DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAK2 and fin1

DIOPT Version :9

Sequence 1:	NP_001309123.1	Gene:	JAK2 / 3717	HGNCID:	6192	Length:	1132	Species:	Homo sapiens
Sequence 2:	NP_593305.1	Gene:	fin1 / 2542237	PomBaseID:	SPAC19E9.02	Length:	722	Species:	Schizosaccharomyces pombe

Alignment Length:	299	Identity:	77/299 - (25%)
Similarity:	144/299 - (48%)	Gaps:	65/299 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   850 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ--HSTEEHLRDFEREIEILKSLQHDNIVK 912
            |.|:.:|.|:||.:  .:...|:|  |.::|.|::.  :.|.:..:....|:.||::|:|.|||:
pombe     5 KILECIGHGSFGRI--YKVQRLKD--GALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNIVQ 65

Human   913 YKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKE---RIDHIKLLQYTSQICKGM---------- 964
            |.|...:...:.:.|.|||..:|.|.:.:|::||   |....::|::.:|:...:
pombe    66 YCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENAP 130

Human   965 --------EYLGTKR-YIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYK--VKEPGESPI 1018
                    |....|: .:|||:...||.::..|.||:|||||:|:|...:.:.:  |..|
pombe   131 ACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVFTQSYVGTP----- 190

Human  1019 FWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK 1083
            ::.:||.:..|.:|..||||:.|.|::|:.               |:.:..:|:    ..:||.:
pombe   191 YYMSPEIIRSSPYSAKSDVWALGCVIFEIC---------------MLTHPFEGR----SYLELQR 236

Human  1084 N--NGRLPRPDGC-----PDEIYMIMTECWNNNVNQRPS 1115
            |  .|.|    .|     .|::::::..|...|.:.||:
pombe   237 NICQGNL----SCWDHHYSDDVFLLIRHCLEVNSDLRPT 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAK2	NP_001309123.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		B41	38..270	CDD:214604
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663
		Pkinase_Tyr	545..805	CDD:285015
		PTKc_Jak2_rpt2	844..1127	CDD:271107	77/299 (26%)
		TyrKc	849..1119	CDD:197581	77/299 (26%)
fin1	NP_593305.1	STKc_Nek2	3..281	CDD:270857	77/299 (26%)
fin1	NP_593305.1	S_TKc	4..281	CDD:214567	77/299 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910