DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and Gan

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001100904.1	Gene:	Gan / 307893	RGDID:	1307766	Length:	603	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	160/618 - (25%)
Similarity:	275/618 - (44%)	Gaps:	88/618 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAM--------FNDDMLE 107
            :|.|......|::..|..|:.||..|.:.|:.|...:.:||:.||:|...        :|....:
  Rat     9 DPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPHFTFFPFLRTKLNYNPPKDD 73

  Fly   108 RTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPS 172
            .:...:.|..:..:.:|:::||.::|:|.:.|..:|.::.|:.||.:..::..||:||...:...
  Rat    74 GSTYKIELEGISVTIMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAE 138

  Fly   173 NCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFA 237
            ||:|||.||..:....:|..:.:|...:|:.|..|||||.|..::::|:||..:||:.:|..||.
  Rat   139 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFE 203

  Fly   238 AVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRD-DSECKELLLEAMKYHLLP 301
            |||.|:.||:..|::|:.::||.:.:..:...:|...:..|.|:|: ..||..:.|..      |
  Rat   204 AVIRWIAHDVEMRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQ------P 262

  Fly   302 EQRSIMGSQRTQERRPEGMKPYVFAVGGGS------LFAIHNECEVYNPRSNSWSPVAPMLWRRS 360
            :|    |.......:|.|....:..:||..      ..|:...|.:|:|....|..:||:...|.
  Rat   263 QQ----GEAMLASFKPRGYSECIVTIGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRI 323

  Fly   361 RSGVTSLHKQLYVVGGYD-GVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGY 424
            ..||.|....|:|:||.| ....|::.|.|:|..|.|:.:.||...|...||...|.::|:.||.
  Rat   324 NHGVLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGE 388

  Fly   425 DGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGR 489
            ||...|.|||.||..:..|:..|.::..|:....|.::..||::||........|||.:|||..:
  Rat   389 DGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQ 453

  Fly   490 WQPVPSMSARR---SSCGVASTDGHLYCIGG------------------------------NDGT 521
            |..:..:..||   .:||||.   .||..||                              ||..
  Rat   454 WTAICPLKERRFGAVACGVAM---ELYVFGGVRSREDIQGSEMVTCKSEFYHDEFKRWIYLNDQN 515

  Fly   522 MCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSV 586
            :|:.:...|                  .:..|.:..:::.:|..|..::.:.|..:......|..
  Rat   516 LCIPASSSF------------------VYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHH 562

  Fly   587 VNAMV---ARRSSVGA-AVLEC----FHLERGL 611
            ...::   .||:...| .:..|    ..|::||
  Rat   563 TKPLLPSDLRRTGCAALRIANCKLFRLQLQQGL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	27/110 (25%)
		PHA03098	65..539	CDD:222983	145/522 (28%)
		BACK	174..276	CDD:285009	35/101 (35%)
		Kelch	324..369	CDD:128874	13/50 (26%)
		KELCH repeat	359..402	CDD:276965	15/43 (35%)
		Kelch	370..415	CDD:128874	16/45 (36%)
		KELCH repeat	406..450	CDD:276965	17/43 (40%)
		Kelch	417..463	CDD:128874	15/45 (33%)
		KELCH repeat	453..496	CDD:276965	13/42 (31%)
		Kelch	464..510	CDD:128874	17/48 (35%)
		Kelch_1	499..543	CDD:279660	14/76 (18%)
		KELCH repeat	500..545	CDD:276965	13/77 (17%)
		KELCH repeat	547..590	CDD:276965	5/42 (12%)
		Kelch	559..603	CDD:128874	7/47 (15%)
Gan	NP_001100904.1	BTB	20..131	CDD:279045	26/110 (24%)
		PHA03098	28..508	CDD:222983	139/492 (28%)
		BACK	140..241	CDD:285009	35/100 (35%)
		Kelch	280..332	CDD:128874	13/51 (25%)
		KELCH repeat	322..366	CDD:276965	15/43 (35%)
		Kelch	334..380	CDD:128874	16/45 (36%)
		Kelch_1	369..414	CDD:279660	17/44 (39%)
		KELCH repeat	370..414	CDD:276965	17/43 (40%)
		KELCH repeat	417..462	CDD:276965	13/44 (30%)
		Kelch	428..470	CDD:128874	13/41 (32%)
		KELCH repeat	464..517	CDD:276965	11/55 (20%)
		KELCH repeat	520..567	CDD:276965	6/64 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810