DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS15 and slc17a5

DIOPT Version :9

Sequence 1:	NP_611375.2	Gene:	MFS15 / 37168	FlyBaseID:	FBgn0034392	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001070195.1	Gene:	slc17a5 / 767760	ZFINID:	ZDB-GENE-060929-1158	Length:	488	Species:	Danio rerio

Alignment Length:	488	Identity:	188/488 - (38%)
Similarity:	272/488 - (55%)	Gaps:	64/488 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PCCNHNGYQQIGNTGPRFGVRHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNAS---------- 61
            |.|..:          |:|:..|.|    :|..|||:||||||||:|.|. :|:|
Zfish    30 PACGSS----------RYGLAFLSC----YGFFVAYALRVNLSVAMVDML-KNSSKANTSSSICP 79

  Fly    62 --NPDFPE-------FDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLA 117
              |...|:       :|||..|:.::|.|||:||::||||||||:..||||::|..|:|......
Zfish    80 PHNIPVPKHNHTAMVYDWNSETQGWILGSFFYGYIITQIPGGYLARKYGAKWLLGLGILCTVIFT 144

  Fly   118 LLTPFCA-VNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVM 181
            ||||..| :..|:.:.|  |.::|:.:||.:|:.|...:.|||..||.||:..:|:|:|.||||.
Zfish   145 LLTPLAADLGAGYLIAV--RVLEGIGEGVTYPAMHAMWASWAPPLERSRLLTISYTGAQLGTVVA 207

  Fly   182 LSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFIESSGQARRPSD 246
            |.:||.|. ..|.|...|||.|.||::|.|:|:...|::|:.|..||..|:.:|.||
Zfish   208 LPLSGQIC-FYLDWTYVFYIFGAVGLLWFFLWICFVSNSPSSHKRITEAEKTYIMSS-------- 263

  Fly   247 AGREEQPRPPT----PWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPL 307
               .:....||    ||..||.|:|...:|:||.:.||.|:||||.:||:|.:|||..|:.||.|
Zfish   264 ---LKNELSPTQDYIPWTSIFKSMPLWAIVVAHFSYNWTFYTLLTLLPTYMNDVLGFSIQQNGML 325

  Fly   308 SALPYFAMILLTCVFIWLSDTLKQR---GTVIPLGFSRKFFNTLGMWLPMLALIGLGYITEGEAN 369
            |||||....||..:...|:|.|::|   .|||    .||.|..:||..|.:.|:..||.   ..|
Zfish   326 SALPYLGCWLLALLGGQLADLLRERFLFRTVI----VRKAFTVVGMAGPAVFLVAAGYT---GCN 383

  Fly   370 VRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIVWDETN 434
            ..||:..||.:.:....:..||::||:|::|:|||.|:||||..|....::.|:|...:....|.
Zfish   384 YILAVAFLTISSSLGGISASGFNINHLDIAPSYAGILLGITNSFATIPGMVGPVIARSLTKSNTI 448

  Fly   435 PAQWRIVFFFTAFVYFIGNLLFMLFGRTRVQPW 467
            | :|:|||:.:|.:...|.:.|.:||:..||||
Zfish   449 P-EWQIVFYISAAINIFGAVFFTIFGKGTVQPW 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS15	NP_611375.2	2A0114euk	18..469	CDD:129972	186/477 (39%)
MFS15	NP_611375.2	MFS	31..459	CDD:119392	177/454 (39%)
slc17a5	NP_001070195.1	2A0114euk	27..488	CDD:129972	188/488 (39%)
slc17a5	NP_001070195.1	MFS	92..472	CDD:119392	158/401 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582555
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2916
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.880