DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15097 and KLHL4

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_476503.1	Gene:	KLHL4 / 56062	HGNCID:	6355	Length:	720	Species:	Homo sapiens

Alignment Length:	581	Identity:	229/581 - (39%)
Similarity:	335/581 - (57%)	Gaps:	23/581 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ASGNNEDVTTTSNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDVRLE 77
            |..|.||  :|:...||...|::.....|    |.|..|  |...:...:.......|||||.|.
Human   131 ADDNIED--STARLDTQHSEDMNATRSEE----QFHVIN--HAEQTLRKMENYLKEKQLCDVLLI 187

  Fly    78 VGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNV 142
            .|...|.|||:||::||.||.|||.:|:||..|..||:..||.:||..|:.|.|||.:.:.|..:
Human   188 AGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTI 252

  Fly   143 QVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGT 207
            :.||.|:.|||:..|.|.|..||::|||||||||||||.||..|.||...:|||.:::|.:|:..
Human   253 ESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKN 317

  Fly   208 EEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLM 272
            :||||||..|:.:|:.:..:|:..||.:|.|::.||.||:..|:..:..|:|.:||||:... |:
Human   318 QEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LL 381

  Fly   273 SCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFAIHN 337
            :.:||.::...|.||::||:||||||||||:||:|.|.||:.|:  .....::||||........
Human   382 ADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTT 444

  Fly   338 ECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNITPM 402
            ..|.|:.|:|||..:..|..||.:.||..:..:||||||.||:..|.|.|.:||:...|:.:.||
Human   445 TIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPM 509

  Fly   403 GTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYS 467
            .|.|..||:.:.:..:|..||:||.|.|:::||:||....|:...:|||.|....:..|.|.:|:
Human   510 STHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYA 574

  Fly   468 LGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDG---------TMC 523
            :||.|.::...|:|.|||...:|.....||.||...|||:.:|.||.:||:|.         :.|
Human   575 IGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDC 639

  Fly   524 MSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKW 584
            :   ||:..:.:||..:|.:...|....|..:...|:.:||.||.:.||:||.||.:.|:|
Human   640 V---ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	46/102 (45%)
		PHA03098	65..539	CDD:222983	200/482 (41%)
		BACK	174..276	CDD:285009	42/101 (42%)
		Kelch	324..369	CDD:128874	15/44 (34%)
		KELCH repeat	359..402	CDD:276965	17/42 (40%)
		Kelch	370..415	CDD:128874	20/44 (45%)
		KELCH repeat	406..450	CDD:276965	15/43 (35%)
		Kelch	417..463	CDD:128874	17/45 (38%)
		KELCH repeat	453..496	CDD:276965	13/42 (31%)
		Kelch	464..510	CDD:128874	17/45 (38%)
		Kelch_1	499..543	CDD:279660	17/52 (33%)
		KELCH repeat	500..545	CDD:276965	16/53 (30%)
		KELCH repeat	547..590	CDD:276965	15/38 (39%)
		Kelch	559..603	CDD:128874	13/26 (50%)
KLHL4	NP_476503.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..69
		BTB	172..276	CDD:279045	46/103 (45%)
		PHA03098	176..698	CDD:222983	216/528 (41%)
		BACK	284..373	CDD:285009	37/88 (42%)
		Kelch 1	430..476		15/45 (33%)
		Kelch	431..476	CDD:128874	15/44 (34%)
		Kelch_1	465..510	CDD:279660	19/44 (43%)
		KELCH repeat	466..509	CDD:276965	17/42 (40%)
		Kelch 2	477..523		20/45 (44%)
		KELCH repeat	513..557	CDD:276965	15/43 (35%)
		Kelch 3	525..570		17/44 (39%)
		Kelch	526..570	CDD:128874	17/43 (40%)
		KELCH repeat	560..603	CDD:276965	13/42 (31%)
		Kelch	571..617	CDD:128874	17/45 (38%)
		Kelch 4	571..617		17/45 (38%)
		KELCH repeat	607..658	CDD:276965	16/53 (30%)
		Kelch	619..670	CDD:128874	13/53 (25%)
		Kelch 5	619..670		13/53 (25%)
		Kelch_1	659..702	CDD:279660	15/39 (38%)
		KELCH repeat	660..699	CDD:276965	15/38 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820