DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and KLHL17

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_006710663.1	Gene:	KLHL17 / 339451	HGNCID:	24023	Length:	665	Species:	Homo sapiens

Alignment Length:	663	Identity:	329/663 - (49%)
Similarity:	434/663 - (65%)	Gaps:	69/663 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TQTPS--------DLSPPGPNEEVLPQAHHQNP-------------------GHCIA-------- 57
            ||:|.        :..||.|.:...|:|....|                   ||.:|
Human    12 TQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAHNSKRHYH 76

  Fly    58 -SFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSS 121
             :|.|:::||....|||:.|.|....|.||:|||||.||||:|||.::|.|..|..|.|||:|..
Human    77 DAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141

  Fly   122 ALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSC 186
            ||.||:.:.||.||.:.|.|||.||||:.|||::.||||||||||.||.||||||||.|||||||
Human   142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSC 206

  Fly   187 KELHTRSHKYALQNFQQVVGTEEFLLLPFE-----------------------EVRELISNSQLN 228
            .:|...:|:|.||:|..|..||||:|||.:                       :|.||:|:..||
Human   207 SDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQASSGLPGSTGPSPDLRSEDPHSQVLELVSSDSLN 271

  Fly   229 ISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLE 293
            :.|||.|:.||::|||||:..||.|:..||..|||||:|||||:..|:.|:|:|...:||:||:|
Human   272 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 336

  Fly   294 AMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFAIHNECEVYNPRSNSWSPVAPMLWR 358
            |:|:|||||||.::|:.||:.||.||..|.:||||||||||||.:||.|:.|::.|..||.|..|
Human   337 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTR 401

  Fly   359 RSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGG 423
            |:|.||.::..:||.||||||.|||||.|||:|:||.|.....|||:|||||:.:...|:|..||
Human   402 RARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGG 466

  Fly   424 YDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVG 488
            |||||||:|.||||||||.|:|..||||||||.|:|.|:..:|::||:||:::.::||:::|:|.
Human   467 YDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVN 531

  Fly   489 RWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVV 553
            .|.||.||.:||||.|||..:|.||..||||||.|::|.||:|.:..:||.:|.|:.|||||::|
Human   532 VWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLV 596

  Fly   554 EVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVLECFHLERGLVQTTNLX 618
            .::|.|:|:|||||||||||:|:|:.|.|||...:.|..||||||.||||..          |.
Human   597 AMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELL----------NFP 651

  Fly   619 PLASITESFAAAA 631
            |.:|.|.|.::.:
Human   652 PPSSPTLSVSSTS 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	57/102 (56%)
		PHA03098	65..539	CDD:222983	270/496 (54%)
		BACK	174..276	CDD:285009	58/124 (47%)
		Kelch	324..369	CDD:128874	25/44 (57%)
		KELCH repeat	359..402	CDD:276965	24/42 (57%)
		Kelch	370..415	CDD:128874	28/44 (64%)
		KELCH repeat	406..450	CDD:276965	28/43 (65%)
		Kelch	417..463	CDD:128874	33/45 (73%)
		KELCH repeat	453..496	CDD:276965	18/42 (43%)
		Kelch	464..510	CDD:128874	21/45 (47%)
		Kelch_1	499..543	CDD:279660	24/43 (56%)
		KELCH repeat	500..545	CDD:276965	24/44 (55%)
		KELCH repeat	547..590	CDD:276965	25/42 (60%)
		Kelch	559..603	CDD:128874	28/43 (65%)
KLHL17	XP_006710663.1	BTB	82..186	CDD:279045	57/103 (55%)
		PHA03098	92..581	CDD:222983	266/488 (55%)
		BACK	194..318	CDD:285009	58/123 (47%)
		Kelch	366..412	CDD:128874	25/45 (56%)
		Kelch_1	401..446	CDD:279660	25/44 (57%)
		KELCH repeat	402..445	CDD:276965	24/42 (57%)
		KELCH repeat	449..492	CDD:276965	27/42 (64%)
		Kelch	460..506	CDD:128874	33/45 (73%)
		KELCH repeat	496..540	CDD:276965	19/43 (44%)
		Kelch	508..553	CDD:128874	21/44 (48%)
		KELCH repeat	543..587	CDD:276965	23/43 (53%)
		Kelch	555..600	CDD:128874	23/44 (52%)
		KELCH repeat	590..635	CDD:276965	26/44 (59%)
		Kelch	602..646	CDD:128874	28/43 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5378
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27075
Inparanoid	1	1.050	659	1.000	Inparanoid score	I773
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		oto91409
orthoMCL	1	0.900	-	-		OOG6_111129
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5119
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870