Protein Alignment CG15097 and GAN

DIOPT Version :10

• Sequence 1: NP_001261079.1
• Gene: CG15097 / 37172
• FlyBaseID: FBgn0034396
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_071324.1
• Gene: GAN / 8139
• HGNCID: 4137
• Length: 597
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 162/615 - (26%)
• Similarity: 271/615 - (44%)
• Gaps: 88/615 - (14%)

  Fly    51 NPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFN-----DDMLERTQ 110
            :|.|......|::..|..::.||..|.:.|:.|...:.:||:.|||.....|     ||   .:.
Human     9 DPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDD---GST 70

  Fly   111 GLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCL 175
            ..:.|..:....:|:::||.::|:|.:.|..:|.::.|:.||.:..::..||:||...:...||:
Human    71 YKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCI 135

  Fly   176 GIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVI 240
            |||.||..:....:|..:.:|...:|:.|..|||||.|..::::|:||..:||:.:|..||.|||
Human   136 GIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVI 200

  Fly   241 NWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRD-DSECKELLLEAMKYHLLPEQR 304
            .|:.||...|::|:.::||.:.:..:...:|...:..|.|:|: ..||..:.|..      |:|
Human   201 RWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQ------PQQ- 258

  Fly   305 SIMGSQRTQERRPEGMKPYVFAVGGGS------LFAIHNECEVYNPRSNSWSPVAPMLWRRSRSG 363
               |.......:|.|....:..|||..      ..|:...|.:|:|....|..:||:...|...|
Human   259 ---GEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHG 320

  Fly   364 VTSLHKQLYVVGGYD-GVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGA 427
            |.|....|:|.||.| ....|::.|.|:|..|.|:.:.||...|...||...|.::|:.||.||.
Human   321 VLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGE 385

  Fly   428 SCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQP 492
            ..|.|||.||..:..|:..|.::..|:....|.::..||::||........|||.:|||..:|..
Human   386 KELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTA 450

  Fly   493 VPSMSARR---SSCGVASTDGHLYCIGG------------------------------NDGTMCM 524
            :..:..||   .:||||.   .||..||                              ||..:|:
Human   451 ICPLKERRFGAVACGVAM---ELYVFGGVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCI 512

  Fly   525 SSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNA 589
            .:...|                  .:..|.:..:::.:|..|..::.:.|..:......|.....
Human   513 PASSSF------------------VYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKP 559

  Fly   590 MV---ARRSSVGA-AVLEC----FHLERGL 611
            ::   .||:...| .:..|    ..|::||
Human   560 LLPSDLRRTGCAALRIANCKLFRLQLQQGL 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB_POZ	51..171	CDD:453885	32/124 (26%)
		PHA03098	65..539	CDD:222983	147/519 (28%)
		BACK	169..282	CDD:475122	38/112 (34%)
		KELCH repeat	359..402	CDD:276965	15/43 (35%)
		KELCH repeat	406..450	CDD:276965	17/43 (40%)
		KELCH repeat	453..496	CDD:276965	13/42 (31%)
		KELCH repeat	500..545	CDD:276965	13/77 (17%)
		KELCH repeat	547..590	CDD:276965	5/42 (12%)
		Kelch	559..603	CDD:128874	7/47 (15%)
GAN	NP_071324.1	BTB_POZ_KLHL16_gigaxonin	16..126	CDD:349554	29/112 (26%)
		PHA03098	27..502	CDD:222983	142/490 (29%)
		BACK_KLHL16_gigaxonin	130..226	CDD:350530	35/95 (37%)
		Kelch 1	274..326		14/51 (27%)
		KELCH repeat	316..360	CDD:276965	15/43 (35%)
		Kelch 2	327..374		16/46 (35%)
		KELCH repeat	364..408	CDD:276965	17/43 (40%)
		Kelch 3	376..421		15/44 (34%)
		KELCH repeat	411..456	CDD:276965	13/44 (30%)
		Kelch 4	422..468		16/45 (36%)
		KELCH repeat	458..511	CDD:276965	11/55 (20%)
		Kelch 5	470..522		8/69 (12%)
		KELCH repeat	514..561	CDD:276965	6/64 (9%)
		Kelch 6	528..574		7/45 (16%)