DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15096 and SLC17A3

DIOPT Version :9

Sequence 1:	NP_611376.1	Gene:	CG15096 / 37170	FlyBaseID:	FBgn0034394	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001091956.1	Gene:	SLC17A3 / 10786	HGNCID:	10931	Length:	498	Species:	Homo sapiens

Alignment Length:	499	Identity:	139/499 - (27%)
Similarity:	233/499 - (46%)	Gaps:	50/499 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EAKNSN--KEDEAVGKH---SGLGVRHFQVLLLFFALTVAYGCRVNLSVAVVAM----------T 65
            |:||:.  :.||.:...   |....|:...|:|.|.........|.:::.:|||          .
Human    13 ESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLN 77

  Fly    66 DAASVNP----------------DFPEYNWSEKTKSLLLSSFFWGYVITQVPAGQLARKYGGKVM 114
            |::.|.|                ..|.|:||.:.:.::..:..:|.::|..|:|.||.:.|.|.:
Human    78 DSSEVLPVDSFGGLSKAPKSLPAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRV 142

  Fly   115 ILSGLAICSILNILTPICAKIGGWQLVCALRVVEGLCQGVVFPSTHTILSQWAPPKERATLGTCA 179
            :...|...|.|.:..|:.... |..|:...|:|:||.|..:......|..:|.||:||:.|.:.|
Human   143 VGISLFATSFLTLCIPLATDF-GIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIA 206

  Fly   180 YSGNQFGTILMLATSGVIAASPIGWPSIFYISGGIGCVWSVVYFFFGAGSPQECKSISAEEKKLI 244
            .||...|....:...|.|:.: :|||.:|||.||:|||..:::|......|.....||..||:.|
Human   207 LSGMLLGCFTAILIGGFISET-LGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYI 270

  Fly   245 EMSQADEVSGGQEQPKEQLPTPWLSFFTS-PAFLVLIVSHSVHNWGFWTLLTEIPSYMKNILGKD 308
            ..|...:|...::      |.|..:...| |.:.:.:...| |.|...|::..||:|:.::...:
Human   271 ISSLKQQVGSSKQ------PLPIKAMLRSLPIWSICLGCFS-HQWLVSTMVVYIPTYISSVYHVN 328

  Fly   309 IKSNALLSSLPYVCMFAMSFVFSSISAQLNNRNCISRSTSRKLFNSIGLWIPMVTLVGLGYVNPD 373
            |:.|.|||:||::..:.:..|...::..|..:. ....|.||:...:|.......:|.|.|:|..
Human   329 IRDNGLLSALPFIVAWVIGMVGGYLADFLLTKK-FRLITVRKIATILGSLPSSALIVSLPYLNSG 392

  Fly   374 QSELAVVLLCFTVGMNGATYLGFNTNHIDLSPNFAGILMGITNGVANIMSIIAPLIVGFIVTNEH 438
            .. .|..||..:.|::.....|...|.:|::|.::..|||.:.|.::|..:|.|.:.||:::  .
Human   393 YI-TATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLS--Q 454

  Fly   439 DPE-QWRIVFFIAAGFYLVGNTLYVIFGKANVQPWNDPPAKPRR 481
            ||| .||.|||:.....|:|...|:|||:|:||.|    ||.|:
Human   455 DPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEW----AKERK 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15096	NP_611376.1	2A0114euk	36..480	CDD:129972	132/471 (28%)
CG15096	NP_611376.1	MFS	40..464	CDD:119392	122/451 (27%)
SLC17A3	NP_001091956.1	2A0114euk	23..497	CDD:129972	136/489 (28%)
SLC17A3	NP_001091956.1	MFS	98..481	CDD:119392	112/395 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750