DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15096 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_611376.1	Gene:	CG15096 / 37170	FlyBaseID:	FBgn0034394	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	438	Identity:	159/438 - (36%)
Similarity:	241/438 - (55%)	Gaps:	49/438 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RHFQVLLLFFALTVAYGCRVNLSVAVVAMTDAASVNPD------FPE---------------YNW 79
            |:...:|.||...:.|..|||||||:|.|.|:.:...|      .||               |.|
Human    39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQW 103

  Fly    80 SEKTKSLLLSSFFWGYVITQVPAGQLARKYGGKVMILSGLAICSILNILTPICAKIGGWQLVCAL 144
            ..:|:..:|.|||:||:|||:|.|.:|.|.|||:::..|:...::|.:.|||.|.:|...|: .|
Human   104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLI-VL 167

  Fly   145 RVVEGLCQGVVFPSTHTILSQWAPPKERATLGTCAYSGNQFGTILMLATSGVIAASPIGWPSIFY 209
            |.:|||.:||.||:.|.:.|.||||.||:.|.:.:|:|.|.||::.|..||:|... :.|..:||
Human   168 RALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYY-MNWTYVFY 231

  Fly   210 ISGGIGCVWSVVYFFFGAGSPQECKSISAEEKKLIEMSQADEVSGGQEQPKEQLPTPWLSFFTSP 274
            ..|.||..|.:::.:..:.:||:.|.||..||:.|..|..:::|       .|...||:....|.
Human   232 FFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLS-------SQKSVPWVPILKSL 289

  Fly   275 AFLVLIVSHSVHNWGFWTLLTEIPSYMKNILGKDIKSNALLSSLPY----VCMFAMSFVFSSISA 335
            ....::|:|..:||.|:||||.:|:|||.||..:::.|..||||||    :||........::.|
Human   290 PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRA 354

  Fly   336 QLN-NRNCISRSTSRKLFNSIGLWIPMVTLVGLGYVNPDQSELAVVLLCFTVGMNGATYLGFNTN 399
            :.| :..|:     |::|:.||:..|.|.||..|::..|.| |||..|..:..:.|....||:.|
Human   355 KWNFSTLCV-----RRIFSLIGMIGPAVFLVAAGFIGCDYS-LAVAFLTISTTLGGFCSSGFSIN 413

  Fly   400 HIDLSPNFAGILMGITNGVANIMSIIAPLIVGFIVTNEHDPE---QWR 444
            |:|::|::||||:||||..|.|     |.:||.::.....|:   |||
Human   414 HLDIAPSYAGILLGITNTFATI-----PGMVGPVIAKSLTPDAGVQWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15096	NP_611376.1	2A0114euk	36..480	CDD:129972	159/438 (36%)
CG15096	NP_611376.1	MFS	40..464	CDD:119392	158/434 (36%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	158/435 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850