DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15099 and SPAPB21F2.02

DIOPT Version :9

Sequence 1:	NP_001261081.1	Gene:	CG15099 / 37176	FlyBaseID:	FBgn0034400	Length:	2683	Species:	Drosophila melanogaster
Sequence 2:	NP_592953.1	Gene:	SPAPB21F2.02 / 2543220	PomBaseID:	SPAPB21F2.02	Length:	1687	Species:	Schizosaccharomyces pombe

Alignment Length:	2715	Identity:	467/2715 - (17%)
Similarity:	808/2715 - (29%)	Gaps:	1177/2715 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLAQCMHPAL 80
            :||||.|...|.|.:..|:...:|.|.||.|.||.|.:.:::.:..||..|.:::.||:|:.|.|
pombe    10 DAKYRKYQDAIRKCIALFQTVEQWPDYISFLTKLHKVLQTHSSFVNIPCSLLVSRALAECLSPGL 74

  Fly    81 PSGVHLKALETYSVIFSKTGPERLATEF-IYSAGLFPLLGYAAMNVRPALLAIYETYFVPLGDKL 144
            |||||.|.||.|..||:..|.:.|..|. .:|.||.|....:::..:...:.|.:.::|.||..:
pombe    75 PSGVHKKTLEVYDYIFTIIGSKTLTNELSTWSYGLTPFFSISSIKTKHDYINIIKKHYVSLGVGI 139

  Fly   145 RPALSGFLNGVLPGYDCGLDH-FERISALLKQVCNAVNPMHF-YTVLWESVANNAAIRLPAITYL 207
            ||........:|.|.:..:|. .:.:..||..:...:|...| :..:|.::.:..:.|..|:.||
pombe   140 RPCFQAVFISLLSGLEEDVDESSQEVYHLLDDLVKVLNDEKFAWGCIWSTILSFPSQRPGALAYL 204

  Fly   208 LEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSE---DD 269
            |...|...:...|..::..:..:::.:....::|:.|||||..::.||..||:.:....:   .|
pombe   205 LRVCNNLAEEDIQTRVIQPDSGLVVRSFAAAISDNDILVQRGYMDALLNYFPIQSTFYKDVKPFD 269

  Fly   270 LVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHSRH 334
            |..|..:..:.:||.|:|||||.::||:|  ::|::    .||:..|:..::|..    ::.:..
pombe   270 LKLLHMSVASIVLRNDLSLNRRFYAWLMG--LSKDT----ELSISDSSITVDENT----LQQNMA 324

  Fly   335 ILIKALITTLRLSLECAPMDLKPYRIMLSLLDKAE----IGSAVLDYVLH-----------DIIR 384
            |..:. :..|..|........|.:||:.:|.|:..    :.|.:|..|||           |..:
pombe   325 IFFEG-VKDLLSSKNSLMSFYKAFRILYALSDRRPLFTIVESQILPCVLHSYETLTNVFHRDDSK 388

  Fly   385 AMYISSGNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQEKSQAGETSGKYACDVGSG 449
            .:|.|     |:.....|...|..:.:.:::.:...|..  ||: .|.|.:.| :.|:..|
pombe   389 HLYES-----AVDHGRRLIMKFSDSELHTFLFHCVNKIV--ANT-TENSDSAE-AVKFILD---- 440

  Fly   450 DPCVLEICVLTEFLLETVSLEMYTETTRVYLPKVFLAITQLLSLHMDHISSNEITASLKLCMKIV 514
                     ...|..|:::.| |:          |:..|.|| :|::..|.|.....:.:.:..:
pombe   441 ---------SQNFFFESINTE-YS----------FIIFTNLL-MHLEKTSPNSDVDGVSMTILTI 484

  Fly   515 SRVQPMITSPIKLNKLIEQSGGSSSDEKITMNSASDAGKTEAGAQGNSLEKSKSDSRLNQFAENT 579
            .::   :.:....|.....:....|..|.|:|..||                        |....
pombe   485 CKI---LLNNFDWNFFNYNNSAIDSYAKCTLNLDSD------------------------FENGI 522

  Fly   580 LHSADPNDEELIHRSASNQSVGRQSPNKKKAKSISRLSELDKD---------IS------ASDTG 629
            |      ..|::::             |.|...:|.|.:..||         ||      ||||
pombe   523 L------TYEILYK-------------KCKCSLLSLLKQYIKDSHVHHEVLLISLNLIKEASDT- 567

  Fly   630 QQSSSDLDTPRSIKKLKAKA-KVPFIRSPKKQRPKDMVLIQSNTSAEVSDGPSAEEPKSAPPDQT 693
            :..:..||.  |::..|..: ....:.|..||.| ..:||.|.....|
pombe   568 EFENEFLDL--SLQGFKDNSWSFQTLGSFVKQLP-SRILINSTACVNV----------------- 612

  Fly   694 PQFQLDEESRATQQRGFSILEK-----CI----RQYEIFFEVYLSRKLLH---IESEPKECSVKV 746
                              ||::     |:    |:.|:...::..::.|.   |||....|.||.
pombe   613 ------------------ILDRIWCELCMFSYFREEELLSVIWTLQEKLQTRIIESYFSTCIVKE 659

  Fly   747 QLQRTTSTIHTSNLF-----MAEQVLDHECPVRESQIERLFNLLRVDIVPRS-KQLQRLLNRSLP 805
            ||:....||:.:..:     .|:|.|.|.  |.:..:..|.|.|..|...|. ..:...:|.|..
pombe   660 QLELRAPTIYYTPFYNLLKKSAQQSLFHF--VFDRPLLLLLNSLLEDESGRDYTAMMNWINASSS 722

  Fly   806 LPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLVEMSTFPNCN 870
            |.....||.:::                        .|.|||:|.....|...:     |..|.|
pombe   723 LQLRVLELMTEN------------------------LLSLSPNLTSVNSLETAM-----TRYNIN 758

  Fly   871 KHVVLDKNEPELPN---WLKVLCLVACFAQ----------SDKELQVASITTLFDLISLLRSQIE 922
            :    |:...|...   :||:...:..:.|          |.|:::...:.|..|.:.:.:..:
pombe   759 E----DQRNSEASRCVYFLKLCTRIISYFQDLHPKEGRLKSAKQVEELCLVTWADALLIQKKSL- 818

  Fly   923 HTTSPGVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTAGIDPAQIAALLHQLHSCLES 987
             |.|..:.|:|.|.|........::..|.|:.:.:..|               .||:|:.|..|:
pombe   819 -TYSSFLAFLVKLCLDIVLTPQNIKTSTDVYIIQTWAL---------------RLLYQITSIWEN 867

  Fly   988 GLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEAQLLCPTESTERLRESQARSFKK 1052
            .|                 :.:|...:|..|:                .:..||...|..||| .
pombe   868 PL-----------------KFESSLIVGLFAL----------------VQEVERSPSSTYRSF-I 898

  Fly  1053 FELLWHLGRDKQTARGFEKTLLKVLD-TLAL---PHYMSERTFVTNWLQASLLRGDLARLTKPLY 1113
            ..||..|           :.||..|| |:.|   .||:     ::|::...:|..|.....|.|:
pombe   899 LSLLQML-----------EFLLSRLDGTIDLSSEQHYL-----LSNFVLVGMLNDDPGLSPKWLH 947

  Fly  1114 KILLSASSKRVGIVHMQQLYRESETEVTPAFERDVYAISSEQGNVKYHHMETSSGNKKKSPIRNF 1178
            .|
pombe   948 AI--------------------------------------------------------------- 949

  Fly  1179 PKKIFGVTLSGGKANKVSNFVSDKSTVATCSEATQDMNTIGLIINPLENANDFDDETDLEEPRIE 1243
             ||:..:.|                           .|...|::||:::...|
pombe   950 -KKLLPLLL---------------------------QNLQLLMVNPIQSLCKF------------ 974

  Fly  1244 IPHKETPLEQKLASAMDESEQPSQEQPANQPDNSLQYDQDITDHSDSSDFESDSELRETSIEKED 1308
                       :.|.:|:.|           ...|:|...:.|::
pombe   975 -----------VHSFLDQHE-----------SMYLKYPDPVKDYA-------------------- 997

  Fly  1309 SITVSSSAGVSDDVKRFVGDCESVTDALTQHEKIKSRKTYRLTREKTPGENSLNSLEQKDHDSIS 1373
                                |..|..|     |:|                           .:|
pombe   998 --------------------CMDVFIA-----KLK---------------------------MLS 1010

  Fly  1374 ELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSCISKTSTDSNISGSHVEQPEQEEETEPGTE 1438
            ||.:.||....|              :.|.||           ||:..:.:
pombe  1011 ELVSAALLEFTY--------------SPGPKK-----------SNLEANGI-------------- 1036

  Fly  1439 STINVEDKRRNLSLETSKLQPDMQKTLEKGKQNVEILRQNNAAAAAAAAAAAEEQISVRSSMKST 1503
                                                  ..|..:...||.::...|.|...:...
pombe  1037 --------------------------------------IGNVISGVFAAESSGVSIDVNKRLSML 1063

  Fly  1504 VSLTDAAHLYHNHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFLCLS--ITTSFSSASLKQLL- 1565
            :::.|                       |||||          ||..|  |.:|::..:.|..:
pombe  1064 LTMQD-----------------------ALQTL----------FLSYSWHIRSSYADKTSKVFMN 1095

  Fly  1566 ---VRHRKSISGKGFDGSVGNSEYAQGYRGCMQLELLVTLCLFYARGYFQKESLDAQRQSPTLQD 1627
               |....|:||            .:.:..|..||.:.||...|
pombe  1096 DSSVLKEASLSG------------LKEFYFCEPLECVETLVQIY--------------------- 1127

  Fly  1628 IVNNRRIQLESIELLTLICSELIEIVKGMGRGLANYIADLLARAKLQKVMLHCLNSSVCSYGLKG 1692
            :.||       :|     |.:.|
pombe  1128 LENN-------VE-----CCQCI------------------------------------------ 1138

  Fly  1693 NTNSGSYAEQVLSFNDPQDDQLHADCFQLQLLRLLLAVIRLEHEVHQLRQDTPPAAGEDSAGNAS 1757
                    ..:.||
pombe  1139 --------WDIFSF--------------------------------------------------- 1144

  Fly  1758 PTRLAEGATANVKYLPNCLISQQPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNI 1822
                              |...:|.:
pombe  1145 ------------------LSDSEPQY--------------------------------------- 1152

  Fly  1823 VISVVHQLCSNLDRISKMGLPQQRHFPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQ 1887
               :|.||.|:.  .::.|:..  :..|..:.:::..|.|||  |:.|..
pombe  1153 ---IVKQLVSSF--FAREGIAS--YAGPSSLTAKITQLDILC--CMSDFV--------------- 1193

  Fly  1888 TSSSAQSSSTGQLLNSI---VHSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIWD 1949
              |..:..:|.::...|   |...:|:|.|              .:|.:|..|
pombe  1194 --SRVEGENTSKIFTEISKFVREIISSSNS--------------FKNYLLVCL------------ 1230

  Fly  1950 SELGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACPA 2014
                      :.|||                         :|.|:|  :..|..|:...:.....
pombe  1231 ----------RMLLE-------------------------VAKNVN--TYCESRQQKDFIDLMGK 1258

  Fly  2015 QLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPP--------IHRPPAQLSIEV-------SALELF 2064
            .||.|                 |.|..:|..|        .|:..|. :.||       |::.||
pombe  1259 TLSSV-----------------LFHAGKSSDPNLTVDFLAYHKAAAD-TFEVAKTQKKTSSVYLF 1305

  Fly  2065 YFYMKSAPAPQLADAWSSLLALIRDGLNLTPPAQFALLMLLNEFVQRCPQMPFQDKKEVRELHDV 2129
            ..|:.    |.|.|.:.|                        |||.:..::
pombe  1306 VKYLD----PSLLDFFCS------------------------EFVPKITEL-------------- 1328

  Fly  2130 TSRLVDSLSSVAGSCLEQTTWLRRNLAVKEDTDGLAKDNSVGGGGLQQYSLQAQSVLAAILSNLL 2194

pombe  1329 ----------------------------------------------------------------- 1328

  Fly  2195 DVAYGSQEKDKVVNIVTPLL-YNITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDMLD 2258
                 |:|:||:|...|.:: ..|||.:|..|.......|....||. ||.:.:..|:||:|..:
pombe  1329 -----SKEEDKLVAWATSIVNVFITPLVKARTFPESLTTYHLDLLLV-LSKHPFLSKSWRRDFWE 1387

  Fly  2259 LLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAMLL 2323
            :..||:.|:..:..|.....::.:.:..:.:...:|:|:   |..|...:|||||.:...|...:
pombe  1388 IFNDNSLFRFDIDQLRKLSPVIYTALYQEISRLNDLITK---SDLGVTTLFTSRDTQLGARQSNI 1449

  Fly  2324 KRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPS--VQAAVFLCFRVLLLRMSPDHVTSLW 2386
            .|:..::..|..|   .::|.:...:....||:...|.  ::..:||..|.|.||.|..|:..||
pombe  1450 CRITILMLSSPRD---FFLPSLPPLIDLVKRLITSDPEGVLKKDLFLFIRALALRTSSKHLLPLW 1511

  Fly  2387 PIIIAEMVQVFLQMEQELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQTPMQHWRSVQLEA 2451
            ||:::|::.:|               :...:|: :.:|                    :...|:|
pombe  1512 PIVVSELLIIF---------------KSYCMPN-VAIS--------------------KETLLDA 1540

  Fly  2452 CKLLELGCVLPATKLPHFQMYRWAFVGTEFDVHEEEVCLPNGSLENLATLPSALYVPHVRRVARL 2516
            |:||:.   |.|.||..|.::.|..:.:..|                     |:|.
pombe  1541 CRLLDF---LTALKLEEFALHEWVVMLSPLD---------------------AVYW--------- 1572

  Fly  2517 MDMKYTSQSPILQRPSNRHLMLHFQQLQ-----SLQELYAFFT------TLGI--SCPQPRNFAD 2568
              ...||:..::|:.|.|   |..|..:     |::..::..|      :|||  :..|.|||.:
pombe  1573 --SGKTSRKSLVQKVSER---LQEQASEKDDKSSVESEHSILTSTTRTPSLGIYTTDAQLRNFLN 1632

  Fly  2569 T--------------------ENDVANCLKEIEEVLANDFLEKLPSITTP 2598
            .                    ||.:   .:|:.:..:|..|....||..|
pombe  1633 RISIDAYEESYSFSTIDIQSFENSI---YREVLQRFSNAPLSPFSSIKAP 1679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15099	NP_001261081.1	Dopey_N	18..304	CDD:282036	86/291 (30%)
CG15099	NP_001261081.1	Dopey_N	<2200..2477	CDD:296427	68/279 (24%)
SPAPB21F2.02	NP_592953.1	DOP1	1..1663	CDD:227546	462/2697 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	141	1.000	Domainoid score	I1212
eggNOG	1	0.900	-	-		E1_COG5221
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003065
OrthoInspector	1	1.000	-	-		oto101382
orthoMCL	1	0.900	-	-		OOG6_102162
Panther	1	1.100	-	-	LDO	PTHR14042
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R332
SonicParanoid	1	1.000	-	-		X2429
TreeFam	0	0.000	Not matched by this tool.
	9	8.930