DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and gan

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_003200482.3	Gene:	gan / 100537435	ZFINID:	ZDB-GENE-121221-1	Length:	609	Species:	Danio rerio

Alignment Length:	602	Identity:	159/602 - (26%)
Similarity:	272/602 - (45%)	Gaps:	66/602 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAM--FNDDMLERTQGLV 113
            :|.|.......:...|.:....|..|.:.|:.|...:.:||:.|||....  :|....:.:...:
Zfish    17 DPQHSQKLLRVLQSFRQDDCFQDAVLVLEGEQIPVQKNILAAASPYIRTKLNYNPPKEDGSVYTI 81

  Fly   114 RLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIR 178
            .|..:..:.:||::||.::||||::|..:|.::.|:.||.:..::..||:||...:...||:|||
Zfish    82 ELQGIAVTTMRQILDYIFSGEITLSEDTIQDVVQAADLLLLTDLKSLCCQFLESCITAENCIGIR 146

  Fly   179 SFADAHSCKELHTRSH---KYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVI 240
            .|: .|.|  ||...|   ::...:|:.|..|||||..|.:.:.||:|..:||:.:|..|..||:
Zfish   147 VFS-LHYC--LHHVYHVATEFLQTHFRDVANTEEFLEQPPDRLCELLSMEKLNVGNERHVLEAVV 208

  Fly   241 NWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRD------------DSECKELLLE 293
            .|:.||...||:|:.|:||.|.:..:.:.:|...:..::|||:            .::..|.||.
Zfish   209 RWIGHDTEARRVHMKEVMSAVWVQGLDQSYLQEQMLGDSLMREVIGNCCMESLGGAAQQGEALLA 273

  Fly   294 AMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFAIHNECEVYNPRSNSWSPVAPMLWR 358
            |.|.....|....:|.:....|:|..:...:              |.:|:.....|..:.||..|
Zfish   274 AFKPRGYSECIVTVGGEERTSRKPTAVARCM--------------CPLYDRNRQLWIDLMPMKER 324

  Fly   359 RSRSGVTSLHKQLYVVGGYD-GVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCG 422
            |...||.|....::.:||.| ..:.|::.|.::|.||.|:.|..|...|...||...|.:|||.|
Zfish   325 RVGHGVVSAEGYVFAIGGMDENKTVLSSGEKFDPETNTWTQIPSMMQARQHFGIAELDGMIYVLG 389

  Fly   423 G-YDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPR 486
            | .:....|.:||.:||...:|...|.|:|.|::...|.::..:|.:||........|||.:||:
Zfish   390 GENEDTEVLLTMEVFDPHCNVWRMLPKMTTVRKFGSCATMKKRLYVMGGGSYGKIYDSVECYDPK 454

  Fly   487 VGRWQPVPSMSARR---SSCGVASTDGHLYCIGG-----------NDGTMCMSSGERFSLRRNSW 537
            ..:|..|..:..||   .:||:..   .||..||           :..|:|.|......|:|  |
Zfish   455 TQQWTTVCPLKERRFGAVACGIGQ---ELYVFGGVRNRDADNPESSQMTICKSEFFHDELKR--W 514

  Fly   538 ----EPIAAMHSRRS-THEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNAM----VAR 593
                :....:|:..| .:..|.:..:::.:|..|..:|.:.|..:......|.....:    :::
Zfish   515 VLLDDQNLCIHTTSSFVYGAVPIGASIYVVGELDTGTSFDYVREFRRSTGTWHPTRPLMPSDLSK 579

  Fly   594 RSSVGAAVLEC--FHLE 608
            .|.....:..|  |.|:
Zfish   580 TSCAALRIANCKLFRLQ 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	28/104 (27%)
		PHA03098	65..539	CDD:222983	145/510 (28%)
		BACK	174..276	CDD:285009	38/104 (37%)
		Kelch	324..369	CDD:128874	10/44 (23%)
		KELCH repeat	359..402	CDD:276965	14/43 (33%)
		Kelch	370..415	CDD:128874	14/45 (31%)
		KELCH repeat	406..450	CDD:276965	16/44 (36%)
		Kelch	417..463	CDD:128874	16/46 (35%)
		KELCH repeat	453..496	CDD:276965	12/42 (29%)
		Kelch	464..510	CDD:128874	14/48 (29%)
		Kelch_1	499..543	CDD:279660	14/61 (23%)
		KELCH repeat	500..545	CDD:276965	13/62 (21%)
		KELCH repeat	547..590	CDD:276965	7/43 (16%)
		Kelch	559..603	CDD:128874	6/47 (13%)
gan	XP_003200482.3	BTB	46..516	CDD:333434	142/491 (29%)
		KELCH repeat	325..369	CDD:276965	14/43 (33%)
		KELCH repeat	373..418	CDD:276965	16/44 (36%)
		KELCH repeat	421..466	CDD:276965	12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910