Protein Alignment JAK2 and jak2b

DIOPT Version :10

• Sequence 1: NP_004963.1
• Gene: JAK2 / 3717
• HGNCID: 6192
• Length: 1132
• Species: Homo sapiens
• Sequence 2: NP_571162.1
• Gene: jak2b / 30298
• ZFINID: ZDB-GENE-980526-123
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1124
• Identity: 775/1124 - (68%)
• Similarity: 944/1124 - (83%)
• Gaps: 15/1124 - (1%)

Human    10 EMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADY--LTFPSGEYVAEEICIAAS 72
            :||.......|||||:.......|| ..||:::|||| .:|:||.  :.:|.|||:.|::.|.|:
Zfish     2 DMETAVCEPHYQNGDVHHEDPCPKQ-PTVLKIHLYHS-SRSDADSSPICYPPGEYITEQLIIHAA 64

Human    73 KACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGIS 137
            |..|::|||.::|.|..|.|.:|..||||.|:||:...::|:|:|:|||.||..|::||||:|::
Zfish    65 KESGVSPVYCSLFGLYKEDEAVWLSPNHVLHLDETANESLLFRMRYYFPGWYSCGTSRAYRYGVT 129

Human   138 RGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN 202
            :|:::|:|||:||||||||||.|||:||:|:..:||.||||||||||||||.|||.|.:||.|||
Zfish   130 KGSDSPVLDDYVMSYLFAQWRSDFVNGWVKLSGSHENQEECLGMAVLDMMRTAKEKDCSPLDIYN 194

Human   203 SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYT 267
            .||||:||||.:|.:|||||.:||||||||||:.:||.|||:.|||:|||||||:||:|.:.|||
Zfish   195 DISYKSFLPKDMRERIQDYHFVTRKRIRYRFRKVVQQLSQCRVTARDLKLKYLISLESLDNGFYT 259

Human   268 EKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQAN 332
            |:|:|||    ||.|::  ||:::.:.||||...:||  :|.:|..||.||||..::|:||:||:
Zfish   260 ERFQVKE----PSTEQV--TIVVSADRGIQWCHERHK--DTQSEDLLQTYCDFAEVVDISIRQAS 316

Human   333 QEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQ 397
            ::|:|.:|:|:|.:|||..||:..|:..:|||||||||||||||.||||||||:||||.:||.|:
Zfish   317 KDGTNMNRIVSIDRQDGTPLELVFSTSMQALSFVSLIDGYYRLTTDAHHYLCKDVAPPYLLEAIE 381

Human   398 SNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY 462
            |.||||||||||||||:|:|||.||:||||||||:||||||.|......:||||||||::|:..|
Zfish   382 SYCHGPISMDFAISKLRKSGNQKGLFVLRCSPKDYNKYFLTLAFGGYGNVEYKHCLITRSESGNY 446

Human   463 NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQ 527
            |||||||:|.||:|||.|||.|||:||.|:|||:|||.|:||:||:|||.|::...:||.|.:||
Zfish   447 NLSGTKKSFRSLQDLLKCYQKETVKSDGIVFQFSKCCSPRPKEKSSLLVCRSHRGLEVPLSSSLQ 511

Human   528 RPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSE 592
            | .:::|||||||:.|||...||.|||||||||||:|:|.||||:.|:|||::||||||||||||
Zfish   512 R-HNISQMVFHKIKKEDLELGESQGQGTFTKIFKGIRKEQGDYGETHKTEVIVKVLDKAHRNYSE 575

Human   593 SFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN--CINILWKLEVAK 655
            ||||||||||:|:||||||.||:||||||||:|||:||||||||||||||:  .:||||||||||
Zfish   576 SFFEAASMMSQLTHKHLVLTYGICVCGDENIMVQEYVKFGSLDTYLKKNKSSVSVNILWKLEVAK 640

Human   656 QLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP 720
            ||||||.:|||.:|.|||||||||||||||||..||.||||||||||||||||::||.|||||||
Zfish   641 QLAWAMLYLEEKSLAHGNVCAKNILLIREEDRALGNTPFIKLSDPGISITVLPREILVERIPWVP 705

Human   721 PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLIN 785
            ||||.:||||:|||||||||||||||||||::||:.:|:.:|..|||:.||||||||.|||||||
Zfish   706 PECILDPKNLSLATDKWSFGTTLWEICSGGEQPLANMDNSKKHLFYENHHQLPAPKWTELANLIN 770

Human   786 NCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLK 850
            :||||||.|||||:||||||||||.||||::.|:|::|:....::..:|.|::.:|.|||||||.
Zfish   771 SCMDYEPTFRPSFKAIIRDLNSLFCPDYEIVKESDIMPSRAAASIFNTGTFKNNEPVQFEERHLI 835

Human   851 FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKG 915
            ||||||||||||||||||||||||||||||||||||||.||:|||||||||||||||:|||||||
Zfish   836 FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTTEHIRDFEREIEILKSLQHENIVKYKG 900

Human   916 VCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATR 980
            |||.||||||:|:|||||||||||||.|:::||||.||:.|.||||||||||.||||||||||||
Zfish   901 VCYGAGRRNLRLVMEYLPYGSLRDYLNKNRDRIDHQKLVHYASQICKGMEYLATKRYIHRDLATR 965

Human   981 NILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLY 1045
            |||||:|.||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Zfish   966 NILVESECRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWHAPESLTESKFSVASDVWSFGVVLY 1030

Human  1046 ELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNV 1110
            |||||.:|..|||..|:.|:|.|||||.||:|||||||...|||:|.|||.|::.||.|||:|:.
Zfish  1031 ELFTYSDKLCSPPTVFLSMVGGDKQGQTIVYHLIELLKRGNRLPQPMGCPTEMFEIMQECWDNDP 1095

Human  1111 NQRPSFRDLALRVDQIRDN 1129
            :.||:|::||||||.|||:
Zfish  1096 SLRPNFKELALRVDLIRDS 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JAK2	NP_004963.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239		126/230 (55%)
		FERM_F1	39..134	CDD:465733	44/96 (46%)
		FERM_F2	143..261	CDD:436450	86/117 (74%)
		FERM_C_JAK2	266..386	CDD:270141	64/119 (54%)
		SH2_Jak2	386..482	CDD:198242	67/95 (71%)
		PTK_Jak2_rpt1	545..806	CDD:270663	209/262 (80%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	232/282 (82%)
jak2b	NP_571162.1	FERM_F1	30..126	CDD:465733	44/96 (46%)
		FERM_F2	134..253	CDD:436450	86/118 (73%)
		FERM_C_JAK2	258..370	CDD:270141	64/119 (54%)
		SH2_Jak2	370..466	CDD:198242	67/95 (71%)
		Protein Kinases, catalytic domain	528..791	CDD:473864	209/262 (80%)
		Protein Kinases, catalytic domain	829..1112	CDD:473864	232/282 (82%)