DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and Klhl1

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001381602.1	Gene:	Klhl1 / 290426	RGDID:	1307452	Length:	750	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	228/599 - (38%)
Similarity:	344/599 - (57%)	Gaps:	20/599 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SGEASGNNEDVTTTSNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDV 74
            :||..|:.   .||:|:|....|||. ...:||.....||..     .||..:.......|||||
  Rat   161 TGEGCGHR---LTTTNHSLTPQSDLD-SSSSEEFYQAVHHAE-----QSFRKMENYLKQQQLCDV 216

  Fly    75 RLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITE 139
            .|.||...|.|||:||:|||.||.|||..|:.|..|..:::..:|.:||..|:.:.|||.:.:.|
  Rat   217 ILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKE 281

  Fly   140 QNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQV 204
            ..::.||.|:.|||:..|.:.||.||::.||||||||||:||||..|.||...:|.|.::|..:|
  Rat   282 DTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEV 346

  Fly   205 VGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRD 269
            :..:||||||.||:.:|:::..:|:..||.:|.|::.|||:|:..|...::.|::.:||||:...
  Rat   347 IRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCGDLSMLLAFIRLPLLPPQ 411

  Fly   270 FLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFA 334
            .|.. :|...|.::|.||::|:|||||||||||:|::|.|.||:.|:  .....::||||.....
  Rat   412 ILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRK--STVGTLYAVGGMDNNK 473

  Fly   335 IHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNI 399
            .....|.|:.|:|.|.....|..||.:.||..:..:|:|:||.||:..|.|.|.|||.|..|:.:
  Rat   474 GATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVL 538

  Fly   400 TPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENC 464
            .||.|.|..||:...:..||..||:||.|.|:::||:||.:..|:...:||..|....:|.|...
  Rat   539 PPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGK 603

  Fly   465 IYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDG------TMC 523
            :||:||.|.::..||:|.:||...:|.....|..||...|||:.||.||.:||:|.      :..
  Rat   604 LYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRL 668

  Fly   524 MSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVN 588
            :...||:..:.::|..:|.:...|....|..:...|:|:||.||.:.||::|.||.:.|:|:.:.
  Rat   669 LDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMA 733

  Fly   589 AMVARRSSVGAAVL 602
            ::...|:  ||.|:
  Rat   734 SLNIGRA--GACVV 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	43/102 (42%)
		PHA03098	65..539	CDD:222983	192/479 (40%)
		BACK	174..276	CDD:285009	41/101 (41%)
		Kelch	324..369	CDD:128874	14/44 (32%)
		KELCH repeat	359..402	CDD:276965	17/42 (40%)
		Kelch	370..415	CDD:128874	20/44 (45%)
		KELCH repeat	406..450	CDD:276965	16/43 (37%)
		Kelch	417..463	CDD:128874	18/45 (40%)
		KELCH repeat	453..496	CDD:276965	14/42 (33%)
		Kelch	464..510	CDD:128874	17/45 (38%)
		Kelch_1	499..543	CDD:279660	16/49 (33%)
		KELCH repeat	500..545	CDD:276965	15/50 (30%)
		KELCH repeat	547..590	CDD:276965	15/42 (36%)
		Kelch	559..603	CDD:128874	17/44 (39%)
Klhl1	NP_001381602.1	PHA03098	208..730	CDD:222983	207/524 (40%)
		KELCH repeat	498..541	CDD:276965	17/42 (40%)
		KELCH repeat	545..589	CDD:276965	16/43 (37%)
		KELCH repeat	592..635	CDD:276965	14/42 (33%)
		KELCH repeat	639..689	CDD:276965	15/49 (31%)
		KELCH repeat	692..736	CDD:276965	15/43 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920