DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS15 and slc17a6a

DIOPT Version :9

Sequence 1:	NP_611375.2	Gene:	MFS15 / 37168	FlyBaseID:	FBgn0034392	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001009982.1	Gene:	slc17a6a / 494492	ZFINID:	ZDB-GENE-050105-4	Length:	587	Species:	Danio rerio

Alignment Length:	484	Identity:	163/484 - (33%)
Similarity:	257/484 - (53%)	Gaps:	29/484 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGV--RHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNASN-------PDFPEFDWNESTKSYLL 79
            ||:  |::..|:...|..:::.:|.||.||||.|.:.:..:       ....:|:|:..|...:.
Zfish    65 FGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHKGGKIIIKGKAKFNWDPETVGMIH 129

  Fly    80 SSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCA-VNGGWTVVVVLRAVQGLCQ 143
            .||||||.||||||||:|:...|..:....:|:.|.|.:..|..| |:.|  .|:.:|.:|||.:
Zfish   130 GSFFWGYTVTQIPGGYISSRLAANRVFGAAILLTSTLNMFIPSAARVHYG--CVMFVRILQGLVE 192

  Fly   144 GVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIV 208
            ||.:|:.|...|||||..||.||...::.||..|.||.:.::|.:...| ||.|.|||.|..|||
Zfish   193 GVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGILVQYS-GWSSVFYIYGSFGIV 256

  Fly   209 WSFVWLYLCSSTPAQHPTITPNERRFIESS-GQARRPSDAGREEQPRPPTPWWRIFTSVPFLVLV 272
            |...|:.:...:||.|||||..||.:||.| |::.:...|    ..:..|||.:.|||:|...::
Zfish   257 WYMFWILVSYESPADHPTITDEERTYIEESIGESAKLLGA----MEKYKTPWRKFFTSMPVYAII 317

  Fly   273 LAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIP 337
            :|:...:|.|:.||...|.:.:.|.|.:|...|.:||||:..|.::..:...|:|.|:.: .::.
Zfish   318 VANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMVSALPHLVMTIIVPIGGQLADYLRSK-NILT 381

  Fly   338 LGFSRKFFNT--LGMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVNHIDLSP 400
            ....||..|.  .||...:|.::|..: ::|     :||..|..||..:.....||:|||:|::|
Zfish   382 TTTVRKIMNCGGFGMEATLLLVVGFSH-SKG-----VAISFLVLAVGFSGFAISGFNVNHLDIAP 440

  Fly   401 NYAGTLMGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFFFTAFVYFIGNLLFMLFGRTRVQ 465
            .||..||||:|.......::.|||||.:..::|. .:|:.||...:.|::.|.:.:.:|.....|
Zfish   441 RYASILMGISNGVGTLSGMVCPLIVGAMTKNKTR-EEWQNVFLIASLVHYGGVIFYGIFASGEKQ 504

  Fly   466 PWNSRPTTRTPSPGGGGERDEGTEDRGPL 494
            || :.|...:....|..:.||..|:.|.:
Zfish   505 PW-ADPEETSDEKCGFIDEDELAEETGDI 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS15	NP_611375.2	2A0114euk	18..469	CDD:129972	157/457 (34%)
MFS15	NP_611375.2	MFS	31..459	CDD:119392	150/438 (34%)
slc17a6a	NP_001009982.1	2A0114euk	70..512	CDD:129972	156/457 (34%)
slc17a6a	NP_001009982.1	MFS	75..499	CDD:119392	150/438 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12425
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830