DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG15099 and DOP1A

DIOPT Version :10

Sequence 1:NP_001261081.1 Gene:CG15099 / 37176 FlyBaseID:FBgn0034400 Length:2683 Species:Drosophila melanogaster
Sequence 2:XP_016866048.1 Gene:DOP1A / 23033 HGNCID:21194 Length:2485 Species:Homo sapiens


Alignment Length:2870 Identity:894/2870 - (31%)
Similarity:1402/2870 - (48%) Gaps:681/2870 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73
            ||.:|::::|||.|:..|||||:||||||||||||||||||:|.:.:|.:|||:|::|.|.||||
Human     4 EELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKKLTIGKRLA 68

  Fly    74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137
            ||:|||||.|||.||||||.:||...||:|||.: |:||:||||||..|||:|:|.||::||.|:
Human    69 QCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMSVKPTLLSLYEIYY 133

  Fly   138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202
            :|||..|:|.|.|.|.|:|||.:.|.:::||.:.||::|..||:...||:.||.|:..:.|:|||
Human   134 LPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSAFYSALWGSLLTSPAVRLP 198

  Fly   203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSE 267
            .|||:|.|.|::|.|::|:||:|.:.|:|:.|:...:.||.:||||:||:.:|..||.|....:.
Human   199 GITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATR 263

  Fly   268 DDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHS 332
            .|::::::..|:.:|||||||||||::||||.:  .|.......|...||.  ||....||...|
Human   264 PDMIRILSAALHVVLRRDMSLNRRLYAWLLGFD--NNGAIIGPRSTRHSNP--EEHATYYFTTFS 324

  Fly   333 RHILIKALITTLRLS----LECAPMDLKPYRIMLSLLDKAEIGSAVLDYVLHDIIRAMY------ 387
            :.:|::|::..|:::    ......||||:||::|||||.|:|..:|:.||.::.|.:|      
Human   325 KELLVQAMVGILQVNGFGEENTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAE 389

  Fly   388 ---------------ISS------GNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQE 431
                           :||      ..||.:|:|||||.:|:|.|:|.|:...||:.|::...::.
Human   390 LDLQTEPPFSKDHAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYVARWFEECCRRTLHVRL 454

  Fly   432 KSQAGETSGKYACDVGSGDPCVLEI---CVLTEFLLETVSL----------EMYTETTRVYLPKV 483
            :...|:          |.|...|::   |:|.:|||:.|||          |.|.|....:||::
Human   455 QIGPGD----------SNDSSELQLTNFCLLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHLPQL 509

  Fly   484 FLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSS-----DEKI 543
            .|.:...|:.|:..:..:|:|.||:||.||:|:|||.:.|......|...||.::|     |:|:
Human   510 LLRMISALTSHLQTLHLSELTDSLRLCSKILSKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKV 574

  Fly   544 TMNSASDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQSPNKK 608
              :|.|....||....|.:...|:|..  :.|.|...:.||                        
Human   575 --SSVSHENPTEVFEDGENPPSSRSSE--SGFTEFIQYQAD------------------------ 611

  Fly   609 KAKSISRLSELDKDISASDTGQ--------QSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDM 665
                  |..::|:::|   .||        .:||:.:|..::                   ..:.
Human   612 ------RTDDIDRELS---EGQGAAAIPIGSTSSETETASTV-------------------GSEE 648

  Fly   666 VLIQSNTSAEVSDGPSAEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSR 730
            .:||  |.:.|:.|.:.                  .||.|.|:  :.::.|:.    :.:.:|:|
Human   649 TIIQ--TPSVVTQGTAT------------------RSRKTAQK--TAMQCCLE----YVQQFLTR 687

  Fly   731 KL-LHIESEPKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSK 794
            .: |:|          :|          :|.|......:|:..:...|.|               
Human   688 LINLYI----------IQ----------NNSFSQSLATEHQGDLGREQGE--------------- 717

  Fly   795 QLQRLLNRSLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATL 859
                         .|..:.:|..:.:|                :.:::.:.|.....|...|..|
Human   718 -------------TSKWDRNSQGDVKE----------------KNISKQKTSKEYLSAFLAACQL 753

  Fly   860 LVEMSTFP------NCNKHVVLDKNEPEL-----PNWLKVLCLVACFAQSDKELQVASITTLFDL 913
            .:|.|:||      |....:..:|.|.:.     |.||:.| :.||...||..:|..:|:.:.||
Human   754 FLECSSFPVYIAEGNHTSELRSEKLETDCEHVQPPQWLQTL-MNACSQASDFSVQSVAISLVMDL 817

  Fly   914 ISLLRS----------QIE--HTTSP--GVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYL 964
            :.|.:|          .:|  ...||  |...||:.|.|..|::.|:.:.|..|:.|:..|||.|
Human   818 VGLTQSVAMVTGENINSVEPAQPLSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQL 882

  Fly   965 GTAGIDPAQIAA-LLHQLHSCL-ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERL 1027
            |.......|.:. |.:|||:.: .|.:.|.||     ||.|                        
Human   883 GDGTPQHHQKSVELFYQLHNLVPSSSICEDVI-----SQQL------------------------ 918

  Fly  1028 AEAQLLCPTESTERLR-ESQARSFKKFELLWHLGRD------KQTARGFEKTLLKVLDTL-ALPH 1084
                    |...:::| |:.|    ||.:||||.||      ....|.|:::|..:||:| :|..
Human   919 --------THKDKKIRMEAHA----KFAVLWHLTRDLHINKSSSFVRSFDRSLFIMLDSLNSLDG 971

  Fly  1085 YMSERTFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVY 1149
              |..:....||...|.|.|:||:.:||..:||...::||.:..:|.....:::...|..|.|.:
Human   972 --STSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWNKSPCYPGEESDKH 1034

  Fly  1150 AISS-EQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDK-STVATCSEAT 1212
            .:.: ...||....:.||.||.:| |:.....:.|.:|:         |.:||: |.::|.||  
Human  1035 FMQNFACSNVSQVQLITSKGNGEK-PLTMDEIENFSLTV---------NPLSDRLSLLSTSSE-- 1087

  Fly  1213 QDMNTIGLIINPLENANDFDDETDLEEPRIEI--------------PHKETPLEQKLASAMDESE 1263
                ||.:::      :||    ||.:.:|||              .:....::.:..:|.::|:
Human  1088 ----TIPMVV------SDF----DLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQ 1138

  Fly  1264 QPSQEQPANQPDNSLQ---YD--------QDITDHSDSSDFE--------SDSELRETSIE-KED 1308
            .|.:    :.||:.:|   :|        .::...|.:|..|        ||.:..|.:|: ::|
Human  1139 MPKE----SSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDD 1199

  Fly  1309 SITVSSSAGVSDDVKRFV-----GDCESVTDALTQHEKIK--SRKTYRLTREKTPGENSLNSLE- 1365
            ||..|.:|.:|::..:|:     |..|.|.:.::::....  |..|:.|      .::|:.|:| 
Human  1200 SIQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTL------HDSSVASIET 1258

  Fly  1366 ---QKDHDSISELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSCISKTSTDSNISGSHVEQP 1427
               |:.|.||.            |...:||.::              :|:..|....||.     
Human  1259 KSRQRSHSSIQ------------FSFKEKLSEK--------------VSEKETIVKESGK----- 1292

  Fly  1428 EQEEETEPGTESTINVEDKRRNLSLETSKLQPDMQKTLEKGKQNVEILRQNNAAAAAAA-----A 1487
                  :||.:..:.:..|:.:                :|.|.:.|.|:|.:...:...     .
Human  1293 ------QPGAKPKVKLARKKDD----------------DKKKSSNEKLKQTSVFFSDGLDLENWY 1335

  Fly  1488 AAAEEQIS-VRSSMKSTVSLTDA---AHLYHNHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFL 1548
            :..|..|| :.|.|.|..|....   .|..:.|:|:||.:||:.:||||...::.|:..:...|:
Human  1336 SCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSRTLYAFSAIKAILKTNPIAFV 1400

  Fly  1549 CLSITTSFSSA------SLKQLLVRHRKSISGKGFDGSVG-NSEYAQGYRGCMQLELLVTLCLFY 1606
            ....|||.::|      .|:.||.|||.|:.||.|...:. :|.:  .:|..|.:|:|::|||:|
Human  1401 NAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIPVDSNH--NFRSSMYIEILISLCLYY 1463

  Fly  1607 ARGYFQKESLDAQRQSPTLQDIVNNRRIQLESIELLTLICSELIEIVKGMGRGLANYIADLLARA 1671
            .|.::      ......|.||::.||.:|:.|||:|||:.:||.::::...:|..::|:|:|::.
Human  1464 MRSHY------PTHVKVTAQDLIGNRNMQMMSIEILTLLFTELAKVIESSAKGFPSFISDMLSKC 1522

  Fly  1672 KLQKVMLHCLNSSVC------SYGLKGN----TNSGSYAEQVLSFNDPQDDQLHADCFQLQLLRL 1726
            |:|||:||||.||:.      |..:.|.    ...|...:.:::|::.:.|  :....|.|||::
Human  1523 KVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFSEDSLINFSEDEFD--NGSTLQSQLLKV 1585

  Fly  1727 LLAVIRLEHEVHQLRQDTPPAAGED----SAGNASPTRLAEGATANVKYLPNCLISQQPMFLAAV 1787
            |..:|.|||.|..:.::.  ..|.|    ...:.||.:    ...:::||....|:.|.|||.||
Human  1586 LQRLIVLEHRVMTIPEEN--ETGFDFVVSDLEHISPHQ----PMTSLQYLHAQPITCQGMFLCAV 1644

  Fly  1788 LGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNIVISVVHQLCSNLDRISKM-----GLPQQRH 1847
            :.||.|.....:|..|..|:||:|. :....|..:|:||..|||.|||.:.:.     ||...|.
Human  1645 IRALHQHCACKMHPQWIGLITSTLP-YMGKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDSRP 1708

  Fly  1848 ------FPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSSTGQLLNSI-- 1904
                  .|||.:::.||.:|.:.||||||.|.|   .|                   |||.|:  
Human  1709 LWMASIIPPDMILTLLEGITAIIHYCLLDPTTQ---YH-------------------QLLVSVDQ 1751

  Fly  1905 VHSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIW------DS------------- 1950
            .|.|                   .||:.:||.|..|||||..:|      ||             
Human  1752 KHLF-------------------EARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLT 1797

  Fly  1951 --ELGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACP 2013
              .||..:.:|||:||.|.|:|::||.:|:||:|..|.:|            .|.:..:..:..|
Human  1798 TINLGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNER------------RQNKTTTRTKVIP 1850

  Fly  2014 A----QLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPPIHRPPAQLSIEVSALELFYFYMKSAPAP 2074
            |    ||.||.||.||.||..::.:.|:..|::.||.|.:....||:||..|:.||.|::..|.|
Human  1851 AASEEQLLLVELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVP 1915

  Fly  2075 QLADAWSSLLALIRDGLNLTPPA--QFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSL 2137
            .|.|:|:|||.|::|.:.|:.||  ||.:|.:||||:.:.|.:  ::||:.|:|.|||.::||::
Human  1916 NLVDSWASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSL--ENKKDQRDLQDVTHKIVDAI 1978

  Fly  2138 SSVAGSCLEQTTWLRRNLAVKEDTDGLAKDNSVGGGGLQQ-------------------YSLQAQ 2183
            .::|||.|||||||||||.||.....:     |.|..|:.                   ||:.|.
Human  1979 GAIAGSSLEQTTWLRRNLEVKPSPKIM-----VDGTNLESDVEDMLSPAMETANITPSVYSVHAL 2038

  Fly  2184 SVLAAILSNLLDVAYGSQEKDKVVNIVTPLLYNITPYLKNHTARNVPFFYACSALLASLSGYQYT 2248
            ::|:.:|::|||:.:.|.||::|:.::..:::.:.|||:||:|.|.|.:.||..||:||||||||
Human  2039 TLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGYQYT 2103

  Fly  2249 RKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRD 2313
            |:||:|:..||.:|.:||||..||:..||.|||:|||:|.||||:|||||:::|:.|||:|.:||
Human  2104 RRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSSLNLFANRD 2168

  Fly  2314 QEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMS 2378
            .|.||||||||||||.|:.||.||:.||:|||||:|..|||| |..|::.:.|||.|||||||||
Human  2169 VELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRL-PQVPTLHSQVFLFFRVLLLRMS 2232

  Fly  2379 PDHVTSLWPIIIAEMVQVFLQMEQELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQTPMQH 2443
            |.|:|||||.:|.|:|||||.|||||.::.:.........:|::.:::..:|.|..|||    |.
Human  2233 PQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYTGGNGFSTSYNS----QR 2293

  Fly  2444 WRSVQLEACKLLELGCVLPATKLPHFQMYRWAFVGTEFD----------VHEEEVCLPNGSLENL 2498
            |.::.|.|||.|:|...||:..||.||||||||:....|          :|:.|           
Human  2294 WLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGIHQRE----------- 2347

  Fly  2499 ATLPSALYVPHVRRVARLM-----DMKYTSQSPILQ---------RP----SNR-------HLML 2538
                   :.|:|.|:|:|:     |.:...::.||:         .|    |.|       ||:|
Human  2348 -------FKPYVVRLAKLLRKRAKDKEEDFKTVILEGLEMAKHQKNPEEDNSGRTLGWEPGHLLL 2405

  Fly  2539 HFQQLQSLQELYAFFTTLG--------------------ISCPQPRNFADTEND---VANCLKEI 2580
            ....::|:::|..||..|.                    .|...|......||.   .:...::|
Human  2406 TICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKI 2470

  Fly  2581 EEVLANDFLE 2590
            ||::..||||
Human  2471 EEMVEKDFLE 2480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15099NP_001261081.1 Dopey_N 17..301 CDD:461183 154/284 (54%)
Dopey_N <2200..2477 CDD:471021 150/276 (54%)
DOP1AXP_016866048.1 Dopey_N 11..294 CDD:461183 152/282 (54%)
Dopey_N <2091..2327 CDD:471021 136/240 (57%)

Return to query results.
Submit another query.