| Sequence 1: | NP_001309123.1 | Gene: | JAK2 / 3717 | HGNCID: | 6192 | Length: | 1132 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_113702.1 | Gene: | Jak2 / 24514 | RGDID: | 2939 | Length: | 1132 | Species: | Rattus norvegicus |
| Alignment Length: | 1131 | Identity: | 1071/1131 - (94%) |
|---|---|---|---|
| Similarity: | 1102/1131 - (97%) | Gaps: | 0/1131 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAE 65
Human 66 EICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNR 130
Human 131 AYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQ 195
Human 196 TPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLET 260
Human 261 LQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIID 325
Human 326 VSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPP 390
Human 391 AVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLIT 455
Human 456 KNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDV 520
Human 521 PTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK 585
Human 586 AHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK 650
Human 651 LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 715
Human 716 IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL 780
Human 781 ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFE 845
Human 846 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI 910
Human 911 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHR 975
Human 976 DLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSF 1040
Human 1041 GVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC 1105
Human 1106 WNNNVNQRPSFRDLALRVDQIRDNMA 1131 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| JAK2 | NP_001309123.1 | Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 | 1..239 | 216/237 (91%) | |
| B41 | 38..270 | CDD:214604 | 217/231 (94%) | ||
| FERM_C_JAK2 | 266..386 | CDD:270141 | 109/119 (92%) | ||
| SH2_Jak2 | 386..482 | CDD:198242 | 92/95 (97%) | ||
| PTK_Jak2_rpt1 | 545..806 | CDD:270663 | 248/260 (95%) | ||
| Pkinase_Tyr | 545..805 | CDD:285015 | 247/259 (95%) | ||
| PTKc_Jak2_rpt2 | 844..1127 | CDD:271107 | 276/282 (98%) | ||
| TyrKc | 849..1119 | CDD:197581 | 264/269 (98%) | ||
| Jak2 | NP_113702.1 | Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 | 1..239 | 216/237 (91%) | |
| FERM_F1 | 39..134 | CDD:408179 | 85/94 (90%) | ||
| FERM_F2 | 143..261 | CDD:408177 | 114/117 (97%) | ||
| FERM_C_JAK2 | 266..386 | CDD:270141 | 109/119 (92%) | ||
| SH2_Jak2 | 386..482 | CDD:198242 | 92/95 (97%) | ||
| PTK_Jak2_rpt1 | 545..806 | CDD:270663 | 248/260 (95%) | ||
| PTKc_Jak2_rpt2 | 844..1127 | CDD:271107 | 276/282 (98%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83686188 | |
| Domainoid | 1 | 1.000 | 552 | 1.000 | Domainoid score | I5822 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H21033 | |
| Inparanoid | 1 | 1.050 | 2214 | 1.000 | Inparanoid score | I1115 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG47769 | |
| OrthoDB | 1 | 1.010 | - | - | D13590at9347 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001105 | |
| OrthoInspector | 1 | 1.000 | - | - | oto141014 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100013 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR45807 |
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 1 | 1.000 | - | - | X669 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 16.410 | |||||