|
Fly 9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73
||.:|::::|||.|:..|||||:||||||||||||||||||:|.:.:|.:|||:|::|.|.||||
Rat 4 EELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKKLTIGKRLA 68
Fly 74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137
||:|||||.|||.||||||.:||...||:|||.: |:||:||||||..|||:|:|.||::||.|:
Rat 69 QCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMSVKPTLLSLYEIYY 133
Fly 138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202
:|||..|:|.|.|.|.|:|||.:.|.:::||.:.||::|..||....||:.||.|:..:.|:|||
Rat 134 LPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNTLLEKVAAAVEQSAFYSALWGSLLTSPAVRLP 198
Fly 203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSE 267
.|||:|.|.|::|.|::|:||:|.:.|:|:.|:...:.||.:||||:||:.:|..||.|....:.
Rat 199 GITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATR 263
Fly 268 DDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHS 332
.|::::::..|:.:|||||||||||::||||.: .|.......|...||. ||....||...|
Rat 264 PDMIRILSAALHVVLRRDMSLNRRLYAWLLGFD--NNGAIIGPRSTRHSNP--EEHATYYFTTFS 324
Fly 333 RHILIKALITTLRLS---LECAPM-DLKPYRIMLSLLDKAEIGSAVLDYVLHDIIRAMY------ 387
:.:|::|::..|::: .|...| ||||:||::|||||.|:|..:|:.||.::.|.:|
Rat 325 KELLVQAMVGILQVNGFGEESTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAE 389
Fly 388 ---------------ISS------GNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQE 431
:|| ..||.:|:|||||.:|:|.|:|.|:...||:.|::....:
Rat 390 LDLQMEPPFSKDRAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYIARWFEECCRRTLHAR- 453
Fly 432 KSQAGETSGKYACDVGSGDPC------VLEICVLTEFLLETVSL----------EMYTETTRVYL 480
.:||.||.. :...|.|.:|||:.||| |.|.|....:|
Rat 454 ------------LEVGPGDSSDASEFQLTTFCSLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHL 506
Fly 481 PKVFLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSS------ 539
|::.|.:...|:.|:..:..:|:|.||:||.||:|:|||.:.| .....:::...|.:|
Rat 507 PQLLLRMISALTSHLQTLRLSELTDSLRLCSKILSKVQPPLLS-AGTGGVVQFPSGQNSAVKEWE 570
Fly 540 DEKITMNSASDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQS 604
|:|: :|.|....||....|.:...|:|.. :.|.|...:.|:
Rat 571 DKKV--SSVSMENPTEVFEDGENPPSSRSSE--SGFTEFIQYQAE-------------------- 611
Fly 605 PNKKKAKSISRLSELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQ 669
|..:||::::...| |.:|.
Rat 612 ----------RTDDLDRELNGQGT--------------------ATIPI---------------- 630
Fly 670 SNTSAEVSDGPS--AEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSRKL 732
.:||:|.....: :||....||....|.......:|.|: :.::.|:...:.|....:...:
Rat 631 GSTSSETETASTVGSEETVIQPPSTLTQGAAGRTGKAVQK---TAMQCCLEYVQQFLSRLIHLYI 692
Fly 733 LHIESEPKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQ 797
||.:|.| :.::..|.|:| |:|:|
Rat 693 LHSDSFP----------QASAADHQSDL---------------SRIQR----------------- 715
Fly 798 RLLNRSLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLVE 862
..|:...||:. :.|:::: .|.:: |.....|...|..|.:|
Rat 716 -----------DTSKWDRDSQG-DAKERNI----HTPKT---------SKEYLSAFLAACQLFLE 755
Fly 863 MSTFP------NCNKHVVLDKNEPEL-----PNWLKVLCLVACFAQSDKELQVASITTLFDLISL 916
.|:|| |.......:|.:.:. |.||:.| :.||...||..:|..:::.:.||:.|
Rat 756 CSSFPVYIAEGNHTSESHSEKPDTDCEHAHPPQWLQTL-MSACSQASDFSVQSVAVSLVMDLVGL 819
Fly 917 LRS------------QIEHTTSP--GVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTA 967
.:| :.....|| |...||:.|.|..|::.|:.:.|..|:.|:..|||.||..
Rat 820 TQSVAMVTGENINSMEPAQPLSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDG 884
Fly 968 GIDPAQIAA-LLHQLHSCL-ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEA 1030
.....|.:. |.:|||:.: .|.:.|.|: ||.|
Rat 885 TPQHHQKSVELFYQLHNLVPSSSICEDVV-----SQQL--------------------------- 917
Fly 1031 QLLCPTESTERLR-ESQARSFKKFELLWHLGRD-----KQTARGFEKTLLKVLDTL-ALPHYMSE 1088
|...:::| |:.|| |.:||||.|| ...||.|:::|..:||:| :|.. |.
Rat 918 -----THKDKKVRMEAHAR----FAVLWHLTRDLHVNKSSFARSFDRSLFIMLDSLTSLDG--ST 971
Fly 1089 RTFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVYAISS 1153
.:....||...|.|.|:||:.:||..:||...::||.:..:|.....|:|...|..|.|.:.:.:
Rat 972 SSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWSKTSCYPGEENDKHFMQN 1036
Fly 1154 -EQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDK-STVATCSEATQDMN 1216
...||...|:..|.|:::| |:.....:.|.:|: |.:||: |.::|.||
Rat 1037 FTCNNVSQVHLIASKGSREK-PLTMDEIENFSLTV---------NPLSDRLSLLSTSSE------ 1085
Fly 1217 TIGLIINPLENANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPANQPDNSLQYD 1281
||.::: :||| :|.::..:.|...|...:|..
Rat 1086 TIPMVV------SDFD-----------LPDQQMEILQSSDSGCSQSSA----------------- 1116
Fly 1282 QDITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGD--CESVTDALTQHEKIKS 1344
.|:..:|.|.| ..|..::..:..:||. .|||::.|.| |:.|
Rat 1117 ------GDNFSYEVDPE--NVSAHEDSHLAKASSP--DDDVQQVVFDLICKVV------------ 1159
Fly 1345 RKTYRLTREKTPGENSLNSLEQKDHDSISELQADALPADEYFREDKKLGKR------------KK 1397
:.||.:.....|||:.::||... .|..|||. :.
Rat 1160 -----------------SGLEAESASVTSELEIESLPPKS---SDFDLGKEATKTEDQAPQHSQH 1204
Fly 1398 VLTSGEKKRL---------SC----ISKTSTDSNISGSHVEQPEQEEETEPGTESTINVEDKRRN 1449
||.|.:..|. .| ||:.|:...|||: .:..|:|:::.|.|.|.
Rat 1205 VLLSDDSPRFLSVSTEEGCECLANGISRNSSSPCISGT----------AQTLTDSSVSSETKSRQ 1259
Fly 1450 LSLETSKLQPDMQKTL------------EKGKQ-----NVEILRQNNAAAAAAAA---------- 1487
.| .|.:|...::.| |.||| .|::.|:.:.....||:
Rat 1260 RS--HSSIQFSFKEKLSEKISEKETIVKESGKQPGAKPKVKLARKKDEDKKKAASEKLKQTNVFF 1322
Fly 1488 ----------AAAEEQIS-VRSSMKSTVSLTDA---AHLYHNHLLIYLAIYDTRQTLYALQTLRN 1538
:..|.:|| :.|.|.|..|.... .|..:.|:|:||.:||:.:||||...:::
Rat 1323 SDGLDLENWYSCGEGEISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSRTLYAFSAIKS 1387
Fly 1539 IICCDKRTFLCLSITTSFSSA------SLKQLLVRHRKSISGKGFDGSVG-NSEYAQGYRGCMQL 1596
|:..:...|:....|||.::| .|:.||.|||.|:.||.|...:. :|.: .:|..|.:
Rat 1388 ILKSNPVAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIPVDSNH--NFRSSMYI 1450
Fly 1597 ELLVTLCLFYARGYFQKESLDAQRQSPTLQDIVNNRRIQLESIELLTLICSELIEIVKGMGRGLA 1661
|:|::|||:|.|.:: ......|.||::.||.:|:.|||:|||:.:||.::::...:|..
Rat 1451 EILISLCLYYMRSHY------PTHVKVTTQDLIGNRNMQMMSIEILTLLFTELAKVIESSAKGFP 1509
Fly 1662 NYIADLLARAKLQKVMLHCLNSSVCSY------GLKGN----TNSGSYAEQVLSFNDPQDDQLHA 1716
::|:|:|::.|:|||:||||.||:.|. ...|. ...|...:.:::|::.:.| :.
Rat 1510 SFISDMLSKCKVQKVILHCLLSSIFSVQKWHSEKTAGKNMVAVEEGFSEDSLINFSEDEFD--NG 1572
Fly 1717 DCFQLQLLRLLLAVIRLEHEVHQLRQDTPPAAGED----SAGNASPTRLAEGATANVKYLPNCLI 1777
...|.||||:|..:|.|||.|..:.::: .||.| ...:.||.: ...:::||....|
Rat 1573 STLQSQLLRVLQRLIVLEHRVMTIPEES--EAGFDFVVSDLEHVSPHQ----PMTSLQYLHAQPI 1631
Fly 1778 SQQPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNIVISVVHQLCSNLDRISKM-- 1840
:.|.|||.||:.||.|.....:|..|..|:||:|. :....|..:|:||..|||.|||.:.:.
Rat 1632 TCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLP-YMGKVLQRVVVSVTLQLCRNLDNLIQQYK 1695
Fly 1841 ---GLPQQRH------FPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSS 1896
||...|. .|||.:::.||.:|.:.||||||.|.| .|
Rat 1696 YETGLSDSRPLWVASIIPPDMILTLLEGITAIIHYCLLDPTTQ---YH----------------- 1740
Fly 1897 TGQLLNSIVHSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIWD-------SE--- 1951
|||.:: ....|..||:.:||.|..|||||..:|. ||
Rat 1741 --QLLVNV-----------------DQKHLVEARSGILSILHMIMSSVTLLWSILHQADASEKMG 1786
Fly 1952 -----------LGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQR 2005
||..:.:|||:||.|.|:|::||.:|:||:|..| ||....:...|
Rat 1787 LAASASVTTINLGATKNLRQQILELLGPISMNHGVHFMAAIAFVW---------NGRRQNKTPSR 1842
Fly 2006 NSVLQAC-PAQLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPPIHRPPAQLSIEVSALELFYFYMK 2069
..|:.|. ..||.||.||.||.||..::.:.|:..|::.||.|.:....||:||..|:.||.|::
Rat 1843 TKVIPAASEEQLLLVELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQ 1907
Fly 2070 SAPAPQLADAWSSLLALIRDGLNLTPPA--QFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSR 2132
..|.|.|.|:|:|||.|::|.:.|:.|| ||.:|.:||||:.:.|.: ::||:.|:|.|||.:
Rat 1908 RIPVPNLVDSWASLLVLLKDSIQLSLPAPGQFLILGVLNEFIMKNPSL--ENKKDQRDLQDVTHK 1970
Fly 2133 LVDSLSSVAGSCLEQTTWLRRNLAVKEDTDGLAKDNSVGGGGLQQ-------------------Y 2178
:||::.::|||.|||||||||||.||.....: |.|..|:. |
Rat 1971 IVDAIGAIAGSSLEQTTWLRRNLEVKPSPKIM-----VDGTNLESDVEDMLSPAMETSNITPSVY 2030
Fly 2179 SLQAQSVLAAILSNLLDVAYGSQEKDKVVNIVTPLLYNITPYLKNHTARNVPFFYACSALLASLS 2243
|:.|.::|:.:|::|||:.:.|.||::|:.::..:::.:.|||:||:|.|.|.:.||..||:|||
Rat 2031 SVHALTLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLS 2095
Fly 2244 GYQYTRKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNI 2308
||||||:||:|:..||.:|.:||||..||:..||.|||:|||:|.||||:|||||:::|:.|||:
Rat 2096 GYQYTRRAWKKEAFDLFMDPSFFQMDASCVSHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSSLNL 2160
Fly 2309 FTSRDQEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVL 2373
|.:||.|.||||||||||||.|:.||.||:.||:|||||:|..|||| |..|::.:.|||.||||
Rat 2161 FANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRL-PQVPTLHSQVFLFFRVL 2224
Fly 2374 LLRMSPDHVTSLWPIIIAEMVQVFLQMEQELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQ 2438
||||||.|:|||||.:|.|:|||||.|||||.::.:.........:|::.:::..:|.|..|||
Rat 2225 LLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSAAGLETTYTGGNGFSTSYNS- 2288
Fly 2439 TPMQHWRSVQLEACKLLELGCVLPATKLPHFQMYRWAFVGTEFD----------VHEEEVCLPNG 2493
|.|.::.|.|||.|:|...||:..||.||||||||:....| :|:.|
Rat 2289 ---QRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGIHQRE------ 2344
Fly 2494 SLENLATLPSALYVPHVRRVARLM--------DMKYTSQSPILQRPSN--------------RHL 2536
:.|:|.|:|:|: |.|......:.:...| .||
Rat 2345 ------------FKPYVVRLAKLLRKRAKDEEDFKILEGLEMAKHQKNPEEDGSARTLGWEPGHL 2397
Fly 2537 MLHFQQLQSLQELYAFFTTLG--------------------ISCPQPRNFADTENDVA---NCLK 2578
:|....::::::|..||..|. .|...|......||..| ...:
Rat 2398 LLTLCTMRNMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNSFPSKDMKLENHKAFSSKARQ 2462
Fly 2579 EIEEVLANDFLE 2590
:|||::..||||
Rat 2463 KIEEMIEKDFLE 2474
| 
