DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and Klhl5

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_780383.2	Gene:	Klhl5 / 71778	MGIID:	1919028	Length:	708	Species:	Mus musculus

Alignment Length:	608	Identity:	243/608 - (39%)
Similarity:	357/608 - (58%)	Gaps:	20/608 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PVKSNHSGEASGNNEDVTTTSNNSTQTPSD---LSPPGPNEEVLPQAHHQNPGHCIASFAAINQM 65
            |...:.:.|....::..::.::||:||.|.   :.|...:|      ..|...|...:|..:...
Mouse   108 PEVDDGTSEEENESDSSSSRTSNSSQTLSSCQAMEPCSSDE------FFQALNHAEQTFKKMENY 166

  Fly    66 RNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYT 130
            ..:.|||||.|..|...|.|||:||:|||.||.|||.:|:.|..|..:::..|:.::|..||.|.
Mouse   167 LRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 231

  Fly   131 YTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHK 195
            |||.:.:.|.|::.||..:.|||:..|.:||||||::||||||||||||||||..|.:||..:|.
Mouse   232 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHN 296

  Fly   196 YALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSN 260
            |.:::|.:|:..:||:|||..|:.:|:::..:||.:||.:..|::.||:|||..||..::.|::.
Mouse   297 YTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSRLLAY 361

  Fly   261 VRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVF 325
            :||||::..||.. :|...|.|||.||::|::||||||||||:|.::.|.||:.|:  .....:|
Mouse   362 IRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRK--STVGTLF 423

  Fly   326 AVGGGSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYN 390
            ||||..........|.|:.|:|.|:|||.|..||.:.||..|..:||||||.||:..|.|.|.||
Mouse   424 AVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYN 488

  Fly   391 PLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRY 455
            |.|..||.:.||.|.|..||:...:..:|..||:||.|.|:::||:||....|:....|||.|..
Mouse   489 PKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 553

  Fly   456 CRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDG 520
            ..:|||...:|::||.|.::...|||.|||...:|.....||.||...||.:.:|.||.|||:|.
Mouse   554 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDA 618

  Fly   521 -TMCMSSG-----ERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDT 579
             |..::|.     ||:..:.:.|..:|:|...|....|..:...|:|:||.||.:.||.||.||.
Mouse   619 PTSNLTSRLSDCVERYDPKTDVWTAVASMSVSRDAVGVCLLGDKLYAVGGYDGQTYLNIVEAYDP 683

  Fly   580 RLNKWSVVNAMVARRSSVGAAVL 602
            :.|:|:.|..:...|:  ||.|:
Mouse   684 QTNEWTQVAPLCLGRA--GACVV 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	45/102 (44%)
		PHA03098	65..539	CDD:222983	208/479 (43%)
		BACK	174..276	CDD:285009	43/101 (43%)
		Kelch	324..369	CDD:128874	19/44 (43%)
		KELCH repeat	359..402	CDD:276965	21/42 (50%)
		Kelch	370..415	CDD:128874	23/44 (52%)
		KELCH repeat	406..450	CDD:276965	15/43 (35%)
		Kelch	417..463	CDD:128874	19/45 (42%)
		KELCH repeat	453..496	CDD:276965	15/42 (36%)
		Kelch	464..510	CDD:128874	17/45 (38%)
		Kelch_1	499..543	CDD:279660	17/49 (35%)
		KELCH repeat	500..545	CDD:276965	17/50 (34%)
		KELCH repeat	547..590	CDD:276965	17/42 (40%)
		Kelch	559..603	CDD:128874	19/44 (43%)
Klhl5	NP_780383.2	BTB	163..266	CDD:279045	44/102 (43%)
		PHA03098	173..695	CDD:222983	225/524 (43%)
		BACK	275..374	CDD:285009	43/98 (44%)
		Kelch	422..467	CDD:128874	19/44 (43%)
		Kelch_1	456..501	CDD:279660	23/44 (52%)
		KELCH repeat	457..500	CDD:276965	21/42 (50%)
		KELCH repeat	504..548	CDD:276965	15/43 (35%)
		Kelch	517..561	CDD:128874	19/43 (44%)
		KELCH repeat	551..594	CDD:276965	15/42 (36%)
		Kelch	562..608	CDD:128874	17/45 (38%)
		Kelch_1	597..648	CDD:279660	17/50 (34%)
		KELCH repeat	598..648	CDD:276965	16/49 (33%)
		Kelch_1	651..694	CDD:279660	17/42 (40%)
		KELCH repeat	651..694	CDD:276965	17/42 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820