DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15097 and klhl17

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_004916201.1	Gene:	klhl17 / 100491332	XenbaseID:	XB-GENE-977875	Length:	627	Species:	Xenopus tropicalis

Alignment Length:	583	Identity:	320/583 - (54%)
Similarity:	418/583 - (71%)	Gaps:	10/583 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLV 113
            |.:..|...:|..:|:||....|||:.|.||...|..|:|||||.||||:|||.::|.|..|..|
Frog    54 HNSKRHYHDAFVCMNRMRQRGLLCDIVLHVGTKEIKGHKVVLASCSPYFHAMFTNEMSESRQTHV 118

  Fly   114 RLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIR 178
            .|||:|..||.||:.|.||.||.:.|.|||.||||:.|||::.||||||||||.||.||||||||
Frog   119 TLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIR 183

  Fly   179 SFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWV 243
            .|||.|||.:|...:|||.||:|.:|..||||:|||.::|.:|||:..||:.|||.|:.||:|||
Frog   184 GFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLNWV 248

  Fly   244 KHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMG 308
            |||:..||.|:..||..|||||:|||||||.|:||.|:|..||||:||:||:||||:||||.::.
Frog   249 KHDVDGRRQHVPRLMKCVRLPLLSRDFLMSSVDTELLVRHHSECKDLLIEALKYHLMPEQRGVLS 313

  Fly   309 SQRTQERRPEGMKPYVFAVGGGSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYV 373
            :.||:.||.||....:||||||||||||.:||.|:.|::.|..|..|..||:|.||.::..:||.
Frog   314 NSRTRPRRCEGASTVLFAVGGGSLFAIHGDCEAYDTRTDRWHMVTSMSTRRARVGVAAIGNKLYA 378

  Fly   374 VGGYDGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDP 438
            ||||||.|||||.|||:|:||.|.....|||:|||||:.....|:|..|||||||||:|.|||||
Frog   379 VGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAVLHGLLYAAGGYDGASCLNSAERYDP 443

  Fly   439 LTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSC 503
            |||.|:|..||||||||.|:|.|:..:|::||:||:::.::||:::|::..|.|:.:|.:||||.
Frog   444 LTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQINTWTPIANMLSRRSSA 508

  Fly   504 GVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGS 568
            |||..:|.||..||||||.|::|.||::.:.|:||.:|.|:.|||||::|.::|.|:|:||||||
Frog   509 GVAVLEGMLYVAGGNDGTSCLNSVERYNPKANTWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGS 573

  Fly   569 SSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVLECFHLERGLVQTTNLXPLASITESFAAAA 631
            |||||:|:|:.|.|||...:.|..||||||.||||..          |..|.:|.|.|.::.:
Frog   574 SSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELL----------NFPPPSSPTLSVSSTS 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	59/102 (58%)
		PHA03098	65..539	CDD:222983	271/473 (57%)
		BACK	174..276	CDD:285009	61/101 (60%)
		Kelch	324..369	CDD:128874	24/44 (55%)
		KELCH repeat	359..402	CDD:276965	24/42 (57%)
		Kelch	370..415	CDD:128874	28/44 (64%)
		KELCH repeat	406..450	CDD:276965	28/43 (65%)
		Kelch	417..463	CDD:128874	33/45 (73%)
		KELCH repeat	453..496	CDD:276965	16/42 (38%)
		Kelch	464..510	CDD:128874	18/45 (40%)
		Kelch_1	499..543	CDD:279660	24/43 (56%)
		KELCH repeat	500..545	CDD:276965	24/44 (55%)
		KELCH repeat	547..590	CDD:276965	25/42 (60%)
		Kelch	559..603	CDD:128874	28/43 (65%)
klhl17	XP_004916201.1	BTB_POZ_KLHL17_actinfilin	38..176	CDD:349555	66/121 (55%)
		PHA03098	77..543	CDD:222983	267/465 (57%)
		KELCH repeat	321..360	CDD:276965	21/38 (55%)
		KELCH repeat	364..407	CDD:276965	24/42 (57%)
		KELCH repeat	411..454	CDD:276965	27/42 (64%)
		KELCH repeat	458..502	CDD:276965	16/43 (37%)
		KELCH repeat	505..549	CDD:276965	23/43 (53%)
		KELCH repeat	552..597	CDD:276965	26/44 (59%)
		Kelch	564..608	CDD:128874	28/43 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5131
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H27075
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		oto105176
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5119
SonicParanoid	1	1.000	-	-		X131
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.040