DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15097 and klhl28

DIOPT Version :9

Sequence 1:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_017207216.1	Gene:	klhl28 / 100333404	-ID:	-	Length:	571	Species:	Danio rerio

Alignment Length:	573	Identity:	212/573 - (36%)
Similarity:	317/573 - (55%)	Gaps:	26/573 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFND 103
            |:.|.|.|              .:..:|.:.:|||:.|.||...|:||:|||||:||||.|||..
Zfish    16 PHSEQLLQ--------------GLQLLRQDHELCDIVLRVGDAKIHAHKVVLASISPYFKAMFTG 66

  Fly   104 DMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQ 168
            ::.|:....|....:|.:||:.:::|.|||.:.|:::.|:.||||:.|||:..|...||.||..|
Zfish    67 NLSEKETSEVEFQCIDEAALKAIVEYAYTGTVFISQETVESLLPAANLLQVKLVLKECCSFLESQ 131

  Fly   169 LHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEE 233
            |...||:||..||:.:.|.:|...:.|:..|:|::|..||||..|...|:.:::||..||:.:||
Zfish   132 LDAGNCIGISRFAETYGCHDLCLAASKFICQHFEEVCQTEEFFELTRAELDDIVSNDCLNVLTEE 196

  Fly   234 RVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYH 298
            .||.|:.:|:|:|:..|:.|:|:|:..|||||:|..||....|...|:|||..||.||.||:|||
Zfish   197 SVFYALESWIKYDVSERQQHLAQLLHCVRLPLLSVKFLTRLYEANHLIRDDHACKHLLNEALKYH 261

  Fly   299 LLPEQRSIMGSQRTQERRPEGMKPYVFAVGG-GSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRS 362
            .:||.|  :..|.....||......:.|||| ..|||.....|:|.|:::||..:||:...|...
Zfish   262 FMPEHR--LSYQTVLSTRPRCAPKVLLAVGGKAGLFATLESMEMYFPQTDSWLGLAPLPVPRYEF 324

  Fly   363 GVTSLHKQLYVVGGY-----DGVS---DLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIY 419
            ||..|.:|:||:||.     .|:|   ..::.|.::|.||.||:...|...||.||:......:|
Zfish   325 GVAVLEQQVYVLGGIATHMRQGISYRRHESSVERWHPDTNTWSSERRMAESRSTLGVVVLAGELY 389

  Fly   420 VCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFD 484
            ..|||||...|.|:|:|.|....|.....|:..|.....|||:..||::||:... :.:||||:|
Zfish   390 ALGGYDGQYYLQSVEKYLPKLKEWQPVAPMTKSRSCFATAVLDGMIYAIGGYGPA-HMNSVERYD 453

  Fly   485 PRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRST 549
            |....|..|..|:.:|.:.||....|.::.:||::|...:||.||:...:|.|.....|:..|:.
Zfish   454 PSKDSWDMVAPMADKRINFGVGVMLGFIFVVGGHNGVSHLSSIERYDPYQNQWTACRPMNEPRTG 518

  Fly   550 HEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVL 602
            .....|:..|:.:||:.|||.||:|:|||...:.|...:.|:..|.:.|...|
Zfish   519 VGSAVVDNLLYVVGGHSGSSYLNAVQRYDPLTDGWIDASGMMYCRCNFGLTAL 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	44/102 (43%)
		PHA03098	65..539	CDD:222983	188/482 (39%)
		BACK	174..276	CDD:285009	41/101 (41%)
		Kelch	324..369	CDD:128874	18/45 (40%)
		KELCH repeat	359..402	CDD:276965	17/50 (34%)
		Kelch	370..415	CDD:128874	18/52 (35%)
		KELCH repeat	406..450	CDD:276965	16/43 (37%)
		Kelch	417..463	CDD:128874	17/45 (38%)
		KELCH repeat	453..496	CDD:276965	16/42 (38%)
		Kelch	464..510	CDD:128874	16/45 (36%)
		Kelch_1	499..543	CDD:279660	13/43 (30%)
		KELCH repeat	500..545	CDD:276965	14/44 (32%)
		KELCH repeat	547..590	CDD:276965	15/42 (36%)
		Kelch	559..603	CDD:128874	17/44 (39%)
klhl28	XP_017207216.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930