DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and klhl8

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001103950.1	Gene:	klhl8 / 572347	ZFINID:	ZDB-GENE-070209-226	Length:	604	Species:	Danio rerio

Alignment Length:	549	Identity:	202/549 - (36%)
Similarity:	311/549 - (56%)	Gaps:	14/549 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 AINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQ 125
            ::.|...|.:||||.|:||...|..|::|||.|.|||.|||..||.|..|.|:.:.|.|:.|::.
Zfish    40 SLRQFYENGELCDVTLKVGNRLIPCHKLVLACVVPYFRAMFLSDMAEAKQDLIEIRDFDADAIQD 104

  Fly   126 LIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELH 190
            |:.:.|:..:|:|..|||.||.|:.:||:..:..|||:::....||||||.:|:||::|:..:|.
Zfish   105 LVRFAYSSRLTLTVDNVQPLLYAACILQVELIARACCEYMKAHFHPSNCLAVRTFAESHNRVDLM 169

  Fly   191 TRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIA 255
            ..:.:||.::|.|||..|:|:.:..:.::.|:::|.|||.:|.:|:.|.:.|::.:.....:.:.
Zfish   170 DMADRYACEHFSQVVECEDFVCVSPQHLKTLLASSDLNIQAETQVYNAAVKWLRANQKHHAVWLD 234

  Fly   256 ELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQ---RTQERR- 316
            ::|:.|||||:..:||.:.|..|.:::....|::||.||..|||....:|:...|   ||..|:
Zfish   235 QIMAQVRLPLLPVEFLTATVAKEEMIKASLSCRDLLDEARNYHLHLSNKSVPDFQYSVRTTARKH 299

  Fly   317 PEGMKPYVFAVGG----GSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGY 377
            ..|:   :|.|||    |..|   ...|.|:...|||.....|..||...||.|:..::|.|||:
Zfish   300 TAGV---LFCVGGRGGSGDPF---RSIECYSISKNSWFFGPEMNSRRRHVGVISVAGKVYAVGGH 358

  Fly   378 DGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGI 442
            ||...|.:.|.::|.||||.....|.|||..:.:.:....:|..||.|..||.|.:||||.....
Zfish   359 DGNEHLGSMEMFDPHTNKWMMRASMNTKRRGIALAALGGPLYAIGGLDDNSCFSDVERYDIECDR 423

  Fly   443 WSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVAS 507
            ||:..||:|.|.......|...:|::||.|.....||||||||.:.:|..|..|..||:..||:.
Zfish   424 WSAVAAMNTPRGGVGSVALGGFVYAVGGNDGVASLSSVERFDPHLNKWTEVREMGQRRAGNGVSE 488

  Fly   508 TDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLN 572
            ..|.||.:||.|....:||.|||..|.|.|:.:..:.:.|....|..|.|.:||:||::|:..||
Zfish   489 LHGCLYVVGGFDDNSPLSSVERFDPRLNRWDYVCELTTPRGGVGVATVMGRVFAVGGHNGNIYLN 553

  Fly   573 SVERYDTRLNKWSVVNAMVARRSSVGAAV 601
            :||.::.|:|:|.:|.::...|:..|.||
Zfish   554 TVEAFEPRMNRWELVGSVSHCRAGAGVAV 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	44/102 (43%)
		PHA03098	65..539	CDD:222983	180/481 (37%)
		BACK	174..276	CDD:285009	32/101 (32%)
		Kelch	324..369	CDD:128874	17/48 (35%)
		KELCH repeat	359..402	CDD:276965	17/42 (40%)
		Kelch	370..415	CDD:128874	17/44 (39%)
		KELCH repeat	406..450	CDD:276965	15/43 (35%)
		Kelch	417..463	CDD:128874	18/45 (40%)
		KELCH repeat	453..496	CDD:276965	16/42 (38%)
		Kelch	464..510	CDD:128874	19/45 (42%)
		Kelch_1	499..543	CDD:279660	18/43 (42%)
		KELCH repeat	500..545	CDD:276965	17/44 (39%)
		KELCH repeat	547..590	CDD:276965	17/42 (40%)
		Kelch	559..603	CDD:128874	17/43 (40%)
klhl8	NP_001103950.1	BTB	41..145	CDD:279045	44/103 (43%)
		PHA03098	44..526	CDD:222983	180/487 (37%)
		BACK	153..255	CDD:285009	32/101 (32%)
		Kelch	303..350	CDD:128874	17/52 (33%)
		KELCH repeat	340..383	CDD:276965	17/42 (40%)
		Kelch	351..397	CDD:128874	17/45 (38%)
		KELCH repeat	387..431	CDD:276965	15/43 (35%)
		Kelch	399..444	CDD:128874	18/44 (41%)
		Kelch_1	433..478	CDD:279660	16/44 (36%)
		KELCH repeat	434..479	CDD:276965	17/44 (39%)
		KELCH repeat	481..525	CDD:276965	17/43 (40%)
		Kelch	492..538	CDD:128874	16/45 (36%)
		KELCH repeat	528..570	CDD:276965	17/41 (41%)
		Kelch	539..583	CDD:128874	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920