DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and KLHL5

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_011512001.1	Gene:	KLHL5 / 51088	HGNCID:	6356	Length:	804	Species:	Homo sapiens

Alignment Length:	593	Identity:	238/593 - (40%)
Similarity:	348/593 - (58%)	Gaps:	18/593 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PVKSNHSGEASGNNEDVTTTSNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNN 68
            |...:.:.|....::..:..::||:||   ||.....|........|...|...:|..:.....:
Human   189 PEVDDGTSEEENESDSSSCRTSNSSQT---LSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRH 250

  Fly    69 AQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTG 133
            .|||||.|..|...|.|||:||:|||.||.|||.:|:.|..|..:::..|:.::|..||.|.|||
Human   251 KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 315

  Fly   134 EITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYAL 198
            .:.:.|.|::.||..:.|||:..|.:||||||::||||||||||||||||..|.:||..:|.|.:
Human   316 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 380

  Fly   199 QNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRL 263
            ::|.:|:..:||:|||..|:.:|:::..:||.:||.:..|::.||:|||..||..:::|::.:||
Human   381 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 445

  Fly   264 PLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVG 328
            ||::..||.. :|...|.|||.||::|::||||||||||:|.::.|.||:.|:  .....:||||
Human   446 PLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRK--STVGTLFAVG 507

  Fly   329 GGSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLT 393
            |..........|.|:.|:|.|:|||.|..||.:.||..|..:||||||.||:..|.|.|.|||.|
Human   508 GMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKT 572

  Fly   394 NKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRL 458
            ..||.:.||.|.|..||:...:..:|..||:||.|.|:::||:||....|:....|||.|....:
Human   573 KTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGV 637

  Fly   459 AVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDG--- 520
            |||...:|::||.|.::...|||.|||...:|.....||.||...||.:.:|.||.|||:|.
Human   638 AVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 702

  Fly   521 ------TMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDT 579
                  :.|:   ||:..:.:.|..:|:|...|....|..:...|:|:||.||.:.||:||.||.
Human   703 NLTSRLSDCV---ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDP 764

  Fly   580 RLNKWSVV 587
            :.|:|:.|
Human   765 QTNEWTQV 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	45/102 (44%)
		PHA03098	65..539	CDD:222983	207/482 (43%)
		BACK	174..276	CDD:285009	43/101 (43%)
		Kelch	324..369	CDD:128874	19/44 (43%)
		KELCH repeat	359..402	CDD:276965	21/42 (50%)
		Kelch	370..415	CDD:128874	23/44 (52%)
		KELCH repeat	406..450	CDD:276965	15/43 (35%)
		Kelch	417..463	CDD:128874	19/45 (42%)
		KELCH repeat	453..496	CDD:276965	15/42 (36%)
		Kelch	464..510	CDD:128874	17/45 (38%)
		Kelch_1	499..543	CDD:279660	16/52 (31%)
		KELCH repeat	500..545	CDD:276965	16/53 (30%)
		KELCH repeat	547..590	CDD:276965	17/41 (41%)
		Kelch	559..603	CDD:128874	15/29 (52%)
KLHL5	XP_011512001.1	BTB	244..347	CDD:279045	44/102 (43%)
		PHA03098	254..775	CDD:222983	224/525 (43%)
		BACK	356..455	CDD:285009	43/98 (44%)
		Kelch	503..548	CDD:128874	19/44 (43%)
		Kelch_1	537..582	CDD:279660	23/44 (52%)
		KELCH repeat	538..581	CDD:276965	21/42 (50%)
		KELCH repeat	585..629	CDD:276965	15/43 (35%)
		Kelch	598..642	CDD:128874	19/43 (44%)
		KELCH repeat	632..675	CDD:276965	15/42 (36%)
		Kelch	643..689	CDD:128874	17/45 (38%)
		Kelch_1	678..729	CDD:279660	16/53 (30%)
		KELCH repeat	679..729	CDD:276965	15/52 (29%)
		Kelch_1	732..772	CDD:279660	16/39 (41%)
		KELCH repeat	732..772	CDD:276965	16/39 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820