DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS15 and dmGlut

DIOPT Version :9

Sequence 1:	NP_611375.2	Gene:	MFS15 / 37168	FlyBaseID:	FBgn0034392	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_620115.2	Gene:	dmGlut / 47253	FlyBaseID:	FBgn0010497	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	168/516 - (32%)
Similarity:	259/516 - (50%)	Gaps:	75/516 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PRFGV----------RHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNASNPDFPE--------- 67
            |::|:          |.:..|:.|..:..||::||.||.||..:..:..|..|..|
  Fly     5 PQWGISLSRYFVIPQRVILAIMGFLAILNAYTMRVCLSQAITVLVVKKNSTDDDSEAICEPDDID 69

  Fly    68 --------FDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCA 124
                    |:|:|..:..:||||:.||:||.||||.|:..:|.|:.|..|:|..:...:|||. |
  Fly    70 EGTSVGGDFEWSEELQGLILSSFYIGYIVTHIPGGLLAEKFGGKWTLGLGILSTAVFTMLTPL-A 133

  Fly   125 VNGG---WTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSG 186
            :|.|   |  ::|.|.:.||.:|..||:....|:.|.||.|||:|......|.|.||::...:||
  Fly   134 INKGDSDW--LIVTRVLMGLGEGTTFPALSVLLAAWVPANERGKLGALVLGGGQVGTIMGNLLSG 196

  Fly   187 YIASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRF-IESSGQARRPSDAGRE 250
             :...:.||...||..|.:|:||..::::||.|.|..||.|.|:||.: ::..|...|..|.
  Fly   197 -VFIDAYGWEFVFYFFGGLGVVWFAIFMFLCYSDPTSHPFIKPSEREYLVKEIGTISRNEDL--- 257

  Fly   251 EQPRPPTPWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAM 315
                |||||..|.|::|...||.|...::|||:.::|::|.:|.:||...||.||..|:|||..|
  Fly   258 ----PPTPWKAILTNLPMFALVAAQIGHDWGFYIMVTDLPKYMADVLQFSIKANGLYSSLPYVMM 318

  Fly   316 ILLTCVFIWLSDTLKQRGTVIPLGFSRKFFNTLGMWLPMLALIGLGYITEGEANVRLAIGLLTAA 380
            .:::....:::|.:.:|| |:....:||....|..:.|.:.::|..|  .|...| |.:.|.|..
  Fly   319 WIVSVGSGFVADWMIRRG-VLSTTNTRKVMTGLAAFGPAIFMVGASY--AGCDRV-LVVVLFTIC 379

  Fly   381 VATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFF-- 443
            :....|.|.|..::.:|:|||||||||.|||.......::.|.:|| ::....:..:||:||:
  Fly   380 MGLMGAYYAGMKLSPLDMSPNYAGTLMAITNGIGAITGVITPYLVG-VMTPNASLLEWRLVFWVA 443

  Fly   444 -----FTAFVYFIGNLLFMLFGRTRVQPWNSRPTTRTPSPGG----------GGERDEGTE 489
                 |||.:|.|       :....|||:|:.|.    .|..          |||:..|.|
  Fly   444 FGVLCFTAVIYCI-------WASGEVQPFNNAPI----QPRSVDFEAQERKVGGEKTSGLE 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS15	NP_611375.2	2A0114euk	18..469	CDD:129972	160/484 (33%)
MFS15	NP_611375.2	MFS	31..459	CDD:119392	154/455 (34%)
dmGlut	NP_620115.2	2A0114euk	25..463	CDD:129972	154/460 (33%)
dmGlut	NP_620115.2	MFS	77..458	CDD:119392	141/403 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451929
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	9	8.890