DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JAK2 and hop

DIOPT Version :9

Sequence 1:	NP_001309123.1	Gene:	JAK2 / 3717	HGNCID:	6192	Length:	1132	Species:	Homo sapiens
Sequence 2:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster

Alignment Length:	1283	Identity:	314/1283 - (24%)
Similarity:	525/1283 - (40%)	Gaps:	301/1283 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     4 ACLTMTEM-EGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEY----- 62
            |.||.:.: .|||:.||:.|             |..::|:             .|.:||:
  Fly    25 ASLTNSSLRSGTSSQSIHTN-------------DGTIRVF-------------NFTTGEFERFHP 63

Human    63 --VAEEICIAASKACGITPVYHNMFALMS-ETERIWYPPNHVFHID-------ESTRHNVLY--R 115
              :.||||....:..||.|:...::.:.. .|.|   .|:.:..:|       |.....::|  |
  Fly    64 NMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSR---RPSPLVRLDLTWCLPGERLNCQLVYCFR 125

Human   116 IRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG 180
            :||..|               ...::..|:|.....:|:.|.|:|.....|......|.:::..|
  Fly   126 MRFRVP---------------ELDSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTG 175

Human   181 MAVLDMMRIAKENDQTPLAIYNSIS--YKTFLPKCI-RAKIQDYHILTRKRIRYRFRRFIQQFSQ 242
            :||:||:...:|..:...|: .||.  ||.:||..: ||    :......:||..||       .
  Fly   176 LAVMDMLIDDQEQSEDQQAM-RSIEKLYKLYLPPSLWRA----HSFFVGSKIREVFR-------S 228

Human   243 CKA---TARNLKLKYLINLETLQSAFYTEKF---------EVKEPGSGPSGEEI----------- 284
            .||   :...||..|:..:..|...:.||:|         |....||||.|..:
  Fly   229 LKANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSG 293

Human   285 ----FATIIITGNGGIQWSRGKHKESETLTEQDLQLYCD-FP-NIIDVSIKQANQEGSNESRVVT 343
                .:|:....|.......|| |.....|...:.:|.. || :.::..:|.|........:.:.
  Fly   294 STNTLSTLTTNTNSVALGGSGK-KAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWIL 357

Human   344 IHKQDG--------------------KNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVA 388
            :...:|                    |..|::..:.:|..||:|.:..|.||::.....||....
  Fly   358 VGAVEGIFMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYR 422

Human   389 PPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVE-RENVIEYKHC 452
            .|::.|....:|||||...:::.||.:.|::.|.|::|...:::|.|::....: .....:.:.|
  Fly   423 TPSLEELSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERC 487

Human   453 ------LITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLV 511
                  ::.|:...:.:.:..:...:||.::.:..|.::.....|        |....||..||:
  Fly   488 KTETFRIVRKDSQWKLSYNNGEHVLNSLHEVAHIIQADSPDRYRI--------PASKYDKPPLLL 544

Human   512 FRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREV--------- 567
                          |..|.::      |.:..||..:|:..|....:|| ..|.::
  Fly   545 --------------LLLPKNL------KAKKTDLQLSEAELQRRNPQIF-NPRTDLQWYPDSISL 588

Human   568 ----------GDYGQ---LHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCG 619
                      ||:.|   :.:..|.:|:| |:..|:.| ||..|...|.:.....:..||:.: .
  Fly   589 SDDGMMFTMRGDWIQQSPVKDVSVTMKML-KSDGNFME-FFRLAQTWSLIQSPQFLKLYGLTL-A 650

Human   620 DENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIRE 684
            |...:|.|:.::|.|:.:|....| :.:...|::...|...||:||:|.:||..:...|:.:.:.
  Fly   651 DPYTMVMEYSRYGPLNKFLHSMPN-VTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKY 714

Human   685 EDRKTGNPPFI---KLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLA-TDK----WSFGT 741
            :...     ::   |:||||     .|:...:...||:|   ::..:||..| ||:    |:|.|
  Fly   715 DPNS-----YVLDAKISDPG-----YPRPYRESDSPWIP---VKYYRNLQAAKTDQFAQLWAFAT 766

Human   742 TLWEICSGGDKPLSALDSQRKLQFYE---------DRHQLPAPKWAELANLINNCMDYEPD---F 794
            |::||.|...:.||.|..::.|:...         |:...|||       :....||...|   .
  Fly   767 TIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAP-------IFETIMDGWSDDETK 824

Human   795 RPSFRAIIRDLNSL---FTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFL---- 852
            |.|...|...||::   ..|:|        :|...|...|..      |.|..:...:.||
  Fly   825 RFSHHDIFSRLNTIKAEILPNY--------MPPPEIATNGTG------DETVIDRSDIPFLPFPR 875

Human   853 --------------------QQLGKGNFGSVEMCRYD-PLQDNTGEVVAVKKLQHSTEEHLRDFE 896
                                ..:|:|::|:|.....: ..:|...|.||:|.|  :|.:...||.
  Fly   876 SNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFH 938

Human   897 REIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQIC 961
            |||.|:::|.|.||||:|   |.|.:.:. :|||||..||...||:.....:::.:|:.:...|.
  Fly   939 REIGIMRTLSHPNIVKFK---YWAEKSHC-IIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIA 999

Human   962 KGMEYLGTKRYIHRDLATRNILVENE---NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 1023
            .||:||.....||||||.|||||::.   :.|||.||||.:....| .||..|...:.||.||:|
  Fly  1000 NGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSD-GYYYAKSKRDIPIRWYSP 1063

Human  1024 ESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRL 1088
            |:::..:||..|||||:||.|:|:|:..|:....|.:..:.            ..:..|::..||
  Fly  1064 EAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQE------------DFLNRLQSGERL 1116

Human  1089 PRPDGCPDEIYMIMTECWNNNVNQRPSF--------RDLALRVDQIRD 1128
            .||..|||.||.:|..||:.....||||        |::|.:|....|
  Fly  1117 NRPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVTHPTD 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAK2	NP_001309123.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239		58/255 (23%)
		B41	38..270	CDD:214604	56/254 (22%)
		FERM_C_JAK2	266..386	CDD:270141	32/165 (19%)
		SH2_Jak2	386..482	CDD:198242	19/102 (19%)
		PTK_Jak2_rpt1	545..806	CDD:270663	73/302 (24%)
		Pkinase_Tyr	545..805	CDD:285015	73/301 (24%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	105/318 (33%)
		TyrKc	849..1119	CDD:197581	103/305 (34%)
hop	NP_511119.2	B41	39..259	CDD:214604	60/275 (22%)
		SH2_Jak_family	420..516	CDD:198177	18/95 (19%)
		PTK_Jak_rpt1	584..836	CDD:270633	67/275 (24%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	101/287 (35%)
		TyrKc	894..1151	CDD:197581	100/275 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3279
Isobase	1	0.950	-	0	Normalized mean entropy	S4806
OMA	1	1.010	-	-		QHG47769
OrthoDB	1	1.010	-	-		D38412at33208
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		otm40514
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.930