DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15096 and SLC17A4

DIOPT Version :9

Sequence 1:	NP_611376.1	Gene:	CG15096 / 37170	FlyBaseID:	FBgn0034394	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_005486.1	Gene:	SLC17A4 / 10050	HGNCID:	10932	Length:	497	Species:	Homo sapiens

Alignment Length:	486	Identity:	147/486 - (30%)
Similarity:	243/486 - (50%)	Gaps:	48/486 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NSNKEDEAVGKHSGLGVRHFQVLLLFFALTVAYGCRVNLSVAVVAMT---------DAASVNP-- 72
            |.|...|...:.....|||...|:|.......|..::|||:|:.||.         :|::..|
Human    19 NLNVAQEECSRKGFCSVRHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPST 83

  Fly    73 -----------DF----PEYNWSEKTKSLLLSSFFWGYVITQVPAGQLARKYGGKVMILSGLAIC 122
                       :|    |.|:||.:.:.::|||..:|..:..:|:|.:|..:|.|.::.:||.|.
Human    84 DSQGYWNETLKEFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFIS 148

  Fly   123 SILNILTPICAKIGGWQLVCALRVVEGLCQGVVFPSTHTILSQWAPPKERATLGTCAYSGNQFGT 187
            |.|.:..|:.|. .|..|:..||:|:|:.|.:|....::|..:||||.||:.|.|.|.||:..|:
Human   149 SFLTLFIPLAAN-AGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGS 212

  Fly   188 ILMLATSGVIAASPIGWPSIFYISGGIGCVWSVVYFFFGAGSPQECKSISAEEKKLIEMSQA-DE 251
            .::|...|::..: ||||.:|||.|||||....::|......|.....|||.||:.|..|.| .:
Human   213 FIVLLAGGLLCQT-IGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQD 276

  Fly   252 VSGGQEQP----KEQLPTPWLSFFTSPAFLVLIVSHSVHNWGFWTLLTEIPSYMKNILGKDIKSN 312
            .|.|...|    .:.||. |          .::||:....|.|:|::...|:|:.::|..:::.:
Human   277 CSPGWSLPIRAMIKSLPL-W----------AILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDS 330

  Fly   313 ALLSSLPYVCMFAMSFVFSSISAQ-LNNRNCISRSTSRKLFNSIGLWIPMVTLVGLGYVNPDQSE 376
            .:||:||:| :..:..:...:.|. |.:|..:...|.||||.:||:..|.|.||.|.:|....|
Human   331 GILSALPFV-VGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHS- 393

  Fly   377 LAVVLLCFTVGMNGATYLGFNTNHIDLSPNFAGILMGITNGVANIMSIIAPLIVGFIVTNEHDPE 441
            :.:..|..:..::.....|...|.:|::|.:.|.|.|:....|:|...|:|...||.::.:.: .
Human   394 MTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSE-F 457

  Fly   442 QWRIVFFIAAGFYLVGNTLYVIFGKANVQPW 472
            .||.||.::|...:.|...|:|||:|:||.|
Human   458 GWRNVFLLSAAVNISGLVFYLIFGRADVQDW 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15096	NP_611376.1	2A0114euk	36..480	CDD:129972	143/469 (30%)
CG15096	NP_611376.1	MFS	40..464	CDD:119392	134/455 (29%)
SLC17A4	NP_005486.1	UhpC	30..491	CDD:332119	144/475 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740