| Sequence 1: | NP_001309123.1 | Gene: | JAK2 / 3717 | HGNCID: | 6192 | Length: | 1132 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001090634.1 | Gene: | jak2 / 100036599 | XenbaseID: | XB-GENE-483712 | Length: | 1129 | Species: | Xenopus tropicalis |
| Alignment Length: | 1128 | Identity: | 882/1128 - (78%) |
|---|---|---|---|
| Similarity: | 1013/1128 - (89%) | Gaps: | 1/1128 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 3 MACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEI 67
Human 68 CIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAY 132
Human 133 RHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTP 197
Human 198 LAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ 262
Human 263 SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVS 327
Human 328 IKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAV 392
Human 393 LENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKN 457
Human 458 ENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPT 522
Human 523 SPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAH 587
Human 588 RNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE 652
Human 653 VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP 717
Human 718 WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELAN 782
Human 783 LINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEER 847
Human 848 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVK 912
Human 913 YKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL 977
Human 978 ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGV 1042
Human 1043 VLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWN 1107
Human 1108 NNVNQRPSFRDLALRVDQIRDNM 1130 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| JAK2 | NP_001309123.1 | Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 | 1..239 | 154/235 (66%) | |
| B41 | 38..270 | CDD:214604 | 168/231 (73%) | ||
| FERM_C_JAK2 | 266..386 | CDD:270141 | 81/119 (68%) | ||
| SH2_Jak2 | 386..482 | CDD:198242 | 71/95 (75%) | ||
| PTK_Jak2_rpt1 | 545..806 | CDD:270663 | 219/260 (84%) | ||
| Pkinase_Tyr | 545..805 | CDD:285015 | 218/259 (84%) | ||
| PTKc_Jak2_rpt2 | 844..1127 | CDD:271107 | 253/282 (90%) | ||
| TyrKc | 849..1119 | CDD:197581 | 246/269 (91%) | ||
| jak2 | NP_001090634.1 | FERM_F1 | 37..132 | CDD:375805 | 58/94 (62%) |
| FERM_F2 | 140..259 | CDD:375803 | 97/118 (82%) | ||
| FERM_C_JAK2 | 264..384 | CDD:270141 | 81/119 (68%) | ||
| SH2_Jak2 | 384..480 | CDD:198242 | 71/95 (75%) | ||
| PTK_Jak2_rpt1 | 543..804 | CDD:270663 | 219/260 (84%) | ||
| PTKc_Jak2_rpt2 | 841..1124 | CDD:271107 | 253/282 (90%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 518 | 1.000 | Domainoid score | I3453 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H21033 | |
| Inparanoid | 1 | 1.050 | 1862 | 1.000 | Inparanoid score | I828 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG47769 | |
| OrthoDB | 1 | 1.010 | - | - | D38412at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001105 | |
| OrthoInspector | 1 | 1.000 | - | - | oto157198 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR45807 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X669 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 12 | 12.080 | |||||