DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and Ipp

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_032415.2	Gene:	Ipp / 16351	MGIID:	96581	Length:	584	Species:	Mus musculus

Alignment Length:	594	Identity:	181/594 - (30%)
Similarity:	301/594 - (50%)	Gaps:	42/594 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NEEVLPQA---HHQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMF 101
            ::|..|:|   ...:..|.....|.:|:||:....|||:|:||.:|...||:|||:.||||.|:|
Mouse     2 SKEECPKAADNSFSSDKHAQLILAQMNKMRSGQHFCDVQLQVGKETFQVHRLVLAASSPYFAALF 66

  Fly   102 NDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLL 166
            ...|.|.::.:|::..|::...:.|:|:.|||.:.|...|||.|:.|:.:||:..|.:.||.||.
Mouse    67 TGGMKESSKDVVQILGVEAGIFQLLLDFIYTGVVNIAVTNVQELIVAADMLQLTEVVNLCCDFLK 131

  Fly   167 RQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISS 231
            .|:.|.||:|:..|::..:|.:|...:..|...:|.:|...||||.|..:::.:::.:.:|:|..
Mouse   132 GQIDPQNCIGLFQFSEQIACHDLLEFTENYIHVHFLEVHTGEEFLGLTKDQLIKILRSEELSIED 196

  Fly   232 EERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVE----------TETLMRDDSE 286
            |.:||.|.:.|:..||..||.|:.|::..||.||:....|:..:|          .:||:::..|
Mouse   197 EYQVFLAAMQWILKDLGKRRKHVVEVLDPVRFPLLPSQRLLKYIEGVSDFNLRVALQTLLKEYCE 261

  Fly   287 -CKELLLEAMKYHLLPEQRSIMGSQRTQERRP-EGMKPYVFAVGG-----GSLFAIHN--EC-EV 341
             ||.           |::.......:|.:.|| :..:.|::||||     |..::...  .| |.
Mouse   262 VCKS-----------PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVER 315

  Fly   342 YNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNITPMGTKR 406
            ::..|..|:.|:.:...|...||..:...:|.:||..........|.|:|:|.:|:.:..|...|
Mouse   316 FDTFSQYWTTVSSLHQARCGLGVAVVGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPR 380

  Fly   407 SCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGF 471
            ..||:|.....||..||:.||...:::||:||....|....:|:..|.|.....::..||::||.
Mouse   381 CGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGSMAVSRYYFGCCEMQGLIYAVGGI 445

  Fly   472 DSTNYQ-SSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGG-NDGTMCMSSGERFSLRR 534
            .:...: .|.|.:||...||.|:|.|..||:..|||:.:..:|.||| |:....:.:.|::|...
Mouse   446 SNEGLELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEE 510

  Fly   535 NSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGS------SSLNSVERYDTRLNKWSVVNAMVAR 593
            ..|..:|:|...|:....|.|.|.|:..||...|      .:|:|||.|:...:.|:.:..|:..
Mouse   511 EKWVEVASMKVPRAGMCAVTVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITS 575

  Fly   594 RSSVGAAVL 602
            |...|.|||
Mouse   576 RCEGGVAVL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	42/102 (41%)
		PHA03098	65..539	CDD:222983	153/495 (31%)
		BACK	174..276	CDD:285009	31/101 (31%)
		Kelch	324..369	CDD:128874	13/52 (25%)
		KELCH repeat	359..402	CDD:276965	11/42 (26%)
		Kelch	370..415	CDD:128874	13/44 (30%)
		KELCH repeat	406..450	CDD:276965	15/43 (35%)
		Kelch	417..463	CDD:128874	14/45 (31%)
		KELCH repeat	453..496	CDD:276965	14/43 (33%)
		Kelch	464..510	CDD:128874	18/46 (39%)
		Kelch_1	499..543	CDD:279660	14/44 (32%)
		KELCH repeat	500..545	CDD:276965	14/45 (31%)
		KELCH repeat	547..590	CDD:276965	14/48 (29%)
		Kelch	559..603	CDD:128874	16/50 (32%)
Ipp	NP_032415.2	BTB	27..131	CDD:279045	42/103 (41%)
		PHA03098	34..575	CDD:222983	168/551 (30%)
		BACK	139..241	CDD:285009	31/101 (31%)
		Kelch	290..343	CDD:128874	13/52 (25%)
		Kelch 1	296..343		9/46 (20%)
		KELCH repeat	333..376	CDD:276965	11/42 (26%)
		Kelch 2	344..390		13/45 (29%)
		Kelch	345..390	CDD:128874	13/44 (30%)
		KELCH repeat	380..424	CDD:276965	15/43 (35%)
		Kelch 3	391..437		14/45 (31%)
		Kelch	392..437	CDD:128874	14/44 (32%)
		KELCH repeat	427..473	CDD:276965	15/45 (33%)
		Kelch	438..485	CDD:128874	18/46 (39%)
		Kelch 4	439..485		18/45 (40%)
		KELCH repeat	475..520	CDD:276965	13/44 (30%)
		Kelch	486..533	CDD:128874	13/46 (28%)
		Kelch 5	487..533		13/45 (29%)
		KELCH repeat	523..574	CDD:276965	15/50 (30%)
		Kelch	534..584	CDD:128874	14/49 (29%)
		Kelch 6	535..583		13/47 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820