DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and Klhl28

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001100205.1	Gene:	Klhl28 / 299103	RGDID:	1311326	Length:	571	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	213/572 - (37%)
Similarity:	326/572 - (56%)	Gaps:	21/572 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HQNPGHCIASFA---------AINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDD 104
            |..|.:.:|:..         .:|.:|.:.:|||:.|.||...|:||:|||||:||||.|||..:
  Rat     3 HTAPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASISPYFKAMFTGN 67

  Fly   105 MLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQL 169
            :.|:....|....:|.:||:.:::|.|||.:.|::..|:.||||:.|||:..|...||.||..||
  Rat    68 LSEKENSEVEFQCIDEAALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCTFLESQL 132

  Fly   170 HPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEER 234
            .|.||:||..||:.:.|.:|:..:.|:..|||:.|..||||..|...::.|::||..||:::||.
  Rat   133 DPGNCIGISRFAETYGCHDLYLAATKFICQNFESVCQTEEFFELTHGDLDEIVSNDCLNVATEET 197

  Fly   235 VFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHL 299
            ||.|:.:|:|:|:..|:.::|:|:::|||||:|..||....|...|:|||..||.||.||:|||.
  Rat   198 VFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHF 262

  Fly   300 LPEQRSIMGSQRTQERRPEGMKPYVFAVGGGS-LFAIHNECEVYNPRSNSWSPVAPMLWRRSRSG 363
            :||.|  :..|.....||......:.||||.| |||..:..|:|.|:::||..:||:...|...|
  Rat   263 MPEHR--LSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFG 325

  Fly   364 VTSLHKQLYVVGGYD-----GVS---DLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYV 420
            :..|.:::||:||.:     ||:   ...:.|.:||.||.|:::..|...||.||:......:|.
  Rat   326 ICVLDQKVYVIGGIETSVRPGVTVRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGEVYA 390

  Fly   421 CGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDP 485
            .|||||.|.|.|:|:|.|....|.....|:|.|.....|||:..||::||:... :.:||||:||
  Rat   391 LGGYDGQSYLQSVEKYIPKIRQWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPA-HMNSVERYDP 454

  Fly   486 RVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTH 550
            ....|:.|.||:.:|...||....|.::.:||::|...:||.||:...:|.|.....|...|:..
  Rat   455 SKDSWETVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGV 519

  Fly   551 EVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVL 602
            ....::..|:.:||:.|||.||:|::||...:.|.....|:..|.:.|...|
  Rat   520 GAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	45/102 (44%)
		PHA03098	65..539	CDD:222983	191/482 (40%)
		BACK	174..276	CDD:285009	41/101 (41%)
		Kelch	324..369	CDD:128874	18/45 (40%)
		KELCH repeat	359..402	CDD:276965	15/50 (30%)
		Kelch	370..415	CDD:128874	17/52 (33%)
		KELCH repeat	406..450	CDD:276965	17/43 (40%)
		Kelch	417..463	CDD:128874	19/45 (42%)
		KELCH repeat	453..496	CDD:276965	16/42 (38%)
		Kelch	464..510	CDD:128874	17/45 (38%)
		Kelch_1	499..543	CDD:279660	13/43 (30%)
		KELCH repeat	500..545	CDD:276965	14/44 (32%)
		KELCH repeat	547..590	CDD:276965	13/42 (31%)
		Kelch	559..603	CDD:128874	16/44 (36%)
Klhl28	NP_001100205.1	PHA03098	35..553	CDD:222983	202/520 (39%)
		KELCH repeat	321..372	CDD:276965	15/50 (30%)
		KELCH repeat	376..419	CDD:276965	17/42 (40%)
		KELCH repeat	423..465	CDD:276965	16/42 (38%)
		KELCH repeat	469..513	CDD:276965	13/43 (30%)
		KELCH repeat	516..559	CDD:276965	13/42 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830