DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and klhl3

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_009289334.1	Gene:	klhl3 / 568556	ZFINID:	ZDB-GENE-120203-4	Length:	593	Species:	Danio rerio

Alignment Length:	577	Identity:	241/577 - (41%)
Similarity:	349/577 - (60%)	Gaps:	15/577 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 STQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLA 91
            |..:..|...||        .|..:..|...:|..:|.:|:...||||.|..|...|.|||||||
Zfish    14 SLDSQDDAKDPG--------LHTFSHTHMRKAFLLMNDLRSRKMLCDVLLVAGEVEIPAHRVVLA 70

  Fly    92 SVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHS 156
            |.||||.|||..||.|.....|.:.|||...|.:|:||.|:.||.::|:||||||||:.|||:..
Zfish    71 SCSPYFCAMFTGDMSESKANHVEIRDVDGQTLLKLVDYIYSAEIEVSEENVQVLLPAASLLQLMD 135

  Fly   157 VRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVREL 221
            ||..||.||..||||:||||||:|||.|:|..|.:::|.||.|:|..|:..|||:.|..::|..|
Zfish   136 VRQVCCDFLQTQLHPTNCLGIRAFADLHACTVLLSQAHAYAEQHFTDVMVGEEFMALSLQQVCSL 200

  Fly   222 ISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSE 286
            ||:.:|.:|:||:||.|::.|:|||...|..|:.:||.:|||||:|||:|:..||.|.|:::::.
Zfish   201 ISSDKLTVSTEEKVFEAMVAWIKHDKEARLEHMPKLMEHVRLPLLSRDYLVQIVEEEPLIKNNNT 265

  Fly   287 CKELLLEAMKYHLLP-EQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFAIHN-ECEVYNPRSNSW 349
            ||:.|:||||||||| :||.::.:.||:.|.|..:...:..|||.:..||.: ||  |:.:.:.|
Zfish   266 CKDFLIEAMKYHLLPADQRHLIKTDRTRPRTPISLPKVMMVVGGQAPKAIRSVEC--YDFQEDRW 328

  Fly   350 SPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSY 414
            ..||.:..||.|:||..:..::|.|||::|...:.|.:.|:.|.::||:|..|..:||.||....
Zfish   329 YQVADLPSRRCRAGVVYMAGKVYAVGGFNGSLRVRTVDVYDGLKDQWSSIPSMQERRSTLGAAVL 393

  Fly   415 DALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQ-- 477
            ..|:|..||:||::.|||:|.|:|....|.....|:|||....:.|::..:|::||:|..:.|
Zfish   394 GDLLYAVGGFDGSTGLSSVEAYNPKANEWMFVAPMNTRRSSVGVGVVDGKLYAVGGYDGASRQCL 458

  Fly   478 SSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAA 542
            |:||.|:|...:|..|..||.|||..||....|.||..||:||.:...|.|.:....|:|..:..
Zfish   459 STVEEFNPVSNKWCYVSDMSTRRSGAGVGVLSGQLYAAGGHDGPLVRKSVEVYDPTTNTWRQVCD 523

  Fly   543 MHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNAMVAR-RSSVG 598
            |:..|....|..:.|.|:.:||:|||.:|:|||.||...:|||::...::. ||..|
Zfish   524 MNMCRRNAGVCAINGLLYVIGGDDGSCNLSSVEYYDPAADKWSLIPTNMSNGRSYAG 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	55/102 (54%)
		PHA03098	65..539	CDD:222983	211/477 (44%)
		BACK	174..276	CDD:285009	49/101 (49%)
		Kelch	324..369	CDD:128874	16/45 (36%)
		KELCH repeat	359..402	CDD:276965	15/42 (36%)
		Kelch	370..415	CDD:128874	16/44 (36%)
		KELCH repeat	406..450	CDD:276965	17/43 (40%)
		Kelch	417..463	CDD:128874	18/45 (40%)
		KELCH repeat	453..496	CDD:276965	14/44 (32%)
		Kelch	464..510	CDD:128874	19/47 (40%)
		Kelch_1	499..543	CDD:279660	16/43 (37%)
		KELCH repeat	500..545	CDD:276965	16/44 (36%)
		KELCH repeat	547..590	CDD:276965	18/42 (43%)
		Kelch	559..603	CDD:128874	18/41 (44%)
klhl3	XP_009289334.1	PHA03098	51..567	CDD:222983	227/517 (44%)
		KELCH repeat	338..381	CDD:276965	15/42 (36%)
		KELCH repeat	385..428	CDD:276965	17/42 (40%)
		KELCH repeat	432..478	CDD:276965	14/45 (31%)
		KELCH repeat	481..526	CDD:276965	16/44 (36%)
		KELCH repeat	528..569	CDD:276965	18/40 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920