DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and KLHL8

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001278932.1	Gene:	KLHL8 / 57563	HGNCID:	18644	Length:	620	Species:	Homo sapiens

Alignment Length:	545	Identity:	206/545 - (37%)
Similarity:	311/545 - (57%)	Gaps:	14/545 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 NAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYT 132
            |.:||||.|:||...|:.|::|||.|.|||.|||..:|.|..|.|:.:.|.|..|:..|:.:.|:
Human    63 NGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYS 127

  Fly   133 GEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYA 197
            ..:|:|..|||.||.|:.:||:..|..|||:::....||||||.:|:||::|:..:|...:.:||
Human   128 SRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYA 192

  Fly   198 LQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVR 262
            ..:|.:||..|:|:.:..:.:.:|:|:|.|||.:|::|:.|.|.|:..:.......:.|.::.||
Human   193 CDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVR 257

  Fly   263 LPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMG---SQRTQERR-PEGMKPY 323
            |||:..||||..|..|.:::.:.:|::||.||..|||....|::..   |.||..|: ..|:
Human   258 LPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGV--- 319

  Fly   324 VFAVGG----GSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLA 384
            :|.|||    |..|   ...|.|:...|||.....|..||...||.|:..::|.|||:||...|.
Human   320 LFCVGGRGGSGDPF---RSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLG 381

  Fly   385 TAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAM 449
            :.|.::||||||.....|.|||..:.:.|....||..||.|..:|.:.:||||..:..||:...|
Human   382 SMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPM 446

  Fly   450 STRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYC 514
            :|.|.......|.|.:|::||.|.....|||||:||.:.:|..|..|..||:..||:...|.||.
Human   447 NTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYV 511

  Fly   515 IGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDT 579
            :||.|....:||.||:..|.|.|:.:||:.:.|....:..|.|.:||:||::|::.||:||.:|.
Human   512 VGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDP 576

  Fly   580 RLNKWSVVNAMVARRSSVGAAVLEC 604
            .||:|.:|.::...|:..|.||..|
Human   577 VLNRWELVGSVSHCRAGAGVAVCSC 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	43/97 (44%)
		PHA03098	65..539	CDD:222983	182/478 (38%)
		BACK	174..276	CDD:285009	35/101 (35%)
		Kelch	324..369	CDD:128874	17/48 (35%)
		KELCH repeat	359..402	CDD:276965	18/42 (43%)
		Kelch	370..415	CDD:128874	19/44 (43%)
		KELCH repeat	406..450	CDD:276965	14/43 (33%)
		Kelch	417..463	CDD:128874	16/45 (36%)
		KELCH repeat	453..496	CDD:276965	16/42 (38%)
		Kelch	464..510	CDD:128874	18/45 (40%)
		Kelch_1	499..543	CDD:279660	18/43 (42%)
		KELCH repeat	500..545	CDD:276965	18/44 (41%)
		KELCH repeat	547..590	CDD:276965	17/42 (40%)
		Kelch	559..603	CDD:128874	18/43 (42%)
KLHL8	NP_001278932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		BTB	57..161	CDD:279045	43/97 (44%)
		PHA03098	60..535	CDD:222983	181/477 (38%)
		BACK	169..271	CDD:285009	35/101 (35%)
		Kelch	319..366	CDD:128874	17/52 (33%)
		Kelch 1	319..366		17/52 (33%)
		KELCH repeat	356..399	CDD:276965	18/42 (43%)
		Kelch	367..413	CDD:128874	19/45 (42%)
		Kelch 2	367..413		19/45 (42%)
		KELCH repeat	403..447	CDD:276965	14/43 (33%)
		Kelch 3	415..460		16/44 (36%)
		Kelch	415..458	CDD:128874	15/42 (36%)
		KELCH repeat	450..495	CDD:276965	17/44 (39%)
		Kelch	461..502	CDD:128874	16/40 (40%)
		Kelch 4	462..507		18/44 (41%)
		KELCH repeat	497..542	CDD:276965	18/44 (41%)
		Kelch	508..554	CDD:128874	16/45 (36%)
		Kelch 5	508..554		16/45 (36%)
		KELCH repeat	544..586	CDD:276965	17/41 (41%)
		Kelch	555..599	CDD:128874	17/43 (40%)
		Kelch 6	556..601		18/44 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820