Protein Alignment CG15099 and pad-1

DIOPT Version :9

• Sequence 1: NP_001261081.1
• Gene: CG15099 / 37176
• FlyBaseID: FBgn0034400
• Length: 2683
• Species: Drosophila melanogaster
• Sequence 2: NP_493252.3
• Gene: pad-1 / 173156
• WormBaseID: WBGene00003905
• Length: 2417
• Species: Caenorhabditis elegans
• Alignment Length: 2900
• Identity: 713/2900 - (24%)
• Similarity: 1154/2900 - (39%)
• Gaps: 823/2900 - (28%)

  Fly    16 EAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLAQCMHPAL 80
            ::|||.|...||:||:.||..:||||||||||||:|...||.::..||.|:.:||||:||:||||
 Worm    16 DSKYRAYAKAIDQALKTFETPNEWADLISALGKLAKVFQSNAKFCAIPNRVTVAKRLSQCLHPAL 80

  Fly    81 PSGVHLKALETYSVIFSKTGPERL-ATEFIYSAGLFPLLGYAAMNVRPALLAIYETYFVPLGDKL 144
            |.||||||||||..||...||.:| ...::::.|||||:.:..:.|:..|..|:|.|.||||..|
 Worm    81 PMGVHLKALETYRQIFEILGPNKLPECLYLFAVGLFPLMDHCGIKVKSELFTIFENYLVPLGANL 145

  Fly   145 RPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLPAITYLLE 209
            ||||.|||.|||...:.|.:.:||...||.:||..|.|..||..||:::..:..:||||:.|:..
 Worm   146 RPALPGFLGGVLLALEEGTEFYERSFILLDRVCEKVGPRAFYACLWQAILGSPPVRLPAMIYVNA 210

  Fly   210 HFNKRLDMQEQIYIMGHNREIMMSALCVCLNDS-LILVQRNTLEFLLLGFPMHTVLLSEDDLVKL 273
            .|:|...:.:||:::|.:...|::|||...:|: ..||||..|:||:..||:.:..|:.:|.|:|
 Worm   211 KFDKLKSLDDQIHLVGDHVNHMVAALCAVADDTGSPLVQRYLLDFLVAAFPLDSTNLTNEDFVQL 275

  Fly   274 VTNGLNTILRRDMSLNRRLFSWLLG--------SEVAKNSP------TY--------------DT 310
            :...|..:|||||||||||::||:.        |.::...|      |:              :.
 Worm   276 LRRCLFVVLRRDMSLNRRLYTWLINRSGETKGVSGLSLGGPDDGIELTFFKERVLGLVHGALGEY 340

  Fly   311 LSLDTSNAPLEEEPEPYFVKHSRHILIKALITTLRLSLECAPMDLKPYRIMLSLLDKAEIGSAVL 375
            |:|||...|        |..|.     .::....:.:.:....:::..|::|.|.|:|:||..:|
 Worm   341 LALDTIETP--------FANHQ-----NSMWGDRKEAEQVQFAEVRVCRLLLYLQDRADIGRTIL 392

  Fly   376 DYVLHDIIR--AMYISSGNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQEKSQAGET 438
            :.|..|.::  |.:.||.|:.:||.:                    .:..||  |::...:.|:.
 Worm   393 ETVFADFLKKSAEFHSSSNSSSLKKS--------------------PRKIQQ--SLKNPRKPGDR 435

  Fly   439 SGKYACDVGSGDPCVLEICVLTEFLLETVSLEMYTETTRVYLPKVFLAITQLLSLHMDHISSNEI 503
            .|.|
 Worm   436 EGLY------------------------------------------------------------- 439

  Fly   504 TASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSSDEKITMNSASDAGKTEAGAQGNSLEKSKS 568
                                 :.||.:...|........:|.::|::|.......:.:.::..:.
 Worm   440 ---------------------LDLNSVCSTSNKDDDVTSVTSSAAANASSAPPPDEEDLVQARRI 483

  Fly   569 DSRLNQFAENTLHSADPND-----EELIHRSASNQSVGRQSPNKKKAKSIS-RLSELDKDISASD 627
            | .|::.....|:|.:|..     .:...|...|....||..:..:..|:. .:..::.|
 Worm   484 D-ELSKTFNMLLNSLEPGFLWTFLGDWYRRIVENNEFERQIHDFSQVVSVCLEMCNVESD----- 542

  Fly   628 TGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLI-QSN----TSAEVSD--------G 679
                                    |.||:....|..:.||. .||    :|.:.||        .
 Worm   543 ------------------------PTIRTQHLPRLLETVLEGVSNKNLLSSCDQSDLLQLYTVCQ 583

  Fly   680 PSAEEPKSAPPDQTPQFQLDEESRATQQRGFSI----------LEKCIRQYEIFFEVYLSRKLLH 734
            ...|...:.||......::.|:|.:..|...:|          |.:|:......||:|.:|
 Worm   584 KLLEISTAHPPSPIEVDEIAEDSLSMSQEVTAIEHERSQTDACLSQCLSALSAIFEIYTTR---- 644

  Fly   735 IESEPKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQRL 799
                 :|.|:...:..:|:.:   |.|:       |.|:         ..|...||.......|
 Worm   645 -----REASLIPLIDASTTLL---NAFL-------EVPI---------YYLGFGIVDNPGDYCR- 684

  Fly   800 LNRSLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLVEMS 864
                              |:.||.|                      |.|:..:|
 Worm   685 ------------------ESSEEVQ----------------------PWLKNMLK---------- 699

  Fly   865 TFPNCNKHVVLDKNEPELPNWLKVLCLVACFAQSDKELQVASITTLFDL--------ISLLRSQI 921
                     |:|.     |.||:.:....|       ..|::..:|.:|        :.:|....
 Worm   700 ---------VIDG-----PGWLREMRAGLC-------ADVSARASLLELLCKIYVKSVQVLEQHE 743

  Fly   922 EHTTSP------GVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYLGTAGI--DPAQIAALL 978
            |....|      .:|.|::.|||......::|| .:||......:|..:|:...  :..::|.||
 Worm   744 EAAHRPHDDFYDEMTHVLLKPLLAKRDCQFIEQ-GKVFGTCGEAVWLGIGSRKFCTEQQRLARLL 807

  Fly   979 HQLHS--CLE-SGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERLAEAQLLCPTESTE 1040
            .:|||  .|| |..||:::           :||.:.:|                 .|:|
 Worm   808 VELHSRRPLEASSDVESIV-----------VQSLTSTD-----------------DLVC------ 838

  Fly  1041 RLRESQARSFKKFELLWHLGRDKQT--------ARGFEKTLLKVLDTLALPHYMSERT----FVT 1093
               ...||:|.:   :|.|.|:.:.        .:.|.:.::.:|..||.......||    ...
 Worm   839 ---SEAARTFHR---IWVLARNLEDREQQGIPYQKPFNRAVMILLGVLADESVAKTRTELKAAAA 897

  Fly  1094 NWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVT----PAFERDVYAISSE 1154
            .|........||.|:.:.|..:|::..:.|:.|.:::|     ||::|    |....|:.|::
 Worm   898 EWFHDCSKHQDLPRIVQMLSTMLMNPVTARISIQYIRQ-----ETKMTTDTCPVIPADISAVT-- 955

  Fly  1155 QGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDKSTVATCSEATQDMNTIG 1219
                    :.|..|.          ::::.||  |..|      :...||.:|         .|.
 Worm   956 --------LVTIDGK----------QRLYHVT--GQPA------IDSSSTEST---------WIT 985

  Fly  1220 LIINPLENANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPANQPD-NSLQYDQD 1283
            .:.|.|...:..:|..|             |.....|..:..|.......||...| :||    |
 Worm   986 EVRNRLLRTSTGEDSGD-------------PSAAGAAGILRSSSPDPDVVPAFDDDTDSL----D 1033

  Fly  1284 ITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGDCESVTDALTQHEKIKSRKTY 1348
            ....|||.|......|||                :.|.|      ||...:...:.|:|.:  .:
 Worm  1034 TLSMSDSIDETVIHVLRE----------------IVDQV------CEEFNEEDLERERIMT--MF 1074

  Fly  1349 RLTREKTPGENSLNSLEQKDHDSISELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSCISKT 1413
            .:...:..|.:.....:.:..|.::|..|...| |...:..||..:|:..|
 Worm  1075 AMDNVEPTGASFNLPHDSEADDEVAERPAPICP-DSLVQRVKKGHRRQDSL-------------- 1124

  Fly  1414 STDSNISGSHVEQPEQEEETEPGTESTINVEDKRRNLS-LETSKLQPDMQKTLEKGKQNVEILRQ 1477
                                   .||..|:.||  :|| .:||::.....:::.:|       ..
 Worm  1125 -----------------------QESIFNMTDK--DLSAFDTSEIFRPSTESVSRG-------TG 1157

  Fly  1478 NNAAAAAAAAAAAEEQISVRSSMKSTVSLTDAA----HLY---HNHLLIY--------LAIYDTR 1527
            ..||||||||.|:.:...:..::.|..|.:.||    .|:   |.|:|:|        ||..:|.
 Worm  1158 AGAAAAAAAAGASSKDTILPGTVSSASSTSSAAGGTSSLFEEMHTHMLLYGESGKVVDLARAETA 1222

  Fly  1528 -QTLYALQTLRNIICCDKRTFL-CL----SITTSFSSA--SLKQLLVRHRKSISGKGFDGSVGNS 1584
             :.|.||...|.  ....|..| ||    :.|||.|||  ||.:|:.||.::|.|:.|..:..:.
 Worm  1223 FRILTALLAPRG--ATGNRMLLNCLVSSGTTTTSDSSAEHSLVELMNRHVRAILGQHFWSAPASD 1285

  Fly  1585 EYAQGYRGCMQLELLVTLCLFYARGYFQKESLDAQRQSP-TLQDIVNNRRIQLESIELLTLICSE 1648
            |  :.::....||||:|:.|.:.|.||....:     || |..|:.:..:.::.::|.|..:..|
 Worm  1286 E--EKHKHITLLELLITISLHFLRSYFLNSPI-----SPVTEADLTSLWKCKISALEFLCELFRE 1343

  Fly  1649 LIEIV-KGMGRGLANYIADLLARAKLQKVMLHCLNSSV------CSYGLKGNTNSGSYAEQVLSF 1706
            |..:: :...:....::..:|.|:||||.:||.|.::|      .|...|.....|..:..:..|
 Worm  1344 LSAMLNEHESKQFVQFVQTILNRSKLQKCILHLLLTAVDHNPMESSSSKKTGGGGGPLSVSISKF 1408

  Fly  1707 ND---PQDDQLH--ADCFQLQLLRLLLAVIRLEHEVHQ-----------LRQDTPPAAGEDSAGN 1755
            |:   .:..:|.  ...:...||......||||.::.:           .|.....:....|..|
 Worm  1409 NEGLLGESRRLSPLLAAYHRSLLTFTSHAIRLECDIKRGFATFSDANSSHRFSIIQSVMNQSFNN 1473

  Fly  1756 ASPTRLAEGATANVKYLPNCLISQQPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGSLT 1820
            .:.......:|..::           .||..:|.||:::  .|.|..|...|...|.... .||.
 Worm  1474 RTSRVDNHASTVELR-----------AFLLILLNALKKQ--PHRHEMWLQFVVQILPWVE-RSLA 1524

  Fly  1821 NIVISVVHQLCSNLDRISKMGL-----------------PQQRHFPPDYVVSQLEALTILCHYCL 1868
            .||..||.|||.|::....:..                 .:...:|.:|:...:|.||.|.|:|:
 Worm  1525 TIVCRVVEQLCKNMENAMSVAYENPPTSDVVVDSPGDVRDEPDCYPANYLAMTMELLTTLVHFCV 1589

  Fly  1869 LDNTQQTALSHLFNQAYPQTSSSAQSSSTGQLLNSIVHSFLSASESSTS--------APAPR--- 1922
            :|:...:|::    ...|....:...:|:...:..::|...:.:.||||        .|..:
 Worm  1590 IDSVPTSAVA----GGAPGVGGAGGVTSSSGGVQQVIHENATPTPSSTSMVGHAMSVIPGSKVAT 1650

  Fly  1923 --NPQL---------------------------QAARNAVLSHLPRIMSSVAAIWD--------- 1949
              ..||                           :.|::.:||.||..::::..:|.
 Worm  1651 ELFSQLGKVFSMSGDSGGVISKLDSSRQHGNGWRQAQSDMLSSLPHSLATICNVWTVVRRAQPPI 1715

  Fly  1950 SELGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACPA 2014
            ..:|....:|:.:|..|||::.:|...||.::|:.|..|  :|....:::.:|....:..:...|
 Worm  1716 VPIGTNSQLRRLVLHLLSPIAQYHKHAFLTSLALVWLTR--STAKPTVTLRKQDPDRATFEYSSA 1778

  Fly  2015 QLSLVSLVSSIRVMPMDSFVMTLHHVVRSP---------PPIHRPPAQLSIEVSALELFYFYMKS 2070
            ||.:.:|:.|::|:|.:..:.:::..:|..         ..|.:  |....|...|||.:..:.:
 Worm  1779 QLDITNLLLSLQVIPFEDLISSVNSTLREASFKANKVGITTIDK--ANFPTEEPLLELVHSCVSA 1841

  Fly  2071 APAPQLADAWSSLLALIRDG--LNLTPPAQFALLMLLNEFVQRCPQMPF--QDKKEVRELHDVTS 2131
            ....||...|||||:|..:.  ..|:..|.|.|.::|::|| :|....:  :||...|.:.:|.|
 Worm  1842 VLQTQLRLCWSSLLSLFSEAPLSALSARAVFLLFVILSDFV-KCVGGAYIVEDKAMYRNVQEVCS 1905

  Fly  2132 RLVDSLSSVAGSCLEQTTWLRRNLAVKEDTDGLAKDNSV--------------------GGGGLQ 2176
            ||.::::::.|..||.||||:|.|.||:| .|.:..:|:                    |||.|.
 Worm  1906 RLAEAVNAIVGWQLETTTWLKRTLVVKQD-HGSSISSSIRSVDQSPIIEIQSSMSNVSGGGGSLD 1969

  Fly  2177 Q---------------------------------------------------------------Y 2178
            .                                                               :
 Worm  1970 NPSGSTRNSTLSLINKPGGSIGTGSSVTSTLVDSKSENMKIEKKSSSNLRASIKDTNNNRRDPAH 2034

  Fly  2179 SLQAQSVLAAILSNLLDVAYGSQEKDKVVNIVTPLLYNITPYLKNHTARNVPFFYACSALLASLS 2243
            |.||..:||..|::|||....|.|||||:..:..:..|:.||||...|||..||.|.|.||||:|
 Worm  2035 STQALFLLAERLTDLLDSVSKSDEKDKVLPTLQAVWANVVPYLKAKNARNARFFLASSQLLASMS 2099

  Fly  2244 GYQYTRKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNI 2308
            .|.|.|..|:|..||||||:.||:|..|.|..|.::.|.|||:|.|:|::|:..:|.|...|.:|
 Worm  2100 SYSYMRPVWKKTTLDLLLDSGFFKMDHSALKQWLVVTDHLMTHDRTSFKDLLKSISYSPNTSFSI 2164

  Fly  2309 FTSRDQEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVL 2373
            .||::||||.||..||||.||::.|:.||::..|.||||:|:::|| |...|.:::|||||.|||
 Worm  2165 MTSKEQEYEARAQALKRLTFVVFGSQLDQYHGQMNDIQERLSDNLR-VSQSPVIRSAVFLCIRVL 2228

  Fly  2374 LLRMSPDHVTSLWPIIIAEMVQVFLQMEQELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQ 2438
            |||:.|..:..:|||::.|:|....|:||:|:|..::               |.|:.||:
 Worm  2229 LLRLRPHSLIGVWPIMVTELVHALSQLEQQLQSGEQD---------------SGATAASS----- 2273

  Fly  2439 TPMQHWRSVQLEACKLLELGCVLPATKLPHFQMYRWAFVGTEFDVHEEEVCLPNGSLENLATLPS 2503
               ..|..:.:.||||||..|.|||..|.||||:.||||                  .:::...:
 Worm  2274 ---DQWMQLYVAACKLLETLCTLPAGYLSHFQMFHWAFV------------------SSVSADKT 2317

  Fly  2504 ALYVPHVRRVARLMDMKYTSQSPILQRP---SNRHLML-HFQQLQSLQELYAFFTT---LGISCP 2561
            .::.|...|:..|:..||..    |..|   ||....| ..:.|.|.:||..||.|   |..|.|
 Worm  2318 EIFKPFAERINDLLAKKYGE----LLTPETMSNHTASLGAVKILTSFEELRPFFYTLANLNKSVP 2378

  Fly  2562 QPRNFADTENDV---------ANCLKEIEEVLANDFLEKL 2592
            :..|   |..|.         .|.:..:|..|..||.|.|
 Worm  2379 ESNN---TLRDAHALSGSLTYKNAVARLESALYVDFSEHL 2415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15099	NP_001261081.1	Dopey_N	18..304	CDD:282036	135/295 (46%)
		Dopey_N	<2200..2477	CDD:296427	123/276 (45%)
pad-1	NP_493252.3	Dopey_N	18..300	CDD:282036	134/281 (48%)
		Dopey_N	<2053..2373	CDD:296427	142/365 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167547
Domainoid	1	1.000	267	1.000	Domainoid score	I998
eggNOG	1	0.900	-	-		E1_COG5221
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I664
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46621
OrthoDB	1	1.010	-	-		D29961at2759
OrthoFinder	1	1.000	-	-		FOG0003065
OrthoInspector	1	1.000	-	-		oto19924
orthoMCL	1	0.900	-	-		OOG6_102162
Panther	1	1.100	-	-	LDO	PTHR14042
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R332
SonicParanoid	1	1.000	-	-		X2429
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.890