Protein Alignment CG15097 and KLHL41

DIOPT Version :10

• Sequence 1: NP_001261079.1
• Gene: CG15097 / 37172
• FlyBaseID: FBgn0034396
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_006054.2
• Gene: KLHL41 / 10324
• HGNCID: 16905
• Length: 606
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 152/593 - (25%)
• Similarity: 261/593 - (44%)
• Gaps: 55/593 - (9%)

  Fly    62 INQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQL 126
            :..:.:..:..|..|:.|..::..||::|::.||||...|..::.|..:..|.|.:||.:.|..:
Human    23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLI 87

  Fly   127 IDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHT 191
            |.|.|:..|.:.:.|||.:...:...|:.||...|..:|.::|.|.|||.|........|..|..
Human    88 IKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAI 152

  Fly   192 RSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAE 256
            .:.::....|.|:...|:|:.|..:|:..:|||..||:..||.||.||:.||:.|...|..:::|
Human   153 SAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSE 217

  Fly   257 LMSNVRLPLVSRDFLMSCVETETLMRD--DSECKELLLEAMKYHLLPEQR---------SIMGSQ 310
            :...:|..|::..:....||.:.:::.  |.:.|..:|:......|||..         .:.|..
Human   218 VFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDV 282

  Fly   311 RTQERRP--------EGM--KPYVFAVGGGSLFAIHNECEVYNPRSNS--WSPVAPMLWRRSRSG 363
            ..::..|        .||  |..:..|...:..|       |:|..|.  .:.:|..: .|:.|.
Human   283 GDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVA-------YDPTENECYLTALAEQI-PRNHSS 339

  Fly   364 VTSLHKQLYVVGG--YDGVSDLATAESY----NPLTNKWSNITPMGTKRSCLGICSYDALIYVCG 422
            :.:...|:|||||  .|..:.....:||    :.:.::|..:.|:.:.|...|:...|..|||..
Human   340 IVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVA 404

  Fly   423 GYD--GASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGG-FDSTNYQSSVERFD 484
            |.|  ..:.|.|:..|||:...|:....:..:.....:...:..||.||| .|.....:.|..|:
Human   405 GKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFN 469

  Fly   485 PRVGRWQPVPSMSARRSSCGVASTDGHLYCIGG--NDGTMCMSSGERFSLRRNSWEPIAAMHSRR 547
            |:.|.|:.:..|...||..|||...|.:...||  .||  ..:|.|.|.|..|.|:.:......|
Human   470 PKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDG--LSASVEAFDLTTNKWDVMTEFPQER 532

  Fly   548 STHEVVEVEGALFALGG---------NDGSSSLNSVERYDTRLNKWS--VVNAMVARRSSVGAAV 601
            |:..:|.:.|:|:|:||         ....:.:|.:.:|:....:|:  :.....|..:|..|..
Human   533 SSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATR 597

  Fly   602 LECFHLER 609
            |..|.|.:
Human   598 LNLFKLSK 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB_POZ	51..171	CDD:453885	30/108 (28%)
		PHA03098	65..539	CDD:222983	135/507 (27%)
		BACK	169..282	CDD:475122	34/112 (30%)
		KELCH repeat	359..402	CDD:276965	12/48 (25%)
		KELCH repeat	406..450	CDD:276965	14/45 (31%)
		KELCH repeat	453..496	CDD:276965	11/43 (26%)
		KELCH repeat	500..545	CDD:276965	16/46 (35%)
		KELCH repeat	547..590	CDD:276965	11/53 (21%)
		Kelch	559..603	CDD:128874	10/54 (19%)
KLHL41	NP_006054.2	BTB_POZ_KLHL41_KBTBD10	6..135	CDD:349650	31/111 (28%)
		PHA03098	39..578	CDD:222983	143/548 (26%)
		KELCH repeat	335..384	CDD:276965	12/48 (25%)
		Kelch 1	346..398		13/51 (25%)
		KELCH repeat	388..433	CDD:276965	14/44 (32%)
		Kelch 2	399..447		11/47 (23%)
		KELCH repeat	437..482	CDD:276965	11/44 (25%)
		Kelch 3	448..495		17/46 (37%)
		KELCH repeat	485..530	CDD:276965	16/46 (35%)
		Kelch 4	497..542		13/46 (28%)
		Kelch 5	544..599		10/54 (19%)