DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and Klhl20

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001034571.1	Gene:	Klhl20 / 226541	MGIID:	2444855	Length:	604	Species:	Mus musculus

Alignment Length:	587	Identity:	246/587 - (41%)
Similarity:	357/587 - (60%)	Gaps:	4/587 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TSNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHR 87
            ||..:...|:.|....|....:|....::|..   :...||.:|.:.:||||.|.||...|.|||
Mouse    17 TSRCTLGDPNKLPEGVPQPARMPYISDKHPRQ---TLEVINLLRKHRELCDVVLVVGAKKIYAHR 78

  Fly    88 VVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLL 152
            |:|::.||||.|||..::.|..|..|.:.|:|..|:..|||:.||.:||:.|.|||.||||:.||
Mouse    79 VILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 143

  Fly   153 QMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEE 217
            |:..:::|||:||.|||.||||||||:|||.|||:||...:.|:...|||:|:.:|||:|||..:
Mouse   144 QLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQ 208

  Fly   218 VRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMR 282
            :.::||:.:||:.|||:||.||:.|||:.:..||..:.:::.:|||||:|..||:..|.::.|::
Mouse   209 LIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIK 273

  Fly   283 DDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFAIHNECEVYNPRSN 347
            .|.||::|:.||..|.|||::|.:|...||:.|:|......:|||||.......:..|.|:|::|
Mouse   274 SDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTN 338

  Fly   348 SWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKW-SNITPMGTKRSCLGI 411
            .|..||.|..||...||:.|...||.|||:||.|.|.:.|.|:|.||:| |::.|..|.|:.:|:
Mouse   339 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGV 403

  Fly   412 CSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNY 476
            ......:|..||.||.|||:.:|||||....|:...:|||||....:|||...:|::||.|.|:.
Mouse   404 AVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP 468

  Fly   477 QSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIA 541
            .::|||::|:..||..:..|..||...|.|.....:|.:||.|.|..:||.||::.|.|.|.|:.
Mouse   469 LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVV 533

  Fly   542 AMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVLECFH 606
            ||.||||...:..|.|.|.|:||.||::.|.::|.:|...|.|.:...|..||...|..|::..|
Mouse   534 AMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTH 598

  Fly   607 LE 608
            .|
Mouse   599 CE 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	50/102 (49%)
		PHA03098	65..539	CDD:222983	210/474 (44%)
		BACK	174..276	CDD:285009	48/101 (48%)
		Kelch	324..369	CDD:128874	18/44 (41%)
		KELCH repeat	359..402	CDD:276965	20/43 (47%)
		Kelch	370..415	CDD:128874	20/45 (44%)
		KELCH repeat	406..450	CDD:276965	16/43 (37%)
		Kelch	417..463	CDD:128874	22/45 (49%)
		KELCH repeat	453..496	CDD:276965	15/42 (36%)
		Kelch	464..510	CDD:128874	16/45 (36%)
		Kelch_1	499..543	CDD:279660	17/43 (40%)
		KELCH repeat	500..545	CDD:276965	18/44 (41%)
		KELCH repeat	547..590	CDD:276965	15/42 (36%)
		Kelch	559..603	CDD:128874	16/43 (37%)
Klhl20	NP_001034571.1	BTB_POZ_KLHL20_KLEIP	40..167	CDD:349558	60/129 (47%)
		PHA03098	58..581	CDD:222983	229/522 (44%)
		Kelch 1	314..360		18/45 (40%)
		KELCH repeat	350..394	CDD:276965	20/43 (47%)
		Kelch 2	362..408		20/45 (44%)
		KELCH repeat	398..442	CDD:276965	16/43 (37%)
		Kelch 3	409..455		22/45 (49%)
		KELCH repeat	445..490	CDD:276965	16/44 (36%)
		Kelch 4	457..502		16/44 (36%)
		KELCH repeat	492..535	CDD:276965	16/42 (38%)
		Kelch 5	504..549		20/44 (45%)
		KELCH repeat	539..584	CDD:276965	16/44 (36%)
		Kelch 6	551..596		16/44 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820