DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15097 and Ivns1abp

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_006250050.1	Gene:	Ivns1abp / 289089	RGDID:	1306290	Length:	642	Species:	Rattus norvegicus

Alignment Length:	624	Identity:	174/624 - (27%)
Similarity:	284/624 - (45%)	Gaps:	101/624 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSS 121
            :|.|.:|.:|.:.|.|||||:|.|..:.|||.|||..|||.:.:||.|........|:|.|::..
  Rat    17 SSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGVSHVKLDDLNPE 81

  Fly   122 ALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSC 186
            |:..|::|.||.::...::.|:.:..|:..|:|..|:..|..:||.::..::|:..|:||.....
  Rat    82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGD 146

  Fly   187 KELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRR 251
            ..|..:...|..::..|:...||||.||..:: |::....:.:.|..:::..|||||:..:....
  Rat   147 SRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWENG 210

  Fly   252 LHIAELMSNVRLPLVSRDFLM-----SCVETETLMRDDSECK----------------------- 288
            ..:.|||..|:....|.|..:     ...:.|....||...:
  Rat   211 DSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISGSSTGCL 275

  Fly   289 ---ELLLEAMKYHLLPEQRSIMGSQRTQ------------------------------------- 313
               ...:::.|:     :..|:.|::|.
  Rat   276 SSPNASVQSPKH-----EWKIVASEKTSNNTYLCLAVLDGTFCVIFLHGRNSPQSSPTSTPKLSK 335

  Fly   314 ----ERRPE-----GMKPYVFAVGG-------GSLFAI----HNEC----EVYNPRSNSWSPVAP 354
                |.:|:     .|.|..:|..|       |.|.|.    ..||    |.|:|.::.||.:||
  Rat   336 SLSFEMQPDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTDHWSFLAP 400

  Fly   355 MLWRRSRSGVTSLHKQLYVVGGYDGVS-DLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALI 418
            |...|:|..:..|..|||||||.:|.| ||:..|.|:|..:.|:.:..:.|.|...|:|:.:..:
  Rat   401 MRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPSIDDWTPVPELRTNRCNAGVCALNGKL 465

  Fly   419 YVCGGYD--GASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVE 481
            |:.||.|  |...|.:.:.:||:|..|:||..::.||....:..|...:|.:||.:|.|..::||
  Rat   466 YIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVE 530

  Fly   482 RFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSR 546
            |::|....|..:..|:..|...|||..||.|:..||.||:..:|..|.:...||.|:.:..|.|.
  Rat   531 RYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYDPTRNEWKMMGNMTSP 595

  Fly   547 RSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWS 585
            ||...:..|...::|:||.||:..||:||.|:...|:||
  Rat   596 RSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	36/102 (35%)
		PHA03098	65..539	CDD:222983	153/568 (27%)
		BACK	174..276	CDD:285009	26/106 (25%)
		Kelch	324..369	CDD:128874	18/59 (31%)
		KELCH repeat	359..402	CDD:276965	18/43 (42%)
		Kelch	370..415	CDD:128874	19/45 (42%)
		KELCH repeat	406..450	CDD:276965	15/45 (33%)
		Kelch	417..463	CDD:128874	15/47 (32%)
		KELCH repeat	453..496	CDD:276965	12/42 (29%)
		Kelch	464..510	CDD:128874	15/45 (33%)
		Kelch_1	499..543	CDD:279660	16/43 (37%)
		KELCH repeat	500..545	CDD:276965	17/44 (39%)
		KELCH repeat	547..590	CDD:276965	16/39 (41%)
		Kelch	559..603	CDD:128874	13/27 (48%)
Ivns1abp	XP_006250050.1	BTB_POZ_NS1BP	14..137	CDD:349615	41/119 (34%)
		PHA03098	23..638	CDD:222983	172/618 (28%)
		BACK_NS1BP_IVNS1ABP	129..225	CDD:350577	24/96 (25%)
		KELCH repeat	358..401	CDD:276965	12/42 (29%)
		KELCH repeat	405..450	CDD:276965	18/44 (41%)
		KELCH repeat	453..498	CDD:276965	15/44 (34%)
		KELCH repeat	502..546	CDD:276965	12/43 (28%)
		KELCH repeat	549..592	CDD:276965	16/42 (38%)
		KELCH repeat	596..635	CDD:276965	16/39 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820