Protein Alignment CG15097 and Klhl1

DIOPT Version :10

• Sequence 1: NP_001261079.1
• Gene: CG15097 / 37172
• FlyBaseID: FBgn0034396
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_444335.2
• Gene: Klhl1 / 93688
• MGIID: 2136335
• Length: 751
• Species: Mus musculus
• Alignment Length: 600
• Identity: 229/600 - (38%)
• Similarity: 344/600 - (57%)
• Gaps: 22/600 - (3%)

  Fly    10 SGEASGNNEDVTTTSNNSTQTP-SDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCD 73
            :||..|:.    .||.|.:.|| |||. ...:||.....||..     .||..:.......||||
Mouse   162 TGEGCGHR----LTSTNHSLTPQSDLD-SSSSEEFYQAVHHAE-----QSFRKMENYLKQQQLCD 216

  Fly    74 VRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITIT 138
            |.|.||...|.|||:||:|||.||.|||..|:.|..|..:::..:|.:||..|:.:.|||.:.:.
Mouse   217 VILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELK 281

  Fly   139 EQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQ 203
            |..::.||.|:.|||:..|.:.||.||::.||||||||||:||||..|.||...:|.|.::|..:
Mouse   282 EDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIME 346

  Fly   204 VVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSR 268
            |:..:||||||.||:.:|:::..:|:..||.:|.|::.|||:|:..|...::.|::.:||||:..
Mouse   347 VIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLPLLPP 411

  Fly   269 DFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLF 333
            ..|.. :|...|.::|.||::|:|||||||||||:|::|.|.||:.|:  .....::||||....
Mouse   412 QILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRK--STVGTLYAVGGMDNN 473

  Fly   334 AIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSN 398
            ......|.|:.|:|.|.....|..||.:.||..:..:|:|:||.||:..|.|.|.|||.|..|:.
Mouse   474 KGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 538

  Fly   399 ITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLEN 463
            :.||.|.|..||:...:..||..||:||.|.|:::||:||.:..|:...:||..|....:|.|..
Mouse   539 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNG 603

  Fly   464 CIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDG------TM 522
            .:||:||.|.::..||:|.:||...:|.....|..||...|||:.||.||.:||:|.      :.
Mouse   604 KLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSR 668

  Fly   523 CMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVV 587
            .:...||:..:.::|..:|.:...|....|..:...|:|:||.||.:.||::|.||.:.|:|:.:
Mouse   669 LLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQM 733

  Fly   588 NAMVARRSSVGAAVL 602
            .::...|:  ||.|:
Mouse   734 ASLNIGRA--GACVV 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB_POZ	51..171	CDD:453885	47/119 (39%)
		PHA03098	65..539	CDD:222983	192/479 (40%)
		BACK	169..282	CDD:475122	48/112 (43%)
		KELCH repeat	359..402	CDD:276965	17/42 (40%)
		KELCH repeat	406..450	CDD:276965	16/43 (37%)
		KELCH repeat	453..496	CDD:276965	14/42 (33%)
		KELCH repeat	500..545	CDD:276965	15/50 (30%)
		KELCH repeat	547..590	CDD:276965	15/42 (36%)
		Kelch	559..603	CDD:128874	17/43 (40%)
Klhl1	NP_444335.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..54
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..98
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..184		10/25 (40%)
		PHA03098	209..731	CDD:222983	207/524 (40%)
		Kelch 1	463..509		14/45 (31%)
		KELCH repeat	499..542	CDD:276965	17/42 (40%)
		Kelch 2	510..556		20/45 (44%)
		KELCH repeat	546..590	CDD:276965	16/43 (37%)
		Kelch 3	558..603		18/44 (41%)
		KELCH repeat	593..636	CDD:276965	14/42 (33%)
		Kelch 4	604..650		17/45 (38%)
		KELCH repeat	640..690	CDD:276965	15/49 (31%)
		Kelch 5	652..703		11/50 (22%)
		KELCH repeat	693..737	CDD:276965	15/43 (35%)
		Kelch 6	704..750		17/44 (39%)