DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and Keap1

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001103775.1	Gene:	Keap1 / 50868	MGIID:	1858732	Length:	624	Species:	Mus musculus

Alignment Length:	612	Identity:	203/612 - (33%)
Similarity:	313/612 - (51%)	Gaps:	31/612 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLPVKSNHSGEASGNNEDVTTTSNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMR 66
            |||:.|. ..|.:|:     .....||:..::::|........   .:....|...:|..:|::|
Mouse    16 FLPLWSK-CPEGAGD-----AVMYASTECKAEVTPSQDGNRTF---SYTLEDHTKQAFGVMNELR 71

  Fly    67 NNAQLCDVRLEVGGDTI-----NAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQL 126
            .:.|||||.|:|..:.|     .||:|||||.||.|.|||.:.:.|:...:|.:..:....:.:|
Mouse    72 LSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERL 136

  Fly   127 IDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHT 191
            |::.||..|::.|:.|..::..:.:.|:.||..||..||::||.|||.:||.:||:...|.|||.
Mouse   137 IEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQ 201

  Fly   192 RSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAE 256
            |:.:|...:|.:|...|||..|...::..|||...||:..|..||.|.|:|||:|.|.||.::..
Mouse   202 RAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQA 266

  Fly   257 LMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMK 321
            |:..||...::..||.:.::...:::.|:.||:.|::..:...|.:.     :|....|.|: :.
Mouse   267 LLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKP-----TQAVPCRAPK-VG 325

  Fly   322 PYVFAVGG---GSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGY----DG 379
            ..::..||   .||    :..|.|||.:.||..:|.:...||......:...||.|||.    ||
Mouse   326 RLIYTAGGYFRQSL----SYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386

  Fly   380 VSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWS 444
            .:|.:..:.|||:||:||....|...|:.:|:...|..||..||..|....||:|||:|....|.
Mouse   387 NTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWH 451

  Fly   445 SCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTD 509
            ....|.|||....:|||...:|::||||.||..:|.|.:.|....|:.:..|:..||..||....
Mouse   452 LVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLH 516

  Fly   510 GHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSV 574
            ..:|..||.||...::|.||:.:...:|..:|.|...||...:...:|.::.|||.||.:.|:||
Mouse   517 NCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSV 581

  Fly   575 ERYDTRLNKWSVVNAMVARRSSVGAAV 601
            |.||...:.||.|..|.:.||.||.||
Mouse   582 ECYDPDSDTWSEVTRMTSGRSGVGVAV 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	38/107 (36%)
		PHA03098	65..539	CDD:222983	165/485 (34%)
		BACK	174..276	CDD:285009	38/101 (38%)
		Kelch	324..369	CDD:128874	13/47 (28%)
		KELCH repeat	359..402	CDD:276965	17/46 (37%)
		Kelch	370..415	CDD:128874	18/48 (38%)
		KELCH repeat	406..450	CDD:276965	15/43 (35%)
		Kelch	417..463	CDD:128874	19/45 (42%)
		KELCH repeat	453..496	CDD:276965	15/42 (36%)
		Kelch	464..510	CDD:128874	16/45 (36%)
		Kelch_1	499..543	CDD:279660	14/43 (33%)
		KELCH repeat	500..545	CDD:276965	15/44 (34%)
		KELCH repeat	547..590	CDD:276965	17/42 (40%)
		Kelch	559..603	CDD:128874	21/43 (49%)
Keap1	NP_001103775.1	BTB	67..176	CDD:279045	38/108 (35%)
		PHA03098	95..596	CDD:222983	175/510 (34%)
		BACK	184..286	CDD:285009	38/101 (38%)
		Kelch	327..372	CDD:128874	13/48 (27%)
		Kelch 1	327..372		13/48 (27%)
		KELCH repeat	362..409	CDD:276965	17/46 (37%)
		Kelch	373..423	CDD:128874	18/49 (37%)
		Kelch 2	373..423		18/49 (37%)
		KELCH repeat	413..456	CDD:276965	15/42 (36%)
		Kelch 3	424..470		19/45 (42%)
		Kelch	424..469	CDD:128874	18/44 (41%)
		KELCH repeat	460..503	CDD:276965	15/42 (36%)
		Kelch	471..517	CDD:128874	16/45 (36%)
		Kelch 4	471..517		16/45 (36%)
		KELCH repeat	507..551	CDD:276965	14/43 (33%)
		Kelch	518..564	CDD:128874	13/45 (29%)
		Kelch 5	519..564		13/44 (30%)
		KELCH repeat	554..597	CDD:276965	17/42 (40%)
		Kelch	565..611	CDD:128874	21/44 (48%)
		Kelch 6	565..611		21/44 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820