DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15097 and Klhl1

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_444335.2	Gene:	Klhl1 / 93688	MGIID:	2136335	Length:	751	Species:	Mus musculus

Alignment Length:	600	Identity:	229/600 - (38%)
Similarity:	344/600 - (57%)	Gaps:	22/600 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SGEASGNNEDVTTTSNNSTQTP-SDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCD 73
            :||..|:.    .||.|.:.|| |||. ...:||.....||..     .||..:.......||||
Mouse   162 TGEGCGHR----LTSTNHSLTPQSDLD-SSSSEEFYQAVHHAE-----QSFRKMENYLKQQQLCD 216

  Fly    74 VRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITIT 138
            |.|.||...|.|||:||:|||.||.|||..|:.|..|..:::..:|.:||..|:.:.|||.:.:.
Mouse   217 VILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELK 281

  Fly   139 EQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQ 203
            |..::.||.|:.|||:..|.:.||.||::.||||||||||:||||..|.||...:|.|.::|..:
Mouse   282 EDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIME 346

  Fly   204 VVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSR 268
            |:..:||||||.||:.:|:::..:|:..||.:|.|::.|||:|:..|...::.|::.:||||:..
Mouse   347 VIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLPLLPP 411

  Fly   269 DFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLF 333
            ..|.. :|...|.::|.||::|:|||||||||||:|::|.|.||:.|:  .....::||||....
Mouse   412 QILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRK--STVGTLYAVGGMDNN 473

  Fly   334 AIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSN 398
            ......|.|:.|:|.|.....|..||.:.||..:..:|:|:||.||:..|.|.|.|||.|..|:.
Mouse   474 KGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 538

  Fly   399 ITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLEN 463
            :.||.|.|..||:...:..||..||:||.|.|:::||:||.:..|:...:||..|....:|.|..
Mouse   539 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNG 603

  Fly   464 CIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDG------TM 522
            .:||:||.|.::..||:|.:||...:|.....|..||...|||:.||.||.:||:|.      :.
Mouse   604 KLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSR 668

  Fly   523 CMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVV 587
            .:...||:..:.::|..:|.:...|....|..:...|:|:||.||.:.||::|.||.:.|:|:.:
Mouse   669 LLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQM 733

  Fly   588 NAMVARRSSVGAAVL 602
            .::...|:  ||.|:
Mouse   734 ASLNIGRA--GACVV 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	43/102 (42%)
		PHA03098	65..539	CDD:222983	192/479 (40%)
		BACK	174..276	CDD:285009	41/101 (41%)
		Kelch	324..369	CDD:128874	14/44 (32%)
		KELCH repeat	359..402	CDD:276965	17/42 (40%)
		Kelch	370..415	CDD:128874	20/44 (45%)
		KELCH repeat	406..450	CDD:276965	16/43 (37%)
		Kelch	417..463	CDD:128874	18/45 (40%)
		KELCH repeat	453..496	CDD:276965	14/42 (33%)
		Kelch	464..510	CDD:128874	17/45 (38%)
		Kelch_1	499..543	CDD:279660	16/49 (33%)
		KELCH repeat	500..545	CDD:276965	15/50 (30%)
		KELCH repeat	547..590	CDD:276965	15/42 (36%)
		Kelch	559..603	CDD:128874	17/43 (40%)
Klhl1	NP_444335.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..98
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..184		10/25 (40%)
		BTB	205..308	CDD:279045	42/102 (41%)
		PHA03098	209..731	CDD:222983	207/524 (40%)
		BACK	317..416	CDD:285009	41/98 (42%)
		Kelch 1	463..509		14/45 (31%)
		Kelch	464..509	CDD:128874	14/44 (32%)
		Kelch_1	498..543	CDD:279660	19/44 (43%)
		KELCH repeat	499..542	CDD:276965	17/42 (40%)
		Kelch 2	510..556		20/45 (44%)
		KELCH repeat	546..590	CDD:276965	16/43 (37%)
		Kelch	558..603	CDD:128874	18/44 (41%)
		Kelch 3	558..603		18/44 (41%)
		KELCH repeat	593..636	CDD:276965	14/42 (33%)
		Kelch	604..650	CDD:128874	17/45 (38%)
		Kelch 4	604..650		17/45 (38%)
		KELCH repeat	640..690	CDD:276965	15/49 (31%)
		Kelch	652..703	CDD:128874	11/50 (22%)
		Kelch 5	652..703		11/50 (22%)
		KELCH repeat	693..737	CDD:276965	15/43 (35%)
		Kelch 6	704..750		17/44 (39%)
		Kelch	704..748	CDD:128874	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820