|..|::.|:.:.|..|:.|:..|||.||...
Mouse   822 QSVAMVTGENINSMEPAQPLSPNQGRVAVVIRPPLTQGNLKYIAEKTEFFKHVALTLWDQLGDGT 886

  Fly   969 IDPAQIAA-LLHQLHSCL-ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEAQ 1031
            ....|.:. |.:|||:.: .|.:.|.|:     ||.|
Mouse   887 PQHHQKSVELFYQLHNLVPSSSICEDVV-----SQQL---------------------------- 918

  Fly  1032 LLCPTESTERLR-ESQARSFKKFELLWHLGRD-----KQTARGFEKTLLKVLDTL-ALPHYMSER 1089
                |...:::| |:.|    ||.:||||.||     ...||.|:::|..:||:| :|..  |..
Mouse   919 ----THKDKKIRMEAHA----KFAVLWHLTRDLHINKSSFARSFDRSLFIMLDSLTSLDG--STS 973

  Fly  1090 TFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVYAISS- 1153
            :....||...|.|.|:||:.:||..:||...::||.:..:|.....|:|...|..|.|.:.:.:
Mouse   974 SVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWSKTSCYPGEENDKHFMQNF 1038

  Fly  1154 EQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDK-STVATCSEATQDMNT 1217
            ...||...|:..|.||.:| |:.....:.|.:|:         |.:||: |.::|.||      |
Mouse  1039 TCNNVSQVHLIASKGNGEK-PLTMDEMENFSLTV---------NPLSDRLSLLSTSSE------T 1087

  Fly  1218 IGLIINPLENANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPANQPDNSLQYDQ 1282
            |.:::      :|||           :|.::..:.|...|...:|         :..|| ..|:.
Mouse  1088 IPMVV------SDFD-----------LPDQQMEILQSSDSGCSQS---------SAGDN-FSYEV 1125

  Fly  1283 DITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGDCESVTDALTQHEKIKSRKT 1347
            |    .::::...||.:.:.|...:|...|     |.|.:.:.|...|:.::::|...:|:|.:|
Mouse  1126 D----PENANAHEDSHMAKASSPDDDVQQV-----VFDLICKVVSGLEAESESVTSELEIESLQT 1181

  Fly  1348 YRLTREKTPGENSLNSLEQKDHDSISELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSC--- 1409
              .:.:..||:.:....:|....|...|.:|..|               :.|:...::...|
Mouse  1182 --KSSDLDPGKEATKIEDQAPQHSQHVLLSDDSP---------------RFLSVSTEEGCECLAN 1229

  Fly  1410 -ISKTSTDSNISGS----HVEQPEQEEETEPGTESTINVEDKRRNLSLETSKLQPDMQKTLEKGK 1469
             ||:.|:...|||:    :......|.::...:.|:|....|.: ||.:.|:.:..::   |.||
Mouse  1230 GISRNSSSPCISGTAQTLNDSSVPSETKSRQRSHSSIQFSFKEK-LSEKVSEKETIVK---ESGK 1290

  Fly  1470 Q-----NVEILRQNNAAAAAAAA--------------------AAAEEQIS-VRSSMKSTVSLTD 1508
            |     .|::.|:.:.....||:                    :..|.:|| :.|.|.|..|...
Mouse  1291 QPGAKPKVKLARKKDEDKKKAASEKLKQANVFFSEGLDLENWYSCGEGEISEIESDMGSPGSRKS 1355

  Fly  1509 A---AHLYHNHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFLCLSITTSFSSA------SLKQL 1564
            .   .|..:.|:|:||.:||:.:||||...:::|:..:...|:....|||.::|      .|:.|
Mouse  1356 PNFNIHPLYQHVLLYLQLYDSSRTLYAFSAIKSILKTNPIAFVNAISTTSVNNAYTPQLSLLQNL 1420

  Fly  1565 LVRHRKSISGKGFDGSVG-NSEYAQGYRGCMQLELLVTLCLFYARGYFQKESLDAQRQSPTLQDI 1628
            |.|||.|:.||.|...:. :|.:  .:|..|.:|:|::|||:|.|.::      ......|.||:
Mouse  1421 LARHRISVMGKDFYSHIPVDSNH--NFRSSMYIEILISLCLYYMRSHY------PTHVKVTTQDL 1477

  Fly  1629 VNNRRIQLESIELLTLICSELIEIVKGMGRGLANYIADLLARAKLQKVMLHCLNSSVCSY----- 1688
            :.||.:|:.|||:|||:.:||.::::...:|..::|:|:|::.|:|||:||||.||:.|.
Mouse  1478 IGNRNMQMMSIEILTLLFTELAKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSVQKWHS 1542

  Fly  1689 -GLKGNT----NSGSYAEQVLSFNDPQDDQLHADCFQLQLLRLLLAVIRLEHEVHQLRQDTPPAA 1748
             ...|.:    ..|...:.:::|::.:.|  :....|.||||:|..:|.|||.|..:.::.  .|
Mouse  1543 EKTAGKSMVAVEEGFSEDSLINFSEDELD--NGSTLQSQLLRVLQRLIVLEHHVMTIPEEN--EA 1603

  Fly  1749 GED----SAGNASPTRLAEGATANVKYLPNCLISQQPMFLAAVLGALQQERLRHLHRNWTDLVTS 1809
            |.|    ...:.||.:    ...:::||....|:.|.|||.||:.||.|.....:|..|..|:||
Mouse  1604 GFDFVVSDLEHISPHQ----PMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITS 1664

  Fly  1810 SLNCFSFGSLTNIVISVVHQLCSNLDRISKM-----GLPQQRH------FPPDYVVSQLEALTIL 1863
            :|. :....|..:|:||..|||.|||.:.:.     ||...|.      .|||.:::.||.:|.:
Mouse  1665 TLP-YMGKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDSRPLWVASIIPPDMILTLLEGITAI 1728

  Fly  1864 CHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSSTGQLLNSIVHSFLSASESSTSAPAPRNPQLQA 1928
            .||||||.|.|   .|                   |||.::                 ....|..
Mouse  1729 IHYCLLDPTTQ---YH-------------------QLLVNV-----------------DQKHLVE 1754

  Fly  1929 ARNAVLSHLPRIMSSVAAIWD-------SE--------------LGQLRPVRQQLLEFLSPVSLH 1972
            ||:.:||.|..|||||..:|.       ||              ||..:.:|||:||.|.|:|::
Mouse  1755 ARSGILSILHMIMSSVTLLWSILHQADASEKMAVAASASVTTINLGATKNLRQQILELLGPISMN 1819

  Fly  1973 HGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACPA----QLSLVSLVSSIRVMPMDSF 2033
            ||.:|:||:|..|.:|            .|.:..|..:..||    ||.||.||.||.||..::.
Mouse  1820 HGVHFMAAIAFVWNER------------RQNKTPSRTKVIPAASEEQLLLVELVRSISVMRAETV 1872

  Fly  2034 VMTLHHVVRSPPPIHRPPAQLSIEVSALELFYFYMKSAPAPQLADAWSSLLALIRDGLNLTPPA- 2097
            :.|:..|::.||.|.:....||:||..|:.||.|::..|.|.:.|:|:|||.|::|.:.|:.||
Mouse  1873 IQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNIVDSWTSLLVLLKDSIQLSLPAP 1937

  Fly  2098 -QFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSLSSVAGSCLEQTTWLRRNLAVKEDT 2161
             ||.:|.:||||:.:.|.:  ::||:.|:|.|||.::||::.::|||.|||||||||||.||...
Mouse  1938 GQFLILGVLNEFIMKNPSL--ENKKDQRDLQDVTHKIVDAIGAIAGSSLEQTTWLRRNLEVKPSP 2000

  Fly  2162 DGLAKDNSVGGGGLQQ-------------------YSLQAQSVLAAILSNLLDVAYGSQEKDKVV 2207
            ..:     |.|..|:.                   ||:.|.::|:.:|::|||:.:.|.||::|:
Mouse  2001 KIM-----VDGTNLESDVEDMLSPAMETSNITPSVYSVHALTLLSEVLAHLLDMVFYSDEKERVI 2060

  Fly  2208 NIVTPLLYNITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDMLDLLLDNAFFQMHLSC 2272
            .::..:::.:.|||:||:|.|.|.:.||..||:|||||||||:||:|:..||.:|.:||||..||
Mouse  2061 PLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASC 2125

  Fly  2273 LPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAMLLKRLAFVIYCSEFDQ 2337
            :..||.|||:|||:|.||||:|||||:::|:.|||:|.:||.|.||||||||||||.:..||.||
Mouse  2126 VSHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSSLNLFANRDVELEQRAMLLKRLAFAVLSSESDQ 2190

  Fly  2338 HNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMSPDHVTSLWPIIIAEMVQVFLQMEQ 2402
            :.||:|||||:|..|||| |..|::.:.|||.||||||||||.|:|||||.:|.|:|||||.|||
Mouse  2191 YQKYLPDIQERLVESLRL-PQVPTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQ 2254

  Fly  2403 ELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQTPMQHWRSVQLEACKLLELGCVLPATKLP 2467
            ||.::.:.........:|::.:::..:|.|..|||    |.|.::.|.|||.|:|...||:..||
Mouse  2255 ELTADEDISRTSGPSAAGLETTYTGGNGFSTSYNS----QRWLNLYLSACKFLDLALALPSENLP 2315

  Fly  2468 HFQMYRWAFVGTEFD----------VHEEEVCLPNGSLENLATLPSALYVPHVRRVARLM----- 2517
            .||||||||:....|          :|:.|                  :.|:|.|:|:|:
Mouse  2316 QFQMYRWAFIPEASDDSGLEVRRQGIHQRE------------------FKPYVVRLAKLLRKRAK 2362

  Fly  2518 ---DMKYTSQSPILQRPSN--------------RHLMLHFQQLQSLQELYAFFTTL--------- 2556
               |.|......:.:...|              .||:|....::::::|..||..|
Mouse  2363 DEEDFKILEGLEMAKHQKNPEEDCSGRTLGWEPGHLLLTLCTMRNMEQLLPFFNVLSQVFNSKVT 2427

  Fly  2557 -------GISCPQPRNFADTENDVAN-------CLKEIEEVLANDFLE 2590
                   |.....|.:|.:.:..:.|       ..::|||::..||||
Mouse  2428 SRCGGHSGSPVLYPNSFPNKDMKLENHKAFSSKARQKIEEMIEKDFLE 2475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15099	NP_001261081.1	Dopey_N	18..304	CDD:282036	155/286 (54%)
		Dopey_N	<2200..2477	CDD:296427	149/276 (54%)
Dop1a	XP_006511298.1	Dopey_N	13..297	CDD:367826	155/285 (54%)
		Dopey_N	<2089..2325	CDD:383713	135/240 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850398
Domainoid	1	1.000	754	1.000	Domainoid score	I89
eggNOG	1	0.900	-	-		E1_COG5221
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26645
Inparanoid	1	1.050	1079	1.000	Inparanoid score	I247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46621
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003065
OrthoInspector	1	1.000	-	-		otm43517
orthoMCL	1	0.900	-	-		OOG6_102162
Panther	1	1.100	-	-	O	PTHR14042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R332
SonicParanoid	1	1.000	-	-		X2429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790