Protein Alignment CG15097 and KEAP1

DIOPT Version :10

• Sequence 1: NP_001261079.1
• Gene: CG15097 / 37172
• FlyBaseID: FBgn0034396
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_036421.2
• Gene: KEAP1 / 9817
• HGNCID: 23177
• Length: 624
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 205/619 - (33%)
• Similarity: 311/619 - (50%)
• Gaps: 45/619 - (7%)

  Fly     2 FLPVKSNHSGEASGNNEDVTTTSNNSTQTPSDLSPPGPNEEVLPQAHHQN-------PGHCIASF 59
            |||::| ...|.:|:.....:|...:..|||               .|.|       ..|...:|
Human    16 FLPLQS-QCPEGAGDAVMYASTECKAEVTPS---------------QHGNRTFSYTLEDHTKQAF 64

  Fly    60 AAINQMRNNAQLCDVRLEV-----GGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVD 119
            ..:|::|.:.|||||.|:|     ......||:|||||.||.|.|||.:.:.|:...:|.:..:.
Human    65 GIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIH 129

  Fly   120 SSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAH 184
            ...:.:||::.||..|::.|:.|..::..:.:.|:.||..||..||::||.|||.:||.:||:..
Human   130 PKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194

  Fly   185 SCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPT 249
            .|.|||.|:.:|...:|.:|...|||..|...::..|||...||:..|..||.|.|||||:|...
Human   195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQ 259

  Fly   250 RRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQE 314
            ||.::..|:..||...::.:||...::...:::.||.||:.|::..:...|.:...:|..:..:.
Human   260 RRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKV 324

  Fly   315 RRPEGMKPYVFAVGG---GSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGG 376
            .|      .::..||   .||    :..|.|||...:|..:|.:...||......:...||.|||
Human   325 GR------LIYTAGGYFRQSL----SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG 379

  Fly   377 Y----DGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYD 437
            .    ||.:|.:..:.|||:||:||...||...|:.:|:...|..||..||..|....:|:|||:
Human   380 RNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYE 444

  Fly   438 PLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSS 502
            |....|.....|.|||....:|||...:|::||||.||..:|.|.:.|....|:.:.:|:..||.
Human   445 PERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSG 509

  Fly   503 CGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDG 567
            .||......:|..||.||...::|.||:.:...:|..:|.|..|||...:...:|.::.|||.||
Human   510 AGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDG 574

  Fly   568 SSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAV 601
            .:.|:|||.||...:.||.|..|.:.||.||.||
Human   575 HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB_POZ	51..171	CDD:453885	43/131 (33%)
		PHA03098	65..539	CDD:222983	163/485 (34%)
		BACK	169..282	CDD:475122	42/112 (38%)
		KELCH repeat	359..402	CDD:276965	17/46 (37%)
		KELCH repeat	406..450	CDD:276965	14/43 (33%)
		KELCH repeat	453..496	CDD:276965	15/42 (36%)
		KELCH repeat	500..545	CDD:276965	15/44 (34%)
		KELCH repeat	547..590	CDD:276965	17/42 (40%)
		Kelch	559..603	CDD:128874	21/43 (49%)
KEAP1	NP_036421.2	BTB_POZ_KLHL19_KEAP1	56..180	CDD:349557	41/123 (33%)
		PHA03098	95..596	CDD:222983	175/510 (34%)
		Kelch 1	327..372		12/48 (25%)
		KELCH repeat	362..409	CDD:276965	17/46 (37%)
		Kelch 2	373..423		19/49 (39%)
		KELCH repeat	413..456	CDD:276965	14/42 (33%)
		Kelch 3	424..470		18/45 (40%)
		KELCH repeat	460..503	CDD:276965	15/42 (36%)
		Kelch 4	471..517		16/45 (36%)
		KELCH repeat	507..551	CDD:276965	14/43 (33%)
		Kelch 5	518..564		14/45 (31%)
		KELCH repeat	554..597	CDD:276965	17/42 (40%)
		Kelch 6	565..611		21/44 (48%)