DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15097 and kel-1

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001254310.1	Gene:	kel-1 / 174791	WormBaseID:	WBGene00002184	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	590	Identity:	213/590 - (36%)
Similarity:	323/590 - (54%)	Gaps:	44/590 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HQNPGHCIASFAAINQMRNNAQLCDVRLE---VGGDT------------INAHRVVLASVSPYFY 98
            :.||......:..:|.||...:||||.||   :.|.:            |:||||:|::.|.||.
Worm    33 YSNPTMLGEFYQNLNLMRCQQELCDVVLEAYPIQGTSSEDGMSDDVHQHIHAHRVILSASSSYFR 97

  Fly    99 AMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCK 163
            |||...:.|.||.::.:.:||...|.|||||.|||.:.|.|||||.:|..:.|||:..|||||.:
Worm    98 AMFTGGLRESTQRIIPIKEVDVEVLSQLIDYMYTGRMRIDEQNVQTILATASLLQLTCVRDACAR 162

  Fly   164 FLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLN 228
            |:|..|..:||:|:..||.||:|.:|...:..|..|:|.:::..||.|.|..:...|||.:.::.
Worm   163 FMLELLDMTNCVGMAEFARAHACHQLAHAAQLYTRQHFVEIIDNEELLSLDKDAFCELIQDDRIT 227

  Fly   229 ISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLE 293
            :.||:.|..||:|||.|:.|:||..:|||||||||||:..|:|......:.:::.|:.|..:::|
Worm   228 VPSEKPVMQAVLNWVAHEEPSRRPFLAELMSNVRLPLLGDDYLFEKWRNDEMIKSDAACLNVIIE 292

  Fly   294 AMKYHLLPEQRSIMGSQR----TQE--------RRPEGMKPYVFAVGGGSLFAIHNECEVYNPRS 346
            .|  |.|...:..:.|..    .||        |.|.....::..|||.:..||.| .::::|.|
Worm   293 GM--HQLKITKQDISSTEPHYPIQELNRKWFVAREPMPESQHIMIVGGQAPKAITN-VDLFDPDS 354

  Fly   347 NSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNITPMGTKRSCLGI 411
            ..||..|.:..||.||||:..:..:|..||::|...:.:.:.|:|.|:.|.:...|..:||..||
Worm   355 QLWSSCASLPQRRCRSGVSMCNGYVYTTGGFNGAQRVRSVDFYDPRTDTWRSANQMSARRSTHGI 419

  Fly   412 CSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNY 476
            .:...::|..||:||.:.|:|.|.:||.||.|...|:|||||....:|..|..||::||||..:.
Worm   420 TTCQQVLYAVGGFDGTTGLASAEYFDPHTGNWFPLPSMSTRRSSVGVAAFEEDIYAIGGFDGVSK 484

  Fly   477 Q--SSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEP 539
            |  ::||.||.|..:|:|.|:|...||..||...|..:..:||:.|.....|.|  .|....|..
Worm   485 QCLNTVEIFDRRAHKWRPGPAMLNVRSGAGVTVYDKKIIAVGGHKGAEIHRSAE--ILIGEEWIE 547

  Fly   540 IAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVE------RYDTRLNKWSVVNAMVAR-RSSV 597
            :|.|...|.......:.|.|:|:||:||||:|:::|      |.|.   :|.:|:|.::: ||..
Worm   548 LANMAIPRRNTAATALNGLLYAVGGDDGSSNLSTIECIQLSDRSDA---QWKIVDAPMSQGRSYA 609

  Fly   598 GAAVL 602
            |.|::
Worm   610 GIALI 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	52/117 (44%)
		PHA03098	65..539	CDD:222983	187/502 (37%)
		BACK	174..276	CDD:285009	43/101 (43%)
		Kelch	324..369	CDD:128874	17/44 (39%)
		KELCH repeat	359..402	CDD:276965	13/42 (31%)
		Kelch	370..415	CDD:128874	13/44 (30%)
		KELCH repeat	406..450	CDD:276965	18/43 (42%)
		Kelch	417..463	CDD:128874	20/45 (44%)
		KELCH repeat	453..496	CDD:276965	18/44 (41%)
		Kelch	464..510	CDD:128874	20/47 (43%)
		Kelch_1	499..543	CDD:279660	13/43 (30%)
		KELCH repeat	500..545	CDD:276965	14/44 (32%)
		KELCH repeat	547..590	CDD:276965	16/48 (33%)
		Kelch	559..603	CDD:128874	19/51 (37%)
kel-1	NP_001254310.1	PHA03098	82..603	CDD:222983	197/528 (37%)
		KELCH repeat	367..410	CDD:276965	13/42 (31%)
		KELCH repeat	414..458	CDD:276965	18/43 (42%)
		KELCH repeat	461..507	CDD:276965	18/45 (40%)
		KELCH repeat	510..552	CDD:276965	13/43 (30%)
		KELCH repeat	555..604	CDD:276965	17/51 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I4542
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920