DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and klhl8

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001017289.1	Gene:	klhl8 / 550043	XenbaseID:	XB-GENE-995628	Length:	616	Species:	Xenopus tropicalis

Alignment Length:	544	Identity:	203/544 - (37%)
Similarity:	313/544 - (57%)	Gaps:	16/544 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGE 134
            :||||.|:||...|..|::|||.|.|||.|||..||.|..|.|:.:.|.|..|:..|:.::|:..
Frog    61 ELCDVTLKVGSKLIPCHKLVLACVIPYFRAMFLSDMAETKQTLIEIQDFDGDAIEDLVKFSYSSC 125

  Fly   135 ITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQ 199
            :|:|..|||.||.|:.:||:..|..|||:::....||||||.:|:||::|:..:|...:.:||..
Frog   126 VTLTVDNVQPLLYAACILQVELVAKACCEYMKLHFHPSNCLAVRAFAESHNRVDLMDMADRYACD 190

  Fly   200 NFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIA---ELMSNV 261
            :|.:||..::|:.:..:.:.:|:|:..|||.:|::|:.|.:.|: |..|  :.|.|   |::|.|
Frog   191 HFTEVVDCDDFVTMTPQHLYKLLSSGDLNIENEKQVYNAAMKWL-HANP--QYHTAWLDEILSQV 252

  Fly   262 RLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYV-F 325
            ||||:..:||||.|..|.:::.:.:|::||.||..|||....||:...:.|....|......| |
Frog   253 RLPLLPVEFLMSVVAKEDIIKQNLKCRDLLDEARNYHLYLSNRSLPDFEYTARTIPRKQTAGVLF 317

  Fly   326 AVGG----GSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATA 386
            .|||    |..|   ...|.|:...|||.....|..||...||.|:..::|.|||:||...|.:.
Frog   318 CVGGRGGSGDPF---RSIECYSVTKNSWFFGPEMNSRRRHVGVISVGGKVYAVGGHDGNEHLGSM 379

  Fly   387 ESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSS-CPAMS 450
            |.::||||||.....|.|||..:.:.|....||..||.|..:|.:.:||||..:..|:| .|.:|
Frog   380 ELFDPLTNKWMMKASMNTKRRGIALSSLGGPIYAIGGLDDNTCFNDVERYDIESDHWTSVAPMIS 444

  Fly   451 TRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCI 515
            .|.....:|::.: :|::||.|.....|||||:||.:.:|..|..|..||:..||:...|.||.:
Frog   445 PRGGVGSVALMSH-VYAVGGNDGVASLSSVERYDPHLDKWVEVKEMGQRRAGNGVSELHGCLYVV 508

  Fly   516 GGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTR 580
            ||.|....:||.||:..|.|.|:.::.:.:.|....:..:.|.::|:||::|::.||:||.||.|
Frog   509 GGFDDNSPLSSVERYDPRMNKWDYVSELTTPRGGVGIATLMGKIYAVGGHNGNAYLNTVESYDPR 573

  Fly   581 LNKWSVVNAMVARRSSVGAAVLEC 604
            :|:|.:|.::...|:..|.||..|
Frog   574 INRWELVGSVAHCRAGAGVAVCAC 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	43/95 (45%)
		PHA03098	65..539	CDD:222983	182/477 (38%)
		BACK	174..276	CDD:285009	37/104 (36%)
		Kelch	324..369	CDD:128874	18/49 (37%)
		KELCH repeat	359..402	CDD:276965	18/42 (43%)
		Kelch	370..415	CDD:128874	19/44 (43%)
		KELCH repeat	406..450	CDD:276965	15/44 (34%)
		Kelch	417..463	CDD:128874	16/46 (35%)
		KELCH repeat	453..496	CDD:276965	14/42 (33%)
		Kelch	464..510	CDD:128874	18/45 (40%)
		Kelch_1	499..543	CDD:279660	17/43 (40%)
		KELCH repeat	500..545	CDD:276965	16/44 (36%)
		KELCH repeat	547..590	CDD:276965	16/42 (38%)
		Kelch	559..603	CDD:128874	18/43 (42%)
klhl8	NP_001017289.1	BTB_POZ_KLHL8	48..167	CDD:349547	48/105 (46%)
		PHA03098	56..531	CDD:222983	181/476 (38%)
		KELCH repeat	352..395	CDD:276965	18/42 (43%)
		KELCH repeat	399..443	CDD:276965	15/43 (35%)
		KELCH repeat	446..491	CDD:276965	16/45 (36%)
		KELCH repeat	493..537	CDD:276965	16/43 (37%)
		KELCH repeat	540..582	CDD:276965	16/41 (39%)
		Kelch	551..595	CDD:128874	17/43 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920