DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JAK2 and mlk-1

DIOPT Version :9

Sequence 1:	NP_001309123.1	Gene:	JAK2 / 3717	HGNCID:	6192	Length:	1132	Species:	Homo sapiens
Sequence 2:	NP_001300151.1	Gene:	mlk-1 / 178895	WormBaseID:	WBGene00003374	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	119/462 - (25%)
Similarity:	174/462 - (37%)	Gaps:	138/462 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   770 HQLPAPKW-----AELANLINNCMDYEPDFR------------PSFRAIIRDLNSLFTPDYELLT 817
            |..|.|:.     .|.....:...|..|:.|            |..||     :..|...||...
Worm    23 HLAPTPEHHRSVSYEDTTTASTSTDSVPEVRIRSESSQVSRESPPIRA-----SKAFVASYEYEA 82

Human   818 ENDMLPNMRIGAL-------------------GFSGAFED---RDPTQFEERHLKFLQ------- 853
            :.|...|:.:||:                   |..|.|..   |:.| :::..::|.|
Worm    83 QKDDELNLPLGAIITLVTVETNEDGWYRGELNGKVGLFPSNYAREVT-YKDNLVEFKQDEIMLPV 146

Human   854 --------QLGKGNFGSV---EMCRYDPLQD-NTGEVV------AVKKLQH----------STEE 890
                    |:|.|...:|   ::.....||: ..||.|      |:|:...          ||:|
Worm   147 AVRTLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDE 211

Human   891 HLRDFEREIEILKSLQHDNIVKYKGVC----YSAGRRNLKLIMEYLPYGSLRDYLQ--KHKERID 949
            .|...:||..::..|.|:|||:..|:|    |      ..|::|.....|||:..:  .....|.
Worm   212 QLEQLKREANLVNGLSHNNIVRLLGICLEDPY------FGLLLELCEGSSLRNVCRNLNSDAAIP 270

Human   950 HIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE-------------------------NR 989
            ...|:.:.:|:.:|||||..:.|:||||...|:||:.|                         .:
Worm   271 LGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQ 335

Human   990 VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKS 1054
            :||.|||:|:.:..|...:..    .....|.|||:..|..:|.||||||:||||:||.|..|..
Worm   336 LKITDFGVTRKMTADANRFST----AGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPY 396

Human  1055 KSP-PAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRD 1118
            :.. ||.....|.|..|...|                .|.|||....:|.:|||...|.||.|..
Worm   397 QGHIPATIAFQIANKGQNLSI----------------GDSCPDRWKKLMQDCWNLEPNFRPKFST 445

Human  1119 LALRVDQ 1125
            ||:...|
Worm   446 LAISFKQ 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAK2	NP_001309123.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		B41	38..270	CDD:214604
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663	10/52 (19%)
		Pkinase_Tyr	545..805	CDD:285015	10/51 (20%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	97/349 (28%)
		TyrKc	849..1119	CDD:197581	94/336 (28%)
mlk-1	NP_001300151.1	SH3	75..124	CDD:302595	9/48 (19%)
		STYKc	153..450	CDD:214568	94/322 (29%)
		PKc_like	156..446	CDD:304357	91/315 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810